pLKO mouse shRNA 1 raptor Citations (48)
Originally described in: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS J Biol Chem. 2009 Mar 20. 284(12):8023-32. PubMed Journal
Articles Citing pLKO mouse shRNA 1 raptor
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| Deficiency in mTORC1-controlled C/EBPbeta-mRNA translation improves metabolic health in mice. Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang ZQ, von Maltzahn J, Muller C, Calkhoven CF. EMBO Rep. 2015 Aug;16(8):1022-36. doi: 10.15252/embr.201439837. Epub 2015 Jun 25. PubMed |
| DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase. Srinivas KP, Viji R, Dan VM, Sajitha IS, Prakash R, Rahul PV, Santhoshkumar TR, Lakshmi S, Pillai MR. Oncotarget. 2016 Apr 26;7(17):24154-71. doi: 10.18632/oncotarget.8131. PubMed |
| mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS. Alzheimers Dement. 2016 Sep 29. pii: S1552-5260(16)32895-3. doi: 10.1016/j.jalz.2016.08.015. PubMed |
| NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Rai R, Hu C, Broton C, Chen Y, Lei M, Chang S. Mol Cell. 2017 Mar 2;65(5):801-817.e4. doi: 10.1016/j.molcel.2017.01.016. Epub 2017 Feb 16. PubMed |
| CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development. Dillon GM, Tyler WA, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U, Ho A. Neuron. 2017 Mar 22;93(6):1344-1358.e5. doi: 10.1016/j.neuron.2017.02.039. Epub 2017 Mar 9. PubMed |
| Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. Pan Y, Smithson LJ, Ma Y, Hambardzumyan D, Gutmann DH. Oncotarget. 2017 May 16;8(20):32977-32989. doi: 10.18632/oncotarget.16516. PubMed |
| Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission. Do-Monte FH, Minier-Toribio A, Quinones-Laracuente K, Medina-Colon EM, Quirk GJ. Neuron. 2017 Apr 19;94(2):388-400.e4. doi: 10.1016/j.neuron.2017.03.036. PubMed |
| Biased Oxytocinergic Modulation of Midbrain Dopamine Systems. Xiao L, Priest MF, Nasenbeny J, Lu T, Kozorovitskiy Y. Neuron. 2017 Jul 19;95(2):368-384.e5. doi: 10.1016/j.neuron.2017.06.003. Epub 2017 Jun 29. PubMed |
| Epitranscriptomic m(6)A Regulation of Axon Regeneration in the Adult Mammalian Nervous System. Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, Dore LC, Dong Q, Zheng W, Jin P, Wu H, Shen B, Zhuang X, He C, Liu K, Song H, Ming GL. Neuron. 2018 Jan 17;97(2):313-325.e6. doi: 10.1016/j.neuron.2017.12.036. PubMed |
Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.
Ryan VH, Dignon GL, Zerze GH, Chabata CV, Silva R, Conicella AE, Amaya J, Burke KA, Mittal J, Fawzi NL.
Mol Cell. 2018 Jan 17. pii: S1097-2765(17)30979-6. doi: 10.1016/j.molcel.2017.12.022.
PubMed
Associated Plasmids |
| Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed |
| Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence. Urbano R, Karlinsey JE, Libby SJ, Doulias PT, Ischiropoulos H, Warheit-Niemi HI, Liggitt DH, Horswill AR, Fang FC. Cell Host Microbe. 2018 May 9;23(5):594-606.e7. doi: 10.1016/j.chom.2018.04.001. PubMed |
| Cas4 Nucleases Define the PAM, Length, and Orientation of DNA Fragments Integrated at CRISPR Loci. Shiimori M, Garrett SC, Graveley BR, Terns MP. Mol Cell. 2018 Jun 7;70(5):814-824.e6. doi: 10.1016/j.molcel.2018.05.002. Epub 2018 Jun 7. PubMed |
| Four Key Steps Control Glycolytic Flux in Mammalian Cells. Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD. Cell Syst. 2018 Jul 25;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. Epub 2018 Jun 27. PubMed |
| ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer. Harwood FC, Klein Geltink RI, O'Hara BP, Cardone M, Janke L, Finkelstein D, Entin I, Paul L, Houghton PJ, Grosveld GC. Sci Adv. 2018 Sep 12;4(9):eaar3938. doi: 10.1126/sciadv.aar3938. eCollection 2018 Sep. PubMed |
| A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers. Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. EMBO J. 2018 Nov 15;37(22):e100241. doi: 10.15252/embj.2018100241. Epub 2018 Oct 22. PubMed |
| Mechanism of Regulation of Big-Conductance Ca(2+)-Activated K(+) Channels by mTOR Complex 2 in Podocytes. Wang Y, Tao J, Wang M, Yang L, Ning F, Xin H, Xu X, Cai H, Zhang W, Yu K, Zhang X. Front Physiol. 2019 Feb 28;10:167. doi: 10.3389/fphys.2019.00167. eCollection 2019. PubMed |
| A Strategic Approach for Fluorescence Imaging of Membrane Proteins in a Native-like Environment. Swiecicki JM, Santana JT, Imperiali B. Cell Chem Biol. 2019 Dec 3. pii: S2451-9456(19)30390-3. doi: 10.1016/j.chembiol.2019.11.008. PubMed |
| Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical Force. Kim J, Lee J, Jang J, Ye F, Hong SJ, Petrich BG, Ulmer TS, Kim C. Curr Biol. 2020 May 4;30(9):1614-1625.e5. doi: 10.1016/j.cub.2020.02.028. Epub 2020 Mar 12. PubMed |
| Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation. Yang F, Sun S, Wang C, Haas M, Yeo S, Guan JL. Br J Cancer. 2020 Jun;122(12):1791-1802. doi: 10.1038/s41416-020-0839-1. Epub 2020 Apr 27. PubMed |
| SCARLET: Single-cell tumor phylogeny inference with copy-number constrained mutation losses. Satas G, Zaccaria S, Mon G, Raphael BJ. Cell Syst. 2020 Apr 22;10(4):323-332.e8. doi: 10.1016/j.cels.2020.04.001. PubMed |
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J.
