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WWP-Luc (p21/WAF1 promoter) Citations (35)

Originally described in: WAF1, a potential mediator of p53 tumor suppression.
el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B Cell. 1993 Nov 19. 75(4):817-25.
PubMed Journal

Articles Citing WWP-Luc (p21/WAF1 promoter)

p53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest. Zhang K, Wu J, Wu X, Wang X, Wang Y, Zhou N, Kuo ML, Liu X, Zhou B, Chang L, Ann D, Yen Y. Mol Cancer Ther. 2011 Feb;10(2):269-78. doi: 10.1158/1535-7163.MCT-10-0728. Epub 2011 Jan 7. PubMed
Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21. Huang Y, Tong S, Tai AW, Hussain M, Lok AS. Gastroenterology. 2011 Oct;141(4):1412-21, 1421.e1-5. doi: 10.1053/j.gastro.2011.06.048. Epub 2011 Jun 24. PubMed
Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway. Thakur BK, Chandra A, Dittrich T, Welte K, Chandra P. Biochem Biophys Res Commun. 2012 Jul 27;424(2):245-50. doi: 10.1016/j.bbrc.2012.06.084. Epub 2012 Jun 23. PubMed
The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs). Perez-Madrigal D, Finegan KG, Paramo B, Tournier C. Cell Signal. 2012 Dec;24(12):2360-8. doi: 10.1016/j.cellsig.2012.08.001. Epub 2012 Aug 15. PubMed
Identification of HEXIM1 as a positive regulator of p53. Lew QJ, Chia YL, Chu KL, Lam YT, Gurumurthy M, Xu S, Lam KP, Cheong N, Chao SH. J Biol Chem. 2012 Oct 19;287(43):36443-54. doi: 10.1074/jbc.M112.374157. Epub 2012 Sep 4. PubMed
p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Yang Y, Tarapore RS, Jarmel MH, Tetreault MP, Katz JP. Cell Cycle. 2012 Nov 1;11(21):4033-9. doi: 10.4161/cc.22265. Epub 2012 Sep 18. PubMed

