Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected]. Learn more


EF.STAT3C.Ubc.GFP Citations (43)

Originally described in: The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?
Hillion J, Dhara S, Sumter TF, Mukherjee M, Di Cello F, Belton A, Turkson J, Jaganathan S, Cheng L, Ye Z, Jove R, Aplan P, Lin YW, Wertzler K, Reeves R, Elbahlouh O, Kowalski J, Bhattacharya R, Resar LM. Cancer Research 68, 10121, December 2008.
PubMed Journal

Articles Citing EF.STAT3C.Ubc.GFP

Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease. Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC. J Immunol. 2013 Nov 1;191(9):4867-79. doi: 10.4049/jimmunol.1300588. Epub 2013 Sep 30. PubMed
STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious. Maycotte P, Gearheart CM, Barnard R, Aryal S, Mulcahy Levy JM, Fosmire SP, Hansen RJ, Morgan MJ, Porter CC, Gustafson DL, Thorburn A. Cancer Res. 2014 May 1;74(9):2579-90. doi: 10.1158/0008-5472.CAN-13-3470. Epub 2014 Mar 3. PubMed
Targeting signal transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and -induced apoptosis of human lung cancer cells. Zhou Y, Tang Q, Zhao S, Zhang F, Li L, Wu W, Wang Z, Hann S. Tumour Biol. 2014 Aug;35(8):8169-78. doi: 10.1007/s13277-014-2047-1. Epub 2014 May 21. PubMed
Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling. Choi YK, Cho SG, Woo SM, Yun YJ, Park S, Shin YC, Ko SG. Mediators Inflamm. 2014;2014:492173. doi: 10.1155/2014/492173. Epub 2014 May 25. PubMed
MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2. Nowak DG, Cho H, Herzka T, Watrud K, DeMarco DV, Wang VM, Senturk S, Fellmann C, Ding D, Beinortas T, Kleinman D, Chen M, Sordella R, Wilkinson JE, Castillo-Martin M, Cordon-Cardo C, Robinson BD, Trotman LC. Cancer Discov. 2015 Jun;5(6):636-51. doi: 10.1158/2159-8290.CD-14-1113. Epub 2015 Mar 31. PubMed
Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Cao W, Liu Y, Zhang R, Zhang B, Wang T, Zhu X, Mei L, Chen H, Zhang H, Ming P, Huang L. Sci Rep. 2015 Jul 13;5:8477. doi: 10.1038/srep08477. PubMed
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, Okimoto RA, Lin L, Neel DS, Sabnis A, Flanagan J, Chan E, Varella-Garcia M, Aisner DL, Vaishnavi A, Ou SH, Collisson EA, Ichihara E, Mack PC, Lovly CM, Karachaliou N, Rosell R, Riess JW, Doebele RC, Bivona TG. Nat Med. 2015 Sep;21(9):1038-47. doi: 10.1038/nm.3930. Epub 2015 Aug 24. PubMed
Molecular identity of human outer radial glia during cortical development. Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim DA, Leyrat AA, West JA, Kriegstein AR. Cell. 2015 Sep 24;163(1):55-67. doi: 10.1016/j.cell.2015.09.004. PubMed
p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling. Tyagi N, Marimuthu S, Bhardwaj A, Deshmukh SK, Srivastava SK, Singh AP, McClellan S, Carter JE, Singh S. Cancer Lett. 2016 Jan 28;370(2):260-7. doi: 10.1016/j.canlet.2015.10.028. Epub 2015 Nov 3. PubMed
Essential role of HDAC6 in the regulation of PD-L1 in melanoma. Lienlaf M, Perez-Villarroel P, Knox T, Pabon M, Sahakian E, Powers J, Woan KV, Lee C, Cheng F, Deng S, Smalley KS, Montecino M, Kozikowski A, Pinilla-Ibarz J, Sarnaik A, Seto E, Weber J, Sotomayor EM, Villagra A. Mol Oncol. 2016 May;10(5):735-50. doi: 10.1016/j.molonc.2015.12.012. Epub 2016 Jan 6. PubMed
Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival. Tiong KH, Tan BS, Choo HL, Chung FF, Hii LW, Tan SH, Khor NT, Wong SF, See SJ, Tan YF, Rosli R, Cheong SK, Leong CO. Oncotarget. 2016 Sep 6;7(36):57633-57650. doi: 10.18632/oncotarget.9328. PubMed
Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice. Sun F, Zhang ZW, Tan EM, Lim ZL, Li Y, Wang XC, Chua SE, Li J, Cheung E, Yong EL. Carcinogenesis. 2016 Jul;37(7):701-11. doi: 10.1093/carcin/bgw044. Epub 2016 Apr 19. PubMed
miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis. Xue J, Zhou A, Wu Y, Morris SA, Lin K, Amin S, Verhaak R, Fuller G, Xie K, Heimberger AB, Huang S. Cancer Res. 2016 May 31. PubMed
SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes. Choi YK, Cho SG, Choi YJ, Yun YJ, Lee KM, Lee K, Yoo HH, Shin YC, Ko SG. Oncotarget. 2016 Aug 19. doi: 10.18632/oncotarget.11393. PubMed
Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma. Rui L, Drennan AC, Ceribelli M, Zhu F, Wright GW, Huang DW, Xiao W, Li Y, Grindle KM, Lu L, Hodson DJ, Shaffer AL, Zhao H, Xu W, Yang Y, Staudt LM. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7260-E7267. Epub 2016 Oct 31. PubMed
Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. van Andel H, Ren Z, Koopmans I, Joosten SP, Kocemba KA, de Lau W, Kersten MJ, de Bruin AM, Guikema JE, Clevers H, Spaargaren M, Pals ST. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):376-381. doi: 10.1073/pnas.1618650114. Epub 2016 Dec 27. PubMed
Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis. Chuang CH, Greenside PG, Rogers ZN, Brady JJ, Yang D, Ma RK, Caswell DR, Chiou SH, Winters AF, Gruner BM, Ramaswami G, Spencley AL, Kopecky KE, Sayles LC, Sweet-Cordero EA, Li JB, Kundaje A, Winslow MM. Nat Med. 2017 Mar;23(3):291-300. doi: 10.1038/nm.4285. Epub 2017 Feb 13. PubMed
Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells. Wang ST, Ho HJ, Lin JT, Shieh JJ, Wu CY. Cell Death Dis. 2017 Feb 23;8(2):e2626. doi: 10.1038/cddis.2016.472. PubMed
Stat3 regulates desmoglein 3 transcription in epithelial keratinocytes. Mao X, Cho MJT, Ellebrecht CT, Mukherjee EM, Payne AS. JCI Insight. 2017 May 4;2(9). pii: 92253. doi: 10.1172/jci.insight.92253. PubMed
Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma. Bixel K, Saini U, Kumar Bid H, Fowler J, Riley M, Wanner R, Deepa Priya Dorayappan K, Rajendran S, Konishi I, Matsumura N, Cohn DE, Selvendiran K. Int J Cancer. 2017 Jun 24. doi: 10.1002/ijc.30847. PubMed
The prenylflavonoid Icaritin enhances osteoblast proliferation and function by signal transducer and activator of transcription factor 3 (STAT-3) regulation of C-X-C chemokine receptor type 4 (CXCR4) expression. Lim R, Li L, Chew N, Yong EL. Bone. 2017 Dec;105:122-133. doi: 10.1016/j.bone.2017.08.028. Epub 2017 Aug 31. PubMed
SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes. Choi YK, Cho SG, Choi YJ, Yun YJ, Lee KM, Lee K, Yoo HH, Shin YC, Ko SG. Oncotarget. 2016 Aug 19;8(51):88386-88400. doi: 10.18632/oncotarget.11393. eCollection 2017 Oct 24. PubMed
STAT-3 regulation of CXCR4 is necessary for the prenylflavonoid Icaritin to enhance mesenchymal stem cell proliferation, migration and osteogenic differentiation. Lim RZL, Li L, Yong EL, Chew N. Biochim Biophys Acta Gen Subj. 2018 Jul;1862(7):1680-1692. doi: 10.1016/j.bbagen.2018.04.016. Epub 2018 Apr 19. PubMed
Role of the HDAC6/STAT3 pathway in regulating PD-L1 expression in osteosarcoma cell lines. Keremu A, Aimaiti A, Liang Z, Zou X. Cancer Chemother Pharmacol. 2019 Feb;83(2):255-264. doi: 10.1007/s00280-018-3721-6. Epub 2018 Nov 14. PubMed
Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells. Tzeng YT, Liu PF, Li JY, Liu LF, Kuo SY, Hsieh CW, Lee CH, Wu CH, Hsiao M, Chang HT, Shu CW. Front Pharmacol. 2018 Nov 9;9:1285. doi: 10.3389/fphar.2018.01285. eCollection 2018. PubMed
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. Sun H, Yang W, Tian Y, Zeng X, Zhou J, Mok MTS, Tang W, Feng Y, Xu L, Chan AWH, Tong JH, Cheung YS, Lai PBS, Wang HKS, Tsang SW, Chow KL, Hu M, Liu R, Huang L, Yang B, Yang P, To KF, Sung JJY, Wong GLH, Wong VWS, Cheng ASL. Nat Commun. 2018 Dec 6;9(1):5214. doi: 10.1038/s41467-018-07402-8. PubMed
Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Neel DS, Allegakoen DV, Olivas V, Mayekar MK, Hemmati G, Chatterjee N, Blakely CM, McCoach CE, Rotow JK, Le A, Karachaliou N, Rosell R, Riess JW, Nichols R, Doebele RC, Bivona TG. Cancer Res. 2019 Feb 1;79(3):546-556. doi: 10.1158/0008-5472.CAN-18-1492. Epub 2018 Dec 11. PubMed
Sustained NF-kappaB-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition. da Hora CC, Pinkham K, Carvalho L, Zinter M, Tabet E, Nakano I, Tannous BA, Badr CE. Cell Death Discov. 2019 Mar 4;5:72. doi: 10.1038/s41420-019-0155-9. eCollection 2019. PubMed
Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes. Sun S, Zhang X, Xu M, Zhang F, Tian F, Cui J, Xia Y, Liang C, Zhou S, Wei H, Zhao H, Wu G, Xu B, Liu X, Yang G, Wang Q, Zhang L, Gong Y, Shao C, Zou Y. Cell Death Dis. 2019 Mar 20;10(4):274. doi: 10.1038/s41419-019-1510-8. PubMed
Regulation of Differentiation of HC11 Mouse Breast Epithelial Cells by the Signal Transducer and Activator of Transcription-3. Niit M, Geletu M, Taha Z, Arulanandam R, Cass J, Hoskin V, Elliott B, Gunning P, Raptis L. Anticancer Res. 2019 Jun;39(6):2749-2756. doi: 10.21873/anticanres.13401. PubMed
Flavopereirine Suppresses the Growth of Colorectal Cancer Cells through P53 Signaling Dependence. Li JM, Huang YC, Kuo YH, Cheng CC, Kuan FC, Chang SF, Lee YR, Chin CC, Shi CS. Cancers (Basel). 2019 Jul 22;11(7). pii: cancers11071034. doi: 10.3390/cancers11071034. PubMed
Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma. Ji XL, He M. Aging (Albany NY). 2019 Aug 15;11(15):5848-5863. doi: 10.18632/aging.102193. Epub 2019 Aug 15. PubMed
Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF-1alpha-independent VEGF expression and angiogenesis in hepatocellular carcinoma. Zhang C, Wang N, Tan HY, Guo W, Chen F, Zhong Z, Man K, Tsao SW, Lao L, Feng Y. Br J Pharmacol. 2020 Jul;177(14):3240-3257. doi: 10.1111/bph.15046. Epub 2020 Apr 12. PubMed
The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling. Ma X, Wu K, Xu A, Jiao P, Li H, Xing L. Environ Toxicol Pharmacol. 2021 Jan;81:103513. doi: 10.1016/j.etap.2020.103513. Epub 2020 Oct 20. PubMed
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability. Wang L, Astone M, Alam SK, Zhu Z, Pei W, Frank DA, Burgess SM, Hoeppner LH. bioRxiv. 2020 Oct 28. doi: 10.1101/2020.10.27.358374. PubMed
SHCBP1 regulates STAT3/c-Myc signaling activation to promote tumor progression in penile cancer. Mo M, Tong S, Yin H, Jin Z, Zu X, Hu X. Am J Cancer Res. 2020 Oct 1;10(10):3138-3156. eCollection 2020. PubMed
Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells. Nalairndran G, Chung I, Abdul Razack AH, Chung FF, Hii LW, Lim WM, Looi CK, Mai CW, Leong CO. J Cell Mol Med. 2021 Sep;25(17):8187-8200. doi: 10.1111/jcmm.16684. Epub 2021 Jul 28. PubMed
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability. Wang L, Astone M, Alam SK, Zhu Z, Pei W, Frank DA, Burgess SM, Hoeppner LH. Dis Model Mech. 2021 Nov 1;14(11). pii: 272222. doi: 10.1242/dmm.049029. Epub 2021 Nov 11. PubMed
BRD4 Regulates Transcription Factor DeltaNp63alpha to Drive a Cancer Stem Cell Phenotype in Squamous Cell Carcinomas. Fisher ML, Balinth S, Hwangbo Y, Wu C, Ballon C, Wilkinson JE, Goldberg GL, Mills AA. Cancer Res. 2021 Dec 15;81(24):6246-6258. doi: 10.1158/0008-5472.CAN-21-0707. Epub 2021 Oct 25. PubMed
The endosomal pH regulator NHE9 is a driver of stemness in glioblastoma. Ko M, Makena MR, Schiapparelli P, Suarez-Meade P, Mekile AX, Lal B, Lopez-Bertoni H, Kozielski KL, Green JJ, Laterra J, Quinones-Hinojosa A, Rao R. PNAS Nexus. 2022 Mar 9;1(1):pgac013. doi: 10.1093/pnasnexus/pgac013. eCollection 2022 Mar. PubMed
Niraparib-induced STAT3 inhibition increases its antitumor effects. Zhao Q, Kohut A, Li YJ, Martincuks A, Austria T, Zhang C, Santiago NL, Borrero RM, Phan XT, Melstrom L, Rodriguez-Rodriguez L, Yu H. Front Oncol. 2022 Oct 17;12:966492. doi: 10.3389/fonc.2022.966492. eCollection 2022. PubMed
IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma. Kunhiraman H, McSwain L, Shahab SW, Gershon TR, MacDonald TJ, Kenney AM. Acta Neuropathol Commun. 2023 Apr 8;11(1):62. doi: 10.1186/s40478-023-01557-2. PubMed
Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma. Fisher ML, Balinth S, Hwangbo Y, Wu C, Ballon C, Goldberg GL, Mills AA. Carcinogenesis. 2023 Aug 18;44(6):485-496. doi: 10.1093/carcin/bgad048. PubMed

If you have published an article using this material, please email us at [email protected] to have your article added to this page.