Nat Commun. 2020 Nov 30;11(1):6088. doi: 10.1038/s41467-020-19937-w.
PubMed
Associated Plasmids |
| Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms. Kondo H, Ratcliffe CDH, Hooper S, Ellis J, MacRae JI, Hennequart M, Dunsby CW, Anderson KI, Sahai E. Cell Rep. 2021 Feb 16;34(7):108750. doi: 10.1016/j.celrep.2021.108750. PubMed |
| Molecules and fossils tell distinct yet complementary stories of mammal diversification. Upham NS, Esselstyn JA, Jetz W. Curr Biol. 2021 Oct 11;31(19):4195-4206.e3. doi: 10.1016/j.cub.2021.07.012. Epub 2021 Jul 29. PubMed |
| Complex species and strain ecology of the vaginal microbiome from pregnancy to postpartum and association with preterm birth. Pace RM, Chu DM, Prince AL, Ma J, Seferovic MD, Aagaard KM. Med. 2021 Sep 10;2(9):1027-1049. doi: 10.1016/j.medj.2021.06.001. Epub 2021 Jul 1. PubMed |
Rheb regulates nuclear mTORC1 activity independent of farnesylation.
Zhong Y, Zhou X, Guan KL, Zhang J.
Cell Chem Biol. 2022 Jun 16;29(6):1037-1045.e4. doi: 10.1016/j.chembiol.2022.02.006. Epub 2022 Mar 15.
PubMed
Associated Plasmids |
| mTORC2 suppresses cell death induced by hypo-osmotic stress by promoting sphingomyelin transport. Ono Y, Matsuzawa K, Ikenouchi J. J Cell Biol. 2022 Apr 4;221(4):e202106160. doi: 10.1083/jcb.202106160. Epub 2022 Mar 23. PubMed |
| Sequence and chromatin features guide DNA double-strand break resection initiation. Gnugge R, Reginato G, Cejka P, Symington LS. Mol Cell. 2023 Apr 20;83(8):1237-1250.e15. doi: 10.1016/j.molcel.2023.02.010. Epub 2023 Mar 13. PubMed |
High-throughput discovery and characterization of viral transcriptional effectors in human cells.
Ludwig CH, Thurm AR, Morgens DW, Yang KJ, Tycko J, Bassik MC, Glaunsinger BA, Bintu L.
Cell Syst. 2023 Jun 21;14(6):482-500.e8. doi: 10.1016/j.cels.2023.05.008.
PubMed
Associated Plasmids |
| The genomic basis of temporal niche evolution in a diurnal rodent. Richardson R, Feigin CY, Bano-Otalora B, Johnson MR, Allen AE, Park J, McDowell RJ, Mereby SA, Lin IH, Lucas RJ, Mallarino R. Curr Biol. 2023 Aug 7;33(15):3289-3298.e6. doi: 10.1016/j.cub.2023.06.068. Epub 2023 Jul 21. PubMed |
| Anti-Hebbian plasticity in the motor cortex promotes defensive freezing. Bai Y, Grier B, Geron E. Curr Biol. 2023 Aug 21;33(16):3465-3477.e5. doi: 10.1016/j.cub.2023.07.021. Epub 2023 Aug 4. PubMed |
| Preterm birth and detection of common respiratory pathogens among pediatric pneumonia. Wang XR, Du J, Zhang SS, Zhang WX, Zhang XA, Lu QB, Ren L, Liu W, Liu EM. iScience. 2023 Jul 27;26(9):107488. doi: 10.1016/j.isci.2023.107488. eCollection 2023 Sep 15. PubMed |
| Evolutionarily conserved behavioral plasticity enables context-dependent mating in C. elegans. Susoy V, Samuel ADT. Curr Biol. 2023 Oct 23;33(20):4532-4537.e3. doi: 10.1016/j.cub.2023.09.003. Epub 2023 Sep 27. PubMed |
| YOLOX-DG robotic detection systems for large-scale underwater concrete structures. Zhang C, Ma H, Chen Z, Li S, Ma Z, Huang H, Zhu R, Jiao P. iScience. 2024 Feb 28;27(4):109337. doi: 10.1016/j.isci.2024.109337. eCollection 2024 Apr 19. PubMed |
| Transcriptome regulation by PARP13 in basal and antiviral states in human cells. Busa VF, Ando Y, Aigner S, Yee BA, Yeo GW, Leung AKL. iScience. 2024 Feb 16;27(4):109251. doi: 10.1016/j.isci.2024.109251. eCollection 2024 Apr 19. PubMed |
| Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection. Sakai M, Masuda Y, Tarumoto Y, Aihara N, Tsunoda Y, Iwata M, Kamiya Y, Komorizono R, Noda T, Yusa K, Tomonaga K, Makino A. iScience. 2024 Jul 8;27(8):110475. doi: 10.1016/j.isci.2024.110475. eCollection 2024 Aug 16. PubMed |
| National antibiotic consumption is strongly related to the prevalence of antibiotic resistance across bacterial clades. Louca S. iScience. 2025 Jan 6;28(2):111712. doi: 10.1016/j.isci.2024.111712. eCollection 2025 Feb 21. PubMed |
| Substrate diffusion electrodes allow for the electrochemical hydrogenation of concentrated alkynol substrate feeds. Wolf J, Shahrour F, Acar Z, Pellumbi K, Kleinhaus JT, Wickert L, Apfel UP, Siegmund D. iScience. 2025 Jan 10;28(2):111789. doi: 10.1016/j.isci.2025.111789. eCollection 2025 Feb 21. PubMed |
| Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types. Meitil IKS, de O G Silva C, Pedersen AG, Agger JW. iScience. 2025 Jan 10;28(2):111771. doi: 10.1016/j.isci.2025.111771. eCollection 2025 Feb 21. PubMed |
| SENP2-based N-terminal truncation of alpha-synuclein in Lewy pathology propagation. Taguchi K, Watanabe Y, Tanaka M. iScience. 2025 Jan 31;28(2):111935. doi: 10.1016/j.isci.2025.111935. eCollection 2025 Feb 21. PubMed |
| Formation of brain-wide neural geometry during visual item recognition in monkeys. Chen H, Kunimatsu J, Oya T, Imaizumi Y, Hori Y, Matsumoto M, Tsubo Y, Hikosaka O, Minamimoto T, Naya Y, Yamada H. iScience. 2025 Jan 31;28(3):111936. doi: 10.1016/j.isci.2025.111936. eCollection 2025 Mar 21. PubMed |
| Unsupervised spatiotemporal classification of deformation patterns of embryonic tissues matches their fate map. Pastor-Escuredo D, Lombardot B, Savy T, Boyreau A, Doursat R, Goicolea JM, Santos A, Bourgine P, Del Alamo JC, Ledesma-Carbayo MJ, Peyrieras N. iScience. 2025 Jan 9;28(3):111753. doi: 10.1016/j.isci.2025.111753. eCollection 2025 Mar 21. PubMed |
| Predictable sequential structure augments auditory sensitivity at threshold. Marin N, Gerenton G, Jean H, Paraouty N, Wallaert N, Lazard DS, Doelling KB, Arnal LH. iScience. 2025 Feb 20;28(3):112074. doi: 10.1016/j.isci.2025.112074. eCollection 2025 Mar 21. PubMed |
| Semantic and relation aware neural network model for bi-class multi-relational heterogeneous graphs. Zhao Y, Liu H, Duan H. iScience. 2025 Mar 7;28(4):112155. doi: 10.1016/j.isci.2025.112155. eCollection 2025 Apr 18. PubMed |
| Net zero in power and industry-creating or destroying value and jobs? Ganzer C, Patrizio P, Mac Dowell N. iScience. 2025 Mar 10;28(4):112185. doi: 10.1016/j.isci.2025.112185. eCollection 2025 Apr 18. PubMed |
| Origin and development of uniparental and polyploid blastomeres. Zhao Y, Fernandez-Montoro A, Peeters G, Jatsenko T, De Coster T, Angel-Velez D, Lefevre T, Voet T, Tsuiko O, Kurg A, Smits K, Van Soom A, Vermeesch JR. iScience. 2025 Apr 2;28(5):112337. doi: 10.1016/j.isci.2025.112337. eCollection 2025 May 16. PubMed |
| Protection of infant mice against pertussis, tuberculosis and influenza by co-administration of nasal pertussis vaccine candidate BPZE1 and BCG. Rouanet C, Debrie AS, Cauchi S, Mielcarek N. iScience. 2025 Jun 7;28(7):112839. doi: 10.1016/j.isci.2025.112839. eCollection 2025 Jul 18. PubMed |
| A tumor microenvironment model for glioma diagnosis and therapeutic evaluation based on the analysis of tissues and biological fluids. Zhang Q, Chi H, Qi Y, Zhao R, Xue F, Li G, Xue H. iScience. 2025 Jun 13;28(7):112881. doi: 10.1016/j.isci.2025.112881. eCollection 2025 Jul 18. PubMed |
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