pCAG-CBE4max-SpG-P2A-EGFP (RTW4552) Citations (13)
Originally described in: Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants.Walton RT, Christie KA, Whittaker MN, Kleinstiver BP Science. 2020 Apr 17;368(6488):290-296. doi: 10.1126/science.aba8853. Epub 2020 Mar 26. PubMed Journal
Articles Citing pCAG-CBE4max-SpG-P2A-EGFP (RTW4552)
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Engineered Prime Editors with PAM flexibility.
Kweon J, Yoon JK, Jang AH, Shin HR, See JE, Jang G, Kim JI, Kim Y.
Mol Ther. 2021 Feb 23. pii: S1525-0016(21)00089-7. doi: 10.1016/j.ymthe.2021.02.022.
PubMed
Associated Plasmids |
| STAT1 gain-of-function heterozygous cell models reveal diverse interferon-signature gene transcriptional responses. Scott O, Lindsay K, Erwood S, Mollica A, Roifman CM, Cohn RD, Ivakine EA. NPJ Genom Med. 2021 May 14;6(1):34. doi: 10.1038/s41525-021-00196-7. PubMed |
| Disease modeling by efficient genome editing using a near PAM-less base editor in vivo. Rosello M, Serafini M, Mignani L, Finazzi D, Giovannangeli C, Mione MC, Concordet JP, Del Bene F. Nat Commun. 2022 Jun 15;13(1):3435. doi: 10.1038/s41467-022-31172-z. PubMed |
| Non-synonymous, synonymous, and non-coding nucleotide variants contribute to recurrently altered biological processes during retinoblastoma progression. Stachelek K, Harutyunyan N, Lee S, Beck A, Kim J, Xu L, Berry JL, Nagiel A, Reynolds CP, Murphree AL, Lee TC, Aparicio JG, Cobrinik D. Genes Chromosomes Cancer. 2023 May;62(5):275-289. doi: 10.1002/gcc.23120. Epub 2023 Jan 5. PubMed |
Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation.
Ma D, Yuan Q, Peng F, Paredes V, Zeng H, Osikpa EC, Yang Q, Peddi A, Patel A, Liu MS, Sun Z, Gao X.
J Am Chem Soc. 2023 Jan 25;145(3):1593-1606. doi: 10.1021/jacs.2c09129. Epub 2023 Jan 10.
PubMed
Associated Plasmids |
| Genetic knockdown of genes that are obscure, conserved and essential using CRISPR interference methods in the fission yeast S. pombe. Ishikawa K, Soejima S, Saitoh S. J Cell Sci. 2023 May 1;136(9):jcs261186. doi: 10.1242/jcs.261186. Epub 2023 May 10. PubMed |
| Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice. Zuo Y, Zhang C, Zhou Y, Li H, Xiao W, Herzog RW, Xu J, Zhang J, Chen YE, Han R. Cell Biosci. 2023 Jun 15;13(1):109. doi: 10.1186/s13578-023-01036-0. PubMed |
| Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells. Kim HS, Grimes SM, Chen T, Sathe A, Lau BT, Hwang GH, Bae S, Ji HP. Nat Biotechnol. 2023 Sep 11. doi: 10.1038/s41587-023-01949-8. PubMed |
| Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death. Weis D, Lin LL, Wang HH, Li ZJ, Kusikova K, Ciznar P, Wolf HM, Leiss-Piller A, Wang Z, Wei X, Weis S, Skalicka K, Hrckova G, Danisovic L, Soltysova A, Yang TT, Feichtinger RG, Mayr JA, Qi L. J Clin Invest. 2024 Jan 16;134(2):e170882. doi: 10.1172/JCI170882. PubMed |
| Selective haematological cancer eradication with preserved haematopoiesis. Garaude S, Marone R, Lepore R, Devaux A, Beerlage A, Seyres D, Dell' Aglio A, Juskevicius D, Zuin J, Burgold T, Wang S, Katta V, Manquen G, Li Y, Larrue C, Camus A, Durzynska I, Wellinger LC, Kirby I, Van Berkel PH, Kunz C, Tamburini J, Bertoni F, Widmer CC, Tsai SQ, Simonetta F, Urlinger S, Jeker LT. Nature. 2024 Jun;630(8017):728-735. doi: 10.1038/s41586-024-07456-3. Epub 2024 May 22. PubMed |
| The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis. Wu X, Liu R, Zhang Z, Yang J, Liu X, Jiang L, Fang M, Wang S, Lai L, Song Y, Li Z. EMBO Mol Med. 2024 Sep;16(9):2002-2023. doi: 10.1038/s44321-024-00113-2. Epub 2024 Jul 30. PubMed |
| Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis. Zou Y, Guo S, Wen L, Lv D, Tu J, Liao Y, Chen W, Chen Z, Li H, Chen J, Shen J, Xie X. Cell Rep Med. 2024 Sep 17;5(9):101728. doi: 10.1016/j.xcrm.2024.101728. PubMed |
| Functional rescue of F508del-CFTR through revertant mutations introduced by CRISPR base editing. Carrozzo I, Maule G, Gentile C, Umbach A, Ciciani M, Guidone D, De Santis M, Petris G, Vicente Galietta LJ, Arosio D, Cereseto A. Mol Ther. 2025 Mar 5;33(3):970-985. doi: 10.1016/j.ymthe.2025.01.011. Epub 2025 Jan 10. PubMed |
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