pLVX-EF1alpha-SARS-CoV-2-orf3a-2xStrep-IRES-Puro Citations (13)
Originally described in: A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, Garcia-Sastre A, Shokat KM, Shoichet BK, Krogan NJ Nature. 2020 Jul;583(7816):459-468. doi: 10.1038/s41586-020-2286-9. Epub 2020 Apr 30. PubMed Journal
Articles Citing pLVX-EF1alpha-SARS-CoV-2-orf3a-2xStrep-IRES-Puro
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| Severe acute respiratory syndrome coronavirus 2 ORF3a induces the expression of ACE2 in oral and pulmonary epithelial cells and the food supplement Vita Deyun((R)) diminishes this effect. Aguilar-Lemarroy A, Lopez-Uribe A, Sanchez-Corona J, Jave-Suarez LF. Exp Ther Med. 2021 May;21(5):485. doi: 10.3892/etm.2021.9916. Epub 2021 Mar 16. PubMed |
| Effect of SARS-CoV-2 proteins on vascular permeability. Rauti R, Shahoha M, Leichtmann-Bardoogo Y, Nasser R, Paz E, Tamir R, Miller V, Babich T, Shaked K, Ehrlich A, Ioannidis K, Nahmias Y, Sharan R, Ashery U, Maoz BM. Elife. 2021 Oct 25;10. pii: 69314. doi: 10.7554/eLife.69314. PubMed |
| Detecting SARS-CoV-2 Orf3a and E ion channel activity in COVID-19 blood samples. Yu HG, Sizemore G, Smoot K, Perrotta P. J Clin Transl Sci. 2021 Sep 14;5(1):e196. doi: 10.1017/cts.2021.856. eCollection 2021. PubMed |
| SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export. Hall R, Guedan A, Yap MW, Young GR, Harvey R, Stoye JP, Bishop KN. PLoS Pathog. 2022 Aug 25;18(8):e1010349. doi: 10.1371/journal.ppat.1010349. eCollection 2022 Aug. PubMed |
| Cyclin D3 restricts SARS-CoV-2 envelope incorporation into virions and interferes with viral spread. Gupta RK, Mlcochova P. EMBO J. 2022 Nov 17;41(22):e111653. doi: 10.15252/embj.2022111653. Epub 2022 Oct 10. PubMed |
| SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D. Lee MJ, Leong MW, Rustagi A, Beck A, Zeng L, Holmes S, Qi LS, Blish CA. Cell Rep. 2022 Dec 27;41(13):111892. doi: 10.1016/j.celrep.2022.111892. Epub 2022 Dec 12. PubMed |
| SARS-CoV-2 ORF3a expression in brain disrupts the autophagy-lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis. Zhu H, Byrnes C, Lee YT, Tuymetova G, Duffy HBD, Bakir JY, Pettit SN, Angina J, Springer DA, Allende ML, Kono M, Proia RL. FASEB J. 2023 May;37(5):e22919. doi: 10.1096/fj.202300149R. PubMed |
| Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19. Wu X, Manske MK, Ruan GJ, Witter TL, Nowakowski KE, Abeykoon JP, Tang X, Yu Y, Gwin KA, Wu A, Taupin V, Bhardwaj V, Paludo J, Dasari S, Dong H, Ansell SM, Badley AD, Schellenberg MJ, Witzig TE. iScience. 2023 Jun 16;26(6):106929. doi: 10.1016/j.isci.2023.106929. Epub 2023 May 18. PubMed |
| Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53. Lee JD, Menasche BL, Mavrikaki M, Uyemura MM, Hong SM, Kozlova N, Wei J, Alfajaro MM, Filler RB, Muller A, Saxena T, Posey RR, Cheung P, Muranen T, Heng YJ, Paulo JA, Wilen CB, Slack FJ. Cell Rep. 2023 Dec 26;42(12):113478. doi: 10.1016/j.celrep.2023.113478. Epub 2023 Nov 21. PubMed |
| SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR. Laprise F, Arduini A, Duguay M, Pan Q, Liang C. Viruses. 2024 Jun 22;16(7):1008. doi: 10.3390/v16071008. PubMed |
| Subcellular localization of SARS-CoV-2 E and 3a proteins along the secretory pathway. Hinkle JJ, Trychta KA, Wires ES, Osborn RM, Leach JR, Faraz ZF, Svarcbahs R, Richie CT, Dewhurst S, Harvey BK. J Mol Histol. 2025 Mar 1;56(2):98. doi: 10.1007/s10735-025-10375-w. PubMed |
Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.
Broderick K, Moutaoufik MT, Saccon T, Malty R, Amin S, Phanse S, Joseph TP, Zilocchi M, Hosseinnia A, Istace Z, Hajikarimlou M, Abrar S, Fisher J, Brassard R, Perera R, Kumar A, Aoki H, Rahmatbakhsh M, Jessulat M, Kobasa D, Dehne F, Prasad B, Gagarinova A, Joanne Lemieux M, Cochrane A, Houry WA, Aly KA, Golshani A, Babu M.
Nat Commun. 2025 Jul 1;16(1):5784. doi: 10.1038/s41467-025-60949-1.
PubMed
Associated Plasmids |
| ORF3a is a key driver of maternal SARS-CoV-2 infection-associated placental dysfunction. Mysorekar I, Kumar D, McColl E, Karvas R, Jones B, Tran L, Diveley E, Jash S, Sharma S, Kelly J, Theunissen T. Res Sq [Preprint]. 2025 Jul 3:rs.3.rs-6857689. doi: 10.21203/rs.3.rs-6857689/v1. PubMed |
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