pLKO-puro FLAG SREBP2 Citations (11)
Originally described in: mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway.Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM Cell. 2011 Aug 5;146(3):408-20. PubMed Journal
Articles Citing pLKO-puro FLAG SREBP2
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| Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD. Oncogene. 2015 Jun 1. doi: 10.1038/onc.2015.179. PubMed |
Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.
Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B.
Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5197-E5206. doi: 10.1073/pnas.1705312114. Epub 2017 Jun 12.
PubMed
Associated Plasmids |
| High glucose induces the apoptosis of HUVECs in mitochondria dependent manner by enhancing VDAC1 expression. Zhang J, Guo Y, Ge W, Zhou X, Pan M. Pharmazie. 2018 Dec 1;73(12):725-728. doi: 10.1691/ph.2018.8544. PubMed |
Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP.
Romani P, Brian I, Santinon G, Pocaterra A, Audano M, Pedretti S, Mathieu S, Forcato M, Bicciato S, Manneville JB, Mitro N, Dupont S.
Nat Cell Biol. 2019 Mar;21(3):338-347. doi: 10.1038/s41556-018-0270-5. Epub 2019 Feb 4.
PubMed
Associated Plasmids |
| Cholesterol Pathway Inhibition Induces TGF-beta Signaling to Promote Basal Differentiation in Pancreatic Cancer. Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. Cancer Cell. 2020 Oct 12;38(4):567-583.e11. doi: 10.1016/j.ccell.2020.08.015. Epub 2020 Sep 24. PubMed |
| Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, Zeng A, Wang S, Zhou X, Li H, Zhang Q, Mo Q, Long J, Lan F, Chen Y, Hu J. Nat Commun. 2021 May 21;12(1):3005. doi: 10.1038/s41467-021-22782-0. PubMed |
| Postnatal eye size in mice is controlled by SREBP2-mediated transcriptional repression of Lrp2 and Bmp2. Mai S, Zhu X, Wan EYC, Wu S, Yonathan JN, Wang J, Li Y, Ma JYW, Zuo B, Tse DY, Lo PC, Wang X, Chan KM, Wu DM, Xiong W. Development. 2022 Jul 15;149(14):dev200633. doi: 10.1242/dev.200633. Epub 2022 Jul 14. PubMed |
| Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease. Tang W, Thundyil J, Lim GGY, Tng TJW, Yeow SQZ, Nair A, Chai C, Yao TP, Lim KL. Hum Mol Genet. 2023 Apr 20;32(9):1466-1482. doi: 10.1093/hmg/ddac297. PubMed |
| RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence. Hunt BG, Davis JC, Fox LH, Vicente-Munoz S, Lester C, Wells SI, Waltz SE. Oncogene. 2023 May;42(21):1716-1727. doi: 10.1038/s41388-023-02688-5. Epub 2023 Apr 7. PubMed |
| DAXX drives de novo lipogenesis and contributes to tumorigenesis. Mahmud I, Tian G, Wang J, Hutchinson TE, Kim BJ, Awasthee N, Hale S, Meng C, Moore A, Zhao L, Lewis JE, Waddell A, Wu S, Steger JM, Lydon ML, Chait A, Zhao LY, Ding H, Li JL, Purayil HT, Huo Z, Daaka Y, Garrett TJ, Liao D. Nat Commun. 2023 Apr 12;14(1):1927. doi: 10.1038/s41467-023-37501-0. PubMed |
| Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection. Firpo MR, LoMascolo NJ, Petit MJ, Shah PS, Mounce BC. PLoS Pathog. 2023 Apr 18;19(4):e1011317. doi: 10.1371/journal.ppat.1011317. eCollection 2023 Apr. PubMed |
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