Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected]. Learn more


pCAX APP 695 Citations (21)

Originally described in: A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference.
Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ J Neurosci. 2007 Dec 26. 27(52):14459-69.
PubMed Journal

Articles Citing pCAX APP 695

Differential regulation of the high-affinity choline transporter by wild-type and Swedish mutant amyloid precursor protein. Cuddy LK, Seah C, Pasternak SH, Rylett RJ. J Neurochem. 2015 Aug;134(4):769-82. doi: 10.1111/jnc.13167. Epub 2015 Jun 3. PubMed
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Strilic B, Yang L, Albarran-Juarez J, Wachsmuth L, Han K, Muller UC, Pasparakis M, Offermanns S. Nature. 2016 Aug 11;536(7615):215-8. PubMed
APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease. Manocha GD, Floden AM, Rausch K, Kulas JA, McGregor BA, Rojanathammanee L, Puig KR, Puig KL, Karki S, Nichols MR, Darland DC, Porter JE, Combs CK. J Neurosci. 2016 Aug 10;36(32):8471-86. doi: 10.1523/JNEUROSCI.4654-15.2016. PubMed
Microscopic analysis of Orai-mediated store-operated calcium entry in cells with experimentally altered levels of amyloid precursor protein. Wegierski T, Gazda K, Kuznicki J. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1087-92. doi: 10.1016/j.bbrc.2016.08.072. Epub 2016 Aug 12. PubMed
Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AbetaPP into Amyloidogenic Processing Pathway. Fisher CL, Resnick RJ, De S, Acevedo LA, Lu KP, Schroeder FC, Nicholson LK. J Alzheimers Dis. 2017;55(1):391-410. PubMed
BECN1/Beclin 1 sorts cell-surface APP/amyloid beta precursor protein for lysosomal degradation. Swaminathan G, Zhu W, Plowey ED. Autophagy. 2016 Dec;12(12):2404-2419. Epub 2016 Oct 7. PubMed
Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Canu N, Pagano I, La Rosa LR, Pellegrino M, Ciotti MT, Mercanti D, Moretti F, Sposato V, Triaca V, Petrella C, Maruyama IN, Levi A, Calissano P. Front Mol Neurosci. 2017 Jan 31;10:15. doi: 10.3389/fnmol.2017.00015. eCollection 2017. PubMed
Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology. Pahrudin Arrozi A, Shukri SNS, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, Makpol S. Appl Biochem Biotechnol. 2017 Apr 17. doi: 10.1007/s12010-017-2468-6. PubMed
A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome. Hein LK, Apaja PM, Hattersley K, Grose RH, Xie J, Proud CG, Sargeant TJ. Biochim Biophys Acta. 2017 Jun 19;1864(10):1554-1565. doi: 10.1016/j.bbamcr.2017.06.011. PubMed
The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis. Brandimarti R, Hill GS, Geiger JD, Meucci O. Sci Rep. 2017 Nov 8;7(1):15103. doi: 10.1038/s41598-017-15128-8. PubMed
Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. Velagapudi R, El-Bakoush A, Olajide OA. Mol Neurobiol. 2018 Oct;55(10):8103-8123. doi: 10.1007/s12035-018-0975-2. Epub 2018 Mar 5. PubMed
Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells. Velagapudi R, Ajileye OO, Okorji U, Jain P, Aderogba MA, Olajide OA. Phytother Res. 2018 Oct;32(10):1957-1966. doi: 10.1002/ptr.6122. Epub 2018 May 22. PubMed
The core sequence of PIF competes for insulin/amyloid beta in insulin degrading enzyme: potential treatment for Alzheimer's disease. Hayrabedyan S, Todorova K, Spinelli M, Barnea ER, Mueller M. Oncotarget. 2018 Sep 21;9(74):33884-33895. doi: 10.18632/oncotarget.26057. eCollection 2018 Sep 21. PubMed
Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Dinamarca MC, Raveh A, Schneider A, Fritzius T, Fruh S, Rem PD, Stawarski M, Lalanne T, Turecek R, Choo M, Besseyrias V, Bildl W, Bentrop D, Staufenbiel M, Gassmann M, Fakler B, Schwenk J, Bettler B. Nat Commun. 2019 Mar 22;10(1):1331. doi: 10.1038/s41467-019-09164-3. PubMed
Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG Jr. BMC Mol Cell Biol. 2020 Jul 30;21(1):58. doi: 10.1186/s12860-020-00302-0. PubMed
Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer's Disease Patients. Iannuzzi F, Sirabella R, Canu N, Maier TJ, Annunziato L, Matrone C. Cells. 2020 Jul 30;9(8). pii: cells9081807. doi: 10.3390/cells9081807. PubMed
The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking. Montesinos J, Pera M, Larrea D, Guardia-Laguarta C, Agrawal RR, Velasco KR, Yun TD, Stavrovskaya IG, Xu Y, Koo SY, Snead AM, Sproul AA, Area-Gomez E. EMBO J. 2020 Oct 15;39(20):e103791. doi: 10.15252/embj.2019103791. Epub 2020 Aug 31. PubMed
Mitochondrial Membrane Potential Influences Amyloid-beta Protein Precursor Localization and Amyloid-beta Secretion. Wilkins HM, Troutwine BR, Menta BW, Manley SJ, Strope TA, Lysaker CR, Swerdlow RH. J Alzheimers Dis. 2022;85(1):381-394. doi: 10.3233/JAD-215280. PubMed
EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-beta Production. Nowakowska-Golacka J, Czapiewska J, Sominka H, Sowa-Rogozinska N, Slominska-Wojewodzka M. Int J Mol Sci. 2021 Dec 23;23(1). pii: ijms23010117. doi: 10.3390/ijms23010117. PubMed
Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model. Reinitz F, Chen EY, Nicolis di Robilant B, Chuluun B, Antony J, Jones RC, Gubbi N, Lee K, Ho WHD, Kolluru SS, Qian D, Adorno M, Piltti K, Anderson A, Monje M, Heller HC, Quake SR, Clarke MF. Elife. 2022 Mar 21;11:e66037. doi: 10.7554/eLife.66037. PubMed
The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities. Brandimarti R, Irollo E, Meucci O. Mol Neurobiol. 2023 Apr;60(4):1811-1825. doi: 10.1007/s12035-022-03153-2. Epub 2022 Dec 28. PubMed

If you have published an article using this material, please email us at [email protected] to have your article added to this page.