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3xAP1pGL3 (3xAP-1 in pGL3-basic) Citations (43)

Originally described in: Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene.
Vasanwala FH, Kusam S, Toney LM, Dent AL J Immunol. 2002 Aug 15;169(4):1922-9.

Articles Citing 3xAP1pGL3 (3xAP-1 in pGL3-basic)

The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-beta that activates profibrogenic genes in hepatic stellate cells. Patel P, Khan N, Rani M, Gupta D, Jameel S. PLoS One. 2014 Feb 13;9(2):e88934. doi: 10.1371/journal.pone.0088934. eCollection 2014. PubMed
Engagement of Fas on Macrophages Modulates Poly I:C induced cytokine production with specific enhancement of IP-10. Lyons C, Fernandes P, Fanning LJ, Houston A, Brint E. PLoS One. 2015 Apr 7;10(4):e0123635. doi: 10.1371/journal.pone.0123635. eCollection 2015. PubMed
Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells. Muthukrishnan SD, Yang X, Friesel R, Oxburgh L. Nat Commun. 2015 Dec 4;6:10027. doi: 10.1038/ncomms10027. PubMed
MiR-196b is epigenetically silenced during the pre-malignant stage of lung carcinogenesis. Tellez CS, Juri DE, Do KC, Picchi MA, Wang T, Liu G, Spira AE, Belinsky SA. Cancer Res. 2016 Jun 14. pii: canres.3367.2015. PubMed
Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells. McCarthy CE, Duffney PF, Gelein R, Thatcher TH, Elder A, Phipps RP, Sime PJ. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1222-L1233. doi: 10.1152/ajplung.00183.2016. Epub 2016 Nov 11. PubMed
The cytoplasmic domain of MT1-MMP is dispensable for migration augmentation but necessary to mediate viability of MCF-7 breast cancer cells. Cepeda MA, Pelling JJ, Evered CL, Leong HS, Damjanovski S. Exp Cell Res. 2017 Jan 1;350(1):169-183. doi: 10.1016/j.yexcr.2016.11.019. Epub 2016 Nov 23. PubMed
The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment. Fan F, Bashari MH, Morelli E, Tonon G, Malvestiti S, Vallet S, Jarahian M, Seckinger A, Hose D, Bakiri L, Sun C, Hu Y, Ball CR, Glimm H, Sattler M, Goldschmidt H, Wagner EF, Tassone P, Jaeger D, Podar K. Leukemia. 2016 Dec 16. doi: 10.1038/leu.2016.358. PubMed
Inhibition of MT1-MMP proteolytic function and ERK1/2 signalling influences cell migration and invasion through changes in MMP-2 and MMP-9 levels. Cepeda MA, Evered CL, Pelling JJ, Damjanovski S. J Cell Commun Signal. 2017 Jan 9. doi: 10.1007/s12079-016-0373-3. PubMed
A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma. Guo G, Gong K, Ali S, Ali N, Shallwani S, Hatanpaa KJ, Pan E, Mickey B, Burma S, Wang DH, Kesari S, Sarkaria JN, Zhao D, Habib AA. Nat Neurosci. 2017 Aug;20(8):1074-1084. doi: 10.1038/nn.4584. Epub 2017 Jun 12. PubMed
Stable expression of alpha1-antitrypsin Portland in MDA-MB-231 cells increased MT1-MMP and MMP-9 levels, but reduced tumour progression. Willson JA, Muir CA, Evered CL, Cepeda MA, Damjanovski S. J Cell Commun Signal. 2018 Jun;12(2):479-488. doi: 10.1007/s12079-017-0407-5. Epub 2017 Aug 29. PubMed
The IKK/NF-kappaB signaling pathway requires Morgana to drive breast cancer metastasis. Fusella F, Secli L, Busso E, Krepelova A, Moiso E, Rocca S, Conti L, Annaratone L, Rubinetto C, Mello-Grand M, Singh V, Chiorino G, Silengo L, Altruda F, Turco E, Morotti A, Oliviero S, Castellano I, Cavallo F, Provero P, Tarone G, Brancaccio M. Nat Commun. 2017 Nov 21;8(1):1636. doi: 10.1038/s41467-017-01829-1. PubMed
Fluid shear stress regulates the expression of Lectin-like oxidized low density lipoprotein receptor-1 via KLF2-AP-1 pathway depending on its intensity and pattern in endothelial cells. Lee JY, Chung J, Kim KH, An SH, Kim M, Park J, Kwon K. Atherosclerosis. 2018 Mar;270:76-88. doi: 10.1016/j.atherosclerosis.2018.01.038. Epub 2018 Jan 31. PubMed
Overexpression of Protein Kinase Inhibitor Alpha Reverses Rat Low Voluntary Running Behavior. Grigsby KB, Ruegsegger GN, Childs TE, Booth FW. Mol Neurobiol. 2019 Mar;56(3):1782-1797. doi: 10.1007/s12035-018-1171-0. Epub 2018 Jun 21. PubMed
