pLKO mouse shRNA 1 raptor Citations (30)
Originally described in: An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS J Biol Chem. 2009 Mar 20. 284(12):8023-32. PubMed Journal
Articles Citing pLKO mouse shRNA 1 raptor
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| Deficiency in mTORC1-controlled C/EBPbeta-mRNA translation improves metabolic health in mice. Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang ZQ, von Maltzahn J, Muller C, Calkhoven CF. EMBO Rep. 2015 Aug;16(8):1022-36. doi: 10.15252/embr.201439837. Epub 2015 Jun 25. PubMed |
| DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase. Srinivas KP, Viji R, Dan VM, Sajitha IS, Prakash R, Rahul PV, Santhoshkumar TR, Lakshmi S, Pillai MR. Oncotarget. 2016 Apr 26;7(17):24154-71. doi: 10.18632/oncotarget.8131. PubMed |
| mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS. Alzheimers Dement. 2016 Sep 29. pii: S1552-5260(16)32895-3. doi: 10.1016/j.jalz.2016.08.015. PubMed |
| CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development. Dillon GM, Tyler WA, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U, Ho A. Neuron. 2017 Mar 22;93(6):1344-1358.e5. doi: 10.1016/j.neuron.2017.02.039. Epub 2017 Mar 9. PubMed |
| Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. Pan Y, Smithson LJ, Ma Y, Hambardzumyan D, Gutmann DH. Oncotarget. 2017 May 16;8(20):32977-32989. doi: 10.18632/oncotarget.16516. PubMed |
| ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer. Harwood FC, Klein Geltink RI, O'Hara BP, Cardone M, Janke L, Finkelstein D, Entin I, Paul L, Houghton PJ, Grosveld GC. Sci Adv. 2018 Sep 12;4(9):eaar3938. doi: 10.1126/sciadv.aar3938. eCollection 2018 Sep. PubMed |
| A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers. Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. EMBO J. 2018 Nov 15;37(22):e100241. doi: 10.15252/embj.2018100241. Epub 2018 Oct 22. PubMed |
| Mechanism of Regulation of Big-Conductance Ca(2+)-Activated K(+) Channels by mTOR Complex 2 in Podocytes. Wang Y, Tao J, Wang M, Yang L, Ning F, Xin H, Xu X, Cai H, Zhang W, Yu K, Zhang X. Front Physiol. 2019 Feb 28;10:167. doi: 10.3389/fphys.2019.00167. eCollection 2019. PubMed |
| A Strategic Approach for Fluorescence Imaging of Membrane Proteins in a Native-like Environment. Swiecicki JM, Santana JT, Imperiali B. Cell Chem Biol. 2019 Dec 3. pii: S2451-9456(19)30390-3. doi: 10.1016/j.chembiol.2019.11.008. PubMed |
| Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation. Yang F, Sun S, Wang C, Haas M, Yeo S, Guan JL. Br J Cancer. 2020 Jun;122(12):1791-1802. doi: 10.1038/s41416-020-0839-1. Epub 2020 Apr 27. PubMed |
| ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA. Dumesic PA, Stoddard CI, Catania S, Narlikar GJ, Madhani HD. Mol Cell. 2020 Jul 2;79(1):127-139.e4. doi: 10.1016/j.molcel.2020.04.029. Epub 2020 May 20. PubMed |
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J.
Nat Commun. 2020 Nov 30;11(1):6088. doi: 10.1038/s41467-020-19937-w.
PubMed
Associated Plasmids |
| Neurally driven synthesis of learned, complex vocalizations. Arneodo EM, Chen S, Brown DE 2nd, Gilja V, Gentner TQ. Curr Biol. 2021 Aug 9;31(15):3419-3425.e5. doi: 10.1016/j.cub.2021.05.035. Epub 2021 Jun 16. PubMed |
| Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Woo V, Eshleman EM, Hashimoto-Hill S, Whitt J, Wu SE, Engleman L, Rice T, Karns R, Qualls JE, Haslam DB, Vallance BA, Alenghat T. Cell Host Microbe. 2021 Dec 8;29(12):1744-1756.e5. doi: 10.1016/j.chom.2021.09.010. Epub 2021 Oct 21. PubMed |
Rheb regulates nuclear mTORC1 activity independent of farnesylation.
Zhong Y, Zhou X, Guan KL, Zhang J.
Cell Chem Biol. 2022 Jun 16;29(6):1037-1045.e4. doi: 10.1016/j.chembiol.2022.02.006. Epub 2022 Mar 15.
