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HA-HIF2alpha-pcDNA3 Citations (18)

Originally described in: Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Cancer Cell. 2002 Apr . 1(3):237-46.
PubMed Journal

Articles Citing HA-HIF2alpha-pcDNA3

Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia. Zhuang Z, Yang C, Lorenzo F, Merino M, Fojo T, Kebebew E, Popovic V, Stratakis CA, Prchal JT, Pacak K. N Engl J Med. 2012 Sep 6;367(10):922-30. doi: 10.1056/NEJMoa1205119. PubMed
Proteostasis modulators prolong missense VHL protein activity and halt tumor progression. Yang C, Huntoon K, Ksendzovsky A, Zhuang Z, Lonser RR. Cell Rep. 2013 Jan 31;3(1):52-9. doi: 10.1016/j.celrep.2012.12.007. Epub 2013 Jan 10. PubMed
Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas. Yang C, Sun MG, Matro J, Huynh TT, Rahimpour S, Prchal JT, Lechan R, Lonser R, Pacak K, Zhuang Z. Blood. 2013 Mar 28;121(13):2563-6. doi: 10.1182/blood-2012-10-460972. Epub 2013 Jan 29. PubMed
HAF drives the switch of HIF-1alpha to HIF-2alpha by activating the NF-kappaB pathway, leading to malignant behavior of T24 bladder cancer cells. Guan Z, Ding C, Du Y, Zhang K, Zhu JN, Zhang T, He D, Xu S, Wang X, Fan J. Int J Oncol. 2014 Feb;44(2):393-402. doi: 10.3892/ijo.2013.2210. Epub 2013 Dec 6. PubMed
FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2alpha at the CYP51 promoter. Zhu J, Jiang X, Chehab FF. J Lipid Res. 2014 Mar;55(3):431-42. doi: 10.1194/jlr.M043521. Epub 2013 Dec 18. PubMed
Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation. Imagawa K, de Andres MC, Hashimoto K, Itoi E, Otero M, Roach HI, Goldring MB, Oreffo RO. Arthritis Rheumatol. 2014 Nov;66(11):3040-51. doi: 10.1002/art.38774. PubMed
Somatic gain-of-function HIF2A mutations in sporadic central nervous system hemangioblastomas. Taieb D, Barlier A, Yang C, Pertuit M, Tchoghandjian A, Rochette C, Zattara-Canoni H, Figarella-Branger D, Zhuang Z, Pacak K, Metellus P. J Neurooncol. 2016 Feb;126(3):473-81. doi: 10.1007/s11060-015-1983-y. Epub 2015 Oct 29. PubMed
HIF2A gain-of-function mutations detected in duodenal gangliocytic paraganglioma. Zhuang Z, Yang C, Ryska A, Ji Y, Hou Y, Graybill SD, Bullova P, Lubensky IA, Kloppel G, Pacak K. Endocr Relat Cancer. 2016 May;23(5):L13-6. doi: 10.1530/ERC-16-0148. Epub 2016 Apr 29. PubMed
Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Senavirathna LK, Huang C, Yang X, Munteanu MC, Sathiaseelan R, Xu D, Henke CA, Liu L. Sci Rep. 2018 Feb 9;8(1):2709. doi: 10.1038/s41598-018-21073-x. PubMed
The estrogen receptor variants beta2 and beta5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling. Faria M, Shepherd P, Pan Y, Chatterjee SS, Navone N, Gustafsson JA, Strom A. Oncotarget. 2018 Nov 20;9(91):36273-36288. doi: 10.18632/oncotarget.26345. eCollection 2018 Nov 20. PubMed
The Expression of CNS-Specific PPARGC1A Transcripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism. Soyal SM, Bonova P, Kwik M, Zara G, Auer S, Scharler C, Strunk D, Nofziger C, Paulmichl M, Patsch W. Mol Neurobiol. 2019 Aug 30. pii: 10.1007/s12035-019-01731-5. doi: 10.1007/s12035-019-01731-5. PubMed
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells. Yoo HC, Park SJ, Nam M, Kang J, Kim K, Yeo JH, Kim JK, Heo Y, Lee HS, Lee MY, Lee CW, Kang JS, Kim YH, Lee J, Choi J, Hwang GS, Bang S, Han JM. Cell Metab. 2020 Feb 4;31(2):267-283.e12. doi: 10.1016/j.cmet.2019.11.020. Epub 2019 Dec 19. PubMed
A novel germline gain-of-function HIF2A mutation in hepatocellular carcinoma with polycythemia. Yu J, Shi X, Yang C, Bullova P, Hong CS, Nesvick CL, Dmitriev P, Pacak K, Zhuang Z, Cao H, Li L. Aging (Albany NY). 2020 Apr 1;12(7):5781-5791. doi: 10.18632/aging.102967. Epub 2020 Apr 1. PubMed
A system-level approach identifies HIF-2alpha as a critical regulator of chondrosarcoma progression. Kim H, Cho Y, Kim HS, Kang D, Cheon D, Kim YJ, Chang MJ, Lee KM, Chang CB, Kang SB, Kang HG, Kim JH. Nat Commun. 2020 Oct 6;11(1):5023. doi: 10.1038/s41467-020-18817-7. PubMed
Hypoxia-Inducible Factor 1 Alpha-Mediated RelB/APOBEC3B Down-regulation Allows Hepatitis B Virus Persistence. Riedl T, Faure-Dupuy S, Rolland M, Schuehle S, Hizir Z, Calderazzo S, Zhuang X, Wettengel J, Lopez MA, Barnault R, Mirakaj V, Prokosch S, Heide D, Leuchtenberger C, Schneider M, Hessling B, Stottmeier B, Wessbecher IM, Schirmacher P, McKeating JA, Protzer U, Durantel D, Lucifora J, Dejardin E, Heikenwalder M. Hepatology. 2021 May 15. doi: 10.1002/hep.31902. PubMed
DYRK3 contributes to differentiation and hypoxic control in neuroblastoma. Ivanova E, Sharma SD, Brichkina A, Pfefferle P, Keber U, Pagenstecher A, Lauth M. Biochem Biophys Res Commun. 2021 Aug 27;567:215-221. doi: 10.1016/j.bbrc.2021.06.053. Epub 2021 Jun 22. PubMed
RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53. Jacquier V, Gitenay D, Fritsch S, Bonnet S, Gyorffy B, Jalaguier S, Linares LK, Cavailles V, Teyssier C. Cell Mol Life Sci. 2022 May 3;79(5):270. doi: 10.1007/s00018-022-04277-3. PubMed
CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1-positive regulator for tumor immune evasion. Wang S, Iyer R, Han X, Wei J, Li N, Cheng Y, Zhou Y, Gao Q, Zhang L, Yan M, Sun Z, Fang D. J Clin Invest. 2023 Dec 1;133(23):e167728. doi: 10.1172/JCI167728. PubMed

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