Associated Plasmids

Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. Ene CI, Edwards L, Riddick G, Baysan M, Woolard K, Kotliarova S, Lai C, Belova G, Cam M, Walling J, Zhou M, Stevenson H, Kim HS, Killian K, Veenstra T, Bailey R, Song H, Zhang W, Fine HA. PLoS One. 2012;7(12):e51407. doi: 10.1371/journal.pone.0051407. Epub 2012 Dec 7. PubMed
A single mutant, A276S of p53, turns the switch to apoptosis. Reaz S, Mossalam M, Okal A, Lim CS. Mol Pharm. 2013 Apr 1;10(4):1350-9. doi: 10.1021/mp300598k. Epub 2013 Mar 1. PubMed
Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. Chang HL, Chen CY, Hsu YF, Kuo WS, Ou G, Chiu PT, Huang YH, Hsu MJ. Biochim Biophys Acta. 2013 Aug;1830(8):4053-64. doi: 10.1016/j.bbagen.2013.04.011. Epub 2013 Apr 12. PubMed
A chimeric p53 evades mutant p53 transdominant inhibition in cancer cells. Okal A, Mossalam M, Matissek KJ, Dixon AS, Moos PJ, Lim CS. Mol Pharm. 2013 Oct 7;10(10):3922-33. doi: 10.1021/mp400379c. Epub 2013 Sep 9. PubMed
Cloning, characterization and expression analysis of a caspase-8 like gene from the Hong Kong oyster, Crassostrea hongkongensis. Xiang Z, Qu F, Qi L, Zhang Y, Tong Y, Yu Z. Fish Shellfish Immunol. 2013 Dec;35(6):1797-803. doi: 10.1016/j.fsi.2013.08.026. Epub 2013 Sep 25. PubMed
c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver. Ferreira DM, Afonso MB, Rodrigues PM, Simao AL, Pereira DM, Borralho PM, Rodrigues CM, Castro RE. Mol Cell Biol. 2014 Mar;34(6):1100-20. doi: 10.1128/MCB.00420-13. Epub 2014 Jan 13. PubMed
Cloning and characterization of an apoptosis-related DNA fragmentation factor (DFF) from oyster, Crassostrea hongkongensis. Xiang Z, Qu F, Qi L, Ying T, Li J, Shu X, Yu Z. Fish Shellfish Immunol. 2014 May;38(1):119-26. doi: 10.1016/j.fsi.2014.03.006. Epub 2014 Mar 15. PubMed
TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, Zhang L. Oncotarget. 2014 Sep 30;5(18):8107-22. PubMed
ANKHD1 represses p21 (WAF1/CIP1) promoter and promotes multiple myeloma cell growth. Dhyani A, Machado-Neto JA, Favaro P, Saad ST. Eur J Cancer. 2015 Jan;51(2):252-9. doi: 10.1016/j.ejca.2014.11.012. Epub 2014 Dec 4. PubMed
Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Shim HS, Wei M, Brandhorst S, Longo VD. Cancer Res. 2015 Mar 15;75(6):1056-67. doi: 10.1158/0008-5472.CAN-14-2249. Epub 2015 Jan 22. PubMed
PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function. Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, Cetin Atalay R, Sakaguchi S, Ellmeier W, Erman B. Mol Cell Biol. 2015 May;35(10):1741-53. doi: 10.1128/MCB.01475-14. Epub 2015 Mar 9. PubMed
CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. Zhang S, Lu Z, Mao W, Ahmed AA, Yang H, Zhou J, Jennings N, Rodriguez-Aguayo C, Lopez-Berestein G, Miranda R, Qiao W, Baladandayuthapani V, Li Z, Sood AK, Liu J, Le XF, Bast RC Jr. PLoS One. 2015 Jul 6;10(7):e0131833. doi: 10.1371/journal.pone.0131833. eCollection 2015. PubMed
Functional activation of PPARgamma in human upper aerodigestive cancer cell lines. Wright SK, Wuertz BR, Harris G, Abu Ghazallah R, Miller WA, Gaffney PM, Ondrey FG. Mol Carcinog. 2016 Mar 21. doi: 10.1002/mc.22479. PubMed
MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Pereira DM, Simoes AE, Gomes SE, Castro RE, Carvalho T, Rodrigues CM, Borralho PM. Oncotarget. 2016 Jun 7;7(23):34322-40. doi: 10.18632/oncotarget.9107. PubMed
Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth. Aggarwal M, Saxena R, Sinclair E, Fu Y, Jacobs A, Dyba M, Wang X, Cruz I, Berry D, Kallakury B, Mueller SC, Agostino SD, Blandino G, Avantaggiati ML, Chung FL. Cell Death Differ. 2016 Jun 3. doi: 10.1038/cdd.2016.48. PubMed
Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells. Menendez D, Lowe JM, Snipe J, Resnick MA. Oncotarget. 2016 Sep 20;7(38):61630-61642. doi: 10.18632/oncotarget.11210. PubMed
Clinically Usable Interleukin 12 Plasmid without an Antibiotic Resistance Gene: Functionality and Toxicity Study in Murine Melanoma Model. Kamensek U, Tesic N, Sersa G, Cemazar M. Cancers (Basel). 2018 Feb 27;10(3). pii: cancers10030060. doi: 10.3390/cancers10030060. PubMed
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Xie W, Yang D. Cancer Cell. 2018 Apr 9;33(4):706-720.e9. doi: 10.1016/j.ccell.2018.03.006. Epub 2018 Apr 2. PubMed
Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53. Li JY, Liu CP, Shiao WC, Jayakumar T, Li YS, Chang NC, Huang SY, Hsieh CY. Arch Med Sci. 2018 Apr;14(3):579-587. doi: 10.5114/aoms.2018.75085. Epub 2018 Apr 16. PubMed
ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells. Wu Y, Li X, Yu J, Bjorkholm M, Xu D. Cell Death Dis. 2019 Jan 28;10(2):76. doi: 10.1038/s41419-019-1357-z. PubMed
HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress. Lee JJ, Park IH, Rhee WJ, Kim HS, Shin JS. FASEB J. 2019 Oct;33(10):10942-10953. doi: 10.1096/fj.201900288R. Epub 2019 Jul 5. PubMed
Inhibition of peptidyl-prolyl isomerase (PIN1) and BRAF signaling to target melanoma. Braun C, Schneider N, Pei D, Bosserhoff A, Kuphal S. Am J Transl Res. 2019 Jul 15;11(7):4425-4437. eCollection 2019. PubMed
Promyelocytic Leukemia (PML) gene regulation: implication towards curbing oncogenesis. Datta N, Islam S, Chatterjee U, Chatterjee S, Panda CK, Ghosh MK. Cell Death Dis. 2019 Sep 10;10(9):656. doi: 10.1038/s41419-019-1889-2. PubMed
WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade. Huang SW, Yang HY, Huang WJ, Chen WC, Yu MC, Wang SW, Hsu YF, Hsu MJ. Front Oncol. 2019 Nov 6;9:1188. doi: 10.3389/fonc.2019.01188. eCollection 2019. PubMed
Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signalling cascade. Huang SW, Chyuan IT, Shiue C, Yu MC, Hsu YF, Hsu MJ. J Cell Mol Med. 2020 Jan;24(2):1822-1836. doi: 10.1111/jcmm.14879. Epub 2019 Dec 10. PubMed
Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response. Strzeszewska-Potyrala A, Staniak K, Czarnecka-Herok J, Rafiee MR, Herok M, Mosieniak G, Krijgsveld J, Sikora E. Cancers (Basel). 2021 Apr 27;13(9). pii: cancers13092115. doi: 10.3390/cancers13092115. PubMed
Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study. Kos S, Bosnjak M, Jesenko T, Markelc B, Kamensek U, Znidar K, Matkovic U, Rencelj A, Sersa G, Hudej R, Tuljak A, Peterka M, Cemazar M. Pharmaceutics. 2021 Oct 19;13(10). pii: pharmaceutics13101739. doi: 10.3390/pharmaceutics13101739. PubMed
Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer. Iwai M, Kajino T, Nakatochi M, Yanagisawa K, Hosono Y, Isomura H, Shimada Y, Suzuki M, Taguchi A, Takahashi T. Oncogene. 2023 Jan;42(5):364-373. doi: 10.1038/s41388-022-02546-w. Epub 2022 Dec 15. PubMed
Loss of fragile WWOX gene leads to senescence escape and genome instability. Cheng HC, Huang PH, Lai FJ, Jan MS, Chen YL, Chen SY, Chen WL, Hsu CK, Huang W, Hsu LJ. Cell Mol Life Sci. 2023 Oct 28;80(11):338. doi: 10.1007/s00018-023-04950-1. PubMed

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