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pHM6-alphasynuclein-WT Citations (10)

Originally described in: Alpha-synuclein overexpression promotes aggregation of mutant huntingtin.
Furlong RA, Narain Y, Rankin J, Wyttenbach A, Rubinsztein DC Biochem J. 2000 Mar 15;346 Pt 3:577-81.
PubMed Journal

Articles Citing pHM6-alphasynuclein-WT

Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. Jorge-Finnigan A, Kleppe R, Jung-Kc K, Ying M, Marie M, Rios-Mondragon I, Salvatore MF, Saraste J, Martinez A. J Biol Chem. 2017 Jun 21. pii: jbc.M116.762344. doi: 10.1074/jbc.M116.762344. PubMed
Accumulation of autophagosomes confers cytotoxicity. Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S. J Biol Chem. 2017 Jul 3. pii: jbc.M117.782276. doi: 10.1074/jbc.M117.782276. PubMed
Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models. Shaltouki A, Hsieh CH, Kim MJ, Wang X. Acta Neuropathol. 2018 Oct;136(4):607-620. doi: 10.1007/s00401-018-1873-4. Epub 2018 Jun 9. PubMed
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity. Jan A, Jansonius B, Delaidelli A, Bhanshali F, An YA, Ferreira N, Smits LM, Negri GL, Schwamborn JC, Jensen PH, Mackenzie IR, Taubert S, Sorensen PH. Acta Neuropathol Commun. 2018 Jul 2;6(1):54. doi: 10.1186/s40478-018-0554-9. PubMed
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of alpha-synuclein. Harischandra DS, Rokad D, Neal ML, Ghaisas S, Manne S, Sarkar S, Panicker N, Zenitsky G, Jin H, Lewis M, Huang X, Anantharam V, Kanthasamy A, Kanthasamy AG. Sci Signal. 2019 Mar 12;12(572). pii: 12/572/eaau4543. doi: 10.1126/scisignal.aau4543. PubMed
Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade. Hatstat AK, Ahrendt HD, Foster MW, Mayne L, Moseley MA, Englander SW, McCafferty DG. Cell Chem Biol. 2021 Jan 21;28(1):14-25.e9. doi: 10.1016/j.chembiol.2020.10.008. Epub 2020 Nov 10. PubMed
alpha-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response. Delaidelli A, Richner M, Jiang L, van der Laan A, Bergholdt Jul Christiansen I, Ferreira N, Nyengaard JR, Vaegter CB, Jensen PH, Mackenzie IR, Sorensen PH, Jan A. Acta Neuropathol Commun. 2021 Jun 6;9(1):105. doi: 10.1186/s40478-021-01209-3. PubMed
Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration. Wang C, Lau CY, Ma F, Zheng C. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34). pii: 2106504118. doi: 10.1073/pnas.2106504118. PubMed
Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against alpha-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells. McCarthy E, Barron A, Morales-Prieto N, Mazzocchi M, McCarthy CM, Collins LM, Sullivan AM, O'Keeffe GW. Mol Neurobiol. 2022 May;59(5):2745-2757. doi: 10.1007/s12035-022-02768-9. Epub 2022 Feb 17. PubMed
Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Kim MS, Ra EA, Kweon SH, Seo BA, Ko HS, Oh Y, Lee G. Cell Stem Cell. 2023 Jul 6;30(7):973-986.e11. doi: 10.1016/j.stem.2023.05.015. Epub 2023 Jun 19. PubMed

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