PubMed
Associated Plasmids |
| mTORC2 suppresses cell death induced by hypo-osmotic stress by promoting sphingomyelin transport. Ono Y, Matsuzawa K, Ikenouchi J. J Cell Biol. 2022 Apr 4;221(4):e202106160. doi: 10.1083/jcb.202106160. Epub 2022 Mar 23. PubMed |
| The impact of familiarity on cortical taste coding. Staszko SM, Boughter JD Jr, Fletcher ML. Curr Biol. 2022 Nov 21;32(22):4914-4924.e4. doi: 10.1016/j.cub.2022.09.053. Epub 2022 Oct 18. PubMed |
| ImmunoTyper-SR: A computational approach for genotyping immunoglobulin heavy chain variable genes using short-read data. Ford MKB, Hari A, Rodriguez O, Xu J, Lack J, Oguz C, Zhang Y, Weber S, Magliocco M, Barnett J, Xirasagar S, Samuel S, Imberti L, Bonfanti P, Biondi A, Dalgard CL, Chanock S, Rosen L, Holland S, Su H, Notarangelo L, Vishkin U, Watson CT, Sahinalp SC. Cell Syst. 2022 Oct 19;13(10):808-816.e5. doi: 10.1016/j.cels.2022.08.008. PubMed |
| Feature representation under crowding in macaque V1 and V4 neuronal populations. Henry CA, Kohn A. Curr Biol. 2022 Dec 5;32(23):5126-5137.e3. doi: 10.1016/j.cub.2022.10.049. Epub 2022 Nov 14. PubMed |
| The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks. DePasquale B, Sussillo D, Abbott LF, Churchland MM. Neuron. 2023 Mar 1;111(5):631-649.e10. doi: 10.1016/j.neuron.2022.12.007. Epub 2023 Jan 10. PubMed |
| The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Robert SM, Reeves BC, Kiziltug E, Duy PQ, Karimy JK, Mansuri MS, Marlier A, Allington G, Greenberg ABW, DeSpenza T Jr, Singh AK, Zeng X, Mekbib KY, Kundishora AJ, Nelson-Williams C, Hao LT, Zhang J, Lam TT, Wilson R, Butler WE, Diluna ML, Feinberg P, Schafer DP, Movahedi K, Tannenbaum A, Koundal S, Chen X, Benveniste H, Limbrick DD Jr, Schiff SJ, Carter BS, Gunel M, Simard JM, Lifton RP, Alper SL, Delpire E, Kahle KT. Cell. 2023 Feb 16;186(4):764-785.e21. doi: 10.1016/j.cell.2023.01.017. PubMed |
| Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells. Kisty EA, Falco JA, Weerapana E. Cell Chem Biol. 2023 Mar 16;30(3):321-336.e6. doi: 10.1016/j.chembiol.2023.02.006. Epub 2023 Mar 7. PubMed |
| Oxylipin-PPARgamma-initiated adipocyte senescence propagates secondary senescence in the bone marrow. Liu X, Gu Y, Kumar S, Amin S, Guo Q, Wang J, Fang CL, Cao X, Wan M. Cell Metab. 2023 Apr 4;35(4):667-684.e6. doi: 10.1016/j.cmet.2023.03.005. PubMed |
| Pyruvate-supported flux through medium-chain ketothiolase promotes mitochondrial lipid tolerance in cardiac and skeletal muscles. Koves TR, Zhang GF, Davidson MT, Chaves AB, Crown SB, Johnson JM, Slentz DH, Grimsrud PA, Muoio DM. Cell Metab. 2023 Jun 6;35(6):1038-1056.e8. doi: 10.1016/j.cmet.2023.03.016. Epub 2023 Apr 14. PubMed |
| The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia. Schluter J, Djukovic A, Taylor BP, Yan J, Duan C, Hussey GA, Liao C, Sharma S, Fontana E, Amoretti LA, Wright RJ, Dai A, Peled JU, Taur Y, Perales MA, Siranosian BA, Bhatt AS, van den Brink MRM, Pamer EG, Xavier JB. Cell Host Microbe. 2023 Jul 12;31(7):1126-1139.e6. doi: 10.1016/j.chom.2023.05.027. Epub 2023 Jun 16. PubMed |
| Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys. Sanzeni A, Palmigiano A, Nguyen TH, Luo J, Nassi JJ, Reynolds JH, Histed MH, Miller KD, Brunel N. Neuron. 2023 Dec 20;111(24):4102-4115.e9. doi: 10.1016/j.neuron.2023.09.018. Epub 2023 Oct 20. PubMed |
| Parallel neural pathways control sodium consumption and taste valence. Zhang Y, Pool AH, Wang T, Liu L, Kang E, Zhang B, Ding L, Frieda K, Palmiter R, Oka Y. Cell. 2023 Dec 21;186(26):5751-5765.e16. doi: 10.1016/j.cell.2023.10.020. Epub 2023 Nov 20. PubMed |
| Plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection. Wang S, He B, Wu H, Cai Q, Ramirez-Sanchez O, Abreu-Goodger C, Birch PRJ, Jin H. Cell Host Microbe. 2024 Jan 10;32(1):93-105.e6. doi: 10.1016/j.chom.2023.11.020. Epub 2023 Dec 15. PubMed |
| Dissociable neuronal substrates of visual feature attention and working memory. Mendoza-Halliday D, Xu H, Azevedo FAC, Desimone R. Neuron. 2024 Mar 6;112(5):850-863.e6. doi: 10.1016/j.neuron.2023.12.007. Epub 2024 Jan 15. PubMed |
| Multiplexed dynamic control of temperature to probe and observe mammalian cells. Benman W, Iyengar P, Mumford TR, Huang Z, Kapoor M, Liu G, Bugaj LJ. Cell Syst. 2025 Mar 19;16(3):101234. doi: 10.1016/j.cels.2025.101234. Epub 2025 Mar 12. PubMed |
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