Characterization of the effects of immunomodulatory drug fingolimod (FTY720) on human T cell receptor signaling pathways. Baer A, Colon-Moran W, Bhattarai N. Sci Rep. 2018 Jul 19;8(1):10910. doi: 10.1038/s41598-018-29355-0. PubMed
The DNMT1-associated lincRNA DACOR1 reprograms genome-wide DNA methylation in colon cancer. Somasundaram S, Forrest ME, Moinova H, Cohen A, Varadan V, LaFramboise T, Markowitz S, Khalil AM. Clin Epigenetics. 2018 Oct 22;10(1):127. doi: 10.1186/s13148-018-0555-3. PubMed
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ. Cell Rep. 2018 Nov 20;25(8):2148-2162.e5. doi: 10.1016/j.celrep.2018.10.074. PubMed
Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer. Hosford SR, Shee K, Wells JD, Traphagen NA, Fields JL, Hampsch RA, Kettenbach AN, Demidenko E, Miller TW. Mol Oncol. 2019 Aug;13(8):1778-1794. doi: 10.1002/1878-0261.12528. Epub 2019 Jul 9. PubMed
Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins. Jameson NM, Ma J, Benitez J, Izurieta A, Han JY, Mendez R, Parisian A, Furnari F. Mol Cancer Res. 2019 Nov;17(11):2208-2220. doi: 10.1158/1541-7786.MCR-19-0747. Epub 2019 Aug 23. PubMed
Coxsackievirus and adenovirus receptor mediates the responses of endothelial cells to fluid shear stress. Chung J, Kim KH, An SH, Lee S, Lim BK, Kang SW, Kwon K. Exp Mol Med. 2019 Nov 27;51(11):144. doi: 10.1038/s12276-019-0347-7. PubMed
YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression. Li H, Li Q, Dang K, Ma S, Cotton JL, Yang S, Zhu LJ, Deng AC, Ip YT, Johnson RL, Wu X, Punzo C, Mao J. Cell Rep. 2019 Dec 3;29(10):3200-3211.e4. doi: 10.1016/j.celrep.2019.03.021. PubMed
Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest. Ye L, Zhang J, Zhang Y, Gu B, Zhu H, Mao X. Biomed Res Int. 2020 Mar 8;2020:9259852. doi: 10.1155/2020/9259852. eCollection 2020. PubMed
Inhibition of ERKs/Akt-Mediated c-Fos Expression Is Required for Piperlongumine-Induced Cyclin D1 Downregulation and Tumor Suppression in Colorectal Cancer Cells. Gao F, Zhou L, Li M, Liu W, Yang S, Li W. Onco Targets Ther. 2020 Jun 15;13:5591-5603. doi: 10.2147/OTT.S251295. eCollection 2020. PubMed
Functional characterization of myeloid differentiation factor 88 in Nile tilapia (Oreochromis niloticus). Trung NB, Lee PT. Comp Biochem Physiol B Biochem Mol Biol. 2020 Dec;250:110485. doi: 10.1016/j.cbpb.2020.110485. Epub 2020 Aug 6. PubMed
Xanthohumol targets the ERK1/2Fra1 signaling axis to reduce cyclin D1 expression and inhibit nonsmall cell lung cancer. Gao F, Li M, Zhou L, Liu W, Zuo H, Li W. Oncol Rep. 2020 Oct;44(4):1365-1374. doi: 10.3892/or.2020.7697. Epub 2020 Jul 20. PubMed
The dipeptidyl peptidase (DPP)-4 inhibitor trelagliptin inhibits IL-1beta-induced endothelial inflammation and monocytes attachment. Meng J, Zhang W, Wang C, Xiong S, Wang Q, Li H, Liu G, Hao Z. Int Immunopharmacol. 2020 Dec;89(Pt B):106996. doi: 10.1016/j.intimp.2020.106996. Epub 2020 Oct 10. PubMed
A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5alpha. Saha B, Chisholm D, Kell AM, Mandell MA. PLoS Pathog. 2020 Oct 14;16(10):e1009017. doi: 10.1371/journal.ppat.1009017. eCollection 2020 Oct. PubMed
Anti-cancer potential of persimmon (Diospyros kaki) leaves via the PDGFR-Rac-JNK pathway. Kim HS, Suh JS, Jang YK, Ahn SH, Raja G, Kim JC, Jung Y, Jung SH, Kim TJ. Sci Rep. 2020 Oct 22;10(1):18119. doi: 10.1038/s41598-020-75140-3. PubMed
Expression, signal transduction, and function analysis of TIRAP and TRIF in Nile tilapia (Oreochromis niloticus). Trung NB, Nan FH, Wang IJ, Wu YC, Wen CM, Lee MC, Hang HT, Lee PT. Dev Comp Immunol. 2021 Apr;117:103991. doi: 10.1016/j.dci.2020.103991. Epub 2020 Dec 30. PubMed
Data-Driven Computational Modeling Identifies Determinants of Glioblastoma Response to SHP2 Inhibition. Day EK, Zhong Q, Purow B, Lazzara MJ. Cancer Res. 2021 Apr 15;81(8):2056-2070. doi: 10.1158/0008-5472.CAN-20-1756. Epub 2021 Feb 11. PubMed
HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers. Di Giorgio E, Paluvai H, Dalla E, Ranzino L, Renzini A, Moresi V, Minisini M, Picco R, Brancolini C. Genome Biol. 2021 May 10;22(1):129. doi: 10.1186/s13059-021-02340-z. PubMed
MicroRNA218 inhibits the malignant phenotypes of glioma by modulating the TNC/AKT/AP1/TGFbeta1 feedback signaling loop. Dang S, Zhang R, Tian S, Hou P, Li G, Ji M. Int J Mol Med. 2021 Nov;48(5). pii: 205. doi: 10.3892/ijmm.2021.5038. Epub 2021 Sep 24. PubMed
SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells. Gopalakrishnan S, Uma SK, Mohan G, Mohan A, Shanmugam G, Kumar VTV, J S, Chandrika SK, Vasudevan D, Nori SRC, Sathi SN, George S, Maliekal TT. Front Immunol. 2021 Nov 19;12:740620. doi: 10.3389/fimmu.2021.740620. eCollection 2021. PubMed
Transglutaminase 2 mediates UVB-induced matrix metalloproteinase-1 expression by inhibiting nuclear p65 degradation in dermal fibroblasts. Lee SJ, Lee KB, Hong AY, Son YH, Lee DH, Jeong EM, Kim IG. Exp Dermatol. 2021 Dec 9. doi: 10.1111/exd.14512. PubMed
Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. Nataraj NB, Noronha A, Lee JS, Ghosh S, Mohan Raju HR, Sekar A, Zuckerman B, Lindzen M, Tarcitano E, Srivastava S, Selitrennik M, Livneh I, Drago-Garcia D, Rueda O, Caldas C, Lev S, Geiger T, Ciechanover A, Ulitsky I, Seger R, Ruppin E, Yarden Y. Cell Rep. 2022 Feb 22;38(8):110418. doi: 10.1016/j.celrep.2022.110418. PubMed
ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis. Ramirez NP, Lee J, Zheng Y, Li L, Dennis B, Chen D, Challa A, Planelles V, Westover KD, Alto NM, D'Orso I. Nat Commun. 2022 Mar 1;13(1):1109. doi: 10.1038/s41467-022-28772-0. PubMed
Double-Stranded RNA Enhances Matrix Metalloproteinase-1 and -13 Expressions through TLR3-Dependent Activation of Transglutaminase 2 in Dermal Fibroblasts. Hong AY, Lee SJ, Lee KB, Shin JW, Jeong EM, Kim IG. Int J Mol Sci. 2022 Feb 28;23(5). pii: ijms23052709. doi: 10.3390/ijms23052709. PubMed
Label-Free Target Identification Reveals the Anticancer Mechanism of a Rhenium Isonitrile Complex. Yim J, Park SB. Front Chem. 2022 Mar 14;10:850638. doi: 10.3389/fchem.2022.850638. eCollection 2022. PubMed
Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5alpha in mitophagy. Saha B, Salemi M, Williams GL, Oh S, Paffett ML, Phinney B, Mandell MA. Cell Rep. 2022 May 10;39(6):110797. doi: 10.1016/j.celrep.2022.110797. PubMed
Bis-Cinnamamide Derivatives as APE/Ref-1 Inhibitors for the Treatment of Human Melanoma. Alhazmi R, Tong S, Darwish S, Khanjani E, Khungar B, Chawla S, Zheng Z, Chamberlin R, Parang K, Yang S. Molecules. 2022 Apr 21;27(9). pii: molecules27092672. doi: 10.3390/molecules27092672. PubMed
Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis. Al Moussawi K, Chung K, Carroll TM, Osterburg C, Smirnov A, Lotz R, Miller P, Dedeic Z, Zhong S, Oti M, Kouwenhoven EN, Asher R, Goldin R, Tellier M, Murphy S, Zhou H, Dotsch V, Lu X. Cell Rep. 2022 Oct 18;41(3):111503. doi: 10.1016/j.celrep.2022.111503. PubMed
NQO1 regulates cell cycle progression at the G2/M phase. Oh ET, Kim HG, Kim CH, Lee J, Kim C, Lee JS, Cho Y, Park HJ. Theranostics. 2023 Jan 10;13(3):873-895. doi: 10.7150/thno.77444. eCollection 2023. PubMed
Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation. Liu LL, Han Y, Zhang ZJ, Wang YQ, Hu YW, Kaznacheyeva E, Ding JQ, Guo DK, Wang GH, Li B, Ren HG. Acta Pharmacol Sin. 2023 May 25. doi: 10.1038/s41401-023-01104-8. PubMed
A microRNA Arising from the Negative Strand of SARS-CoV-2 Genome Targets FOS to Reduce AP-1 Activity. Greco F, Lorefice E, Carissimi C, Laudadio I, Ciccosanti F, Di Rienzo M, Colavita F, Meschi S, Maggi F, Fimia GM, Fulci V. Noncoding RNA. 2023 May 23;9(3):33. doi: 10.3390/ncrna9030033. PubMed

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