pLHCX-FLAG-mPKM2 Citations (5)

Originally described in: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC Nature. 2008 Mar 13;452(7184):230-3. doi: 10.1038/nature06734. PubMed Journal

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Articles Citing pLHCX-FLAG-mPKM2

Articles
PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N. Cancer Cell. 2018 Mar 12;33(3):355-367.e7. doi: 10.1016/j.ccell.2018.02.004. PubMed
Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy. Fu J, Shinjo T, Li Q, St-Louis R, Park K, Yu MG, Yokomizo H, Simao F, Huang Q, Wu IH, King GL. JCI Insight. 2022 Mar 8;7(5):e155260. doi: 10.1172/jci.insight.155260. PubMed
Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation. Veras FP, Publio GA, Melo BM, Prado DS, Norbiato T, Cecilio NT, Hiroki C, Damasceno LEA, Jung R, Toller-Kawahisa JE, Martins TV, Assuncao SF, Lima D, Alves MG, Vieira GV, Tavares LA, Alves-Rezende ALR, Karbach SH, Nakaya HI, Cunha TM, Souza CS, Cunha FQ, Sales KU, Waisman A, Alves-Filho JC. Cell Rep. 2022 Dec 27;41(13):111897. doi: 10.1016/j.celrep.2022.111897. PubMed
CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity. Holling GA, Chavel CA, Sharda AP, Lieberman MM, James CM, Lightman SM, Tong JH, Qiao G, Emmons TR, Giridharan T, Hou S, Intlekofer AM, Higashi RM, Fan TWM, Lane AN, Eng KH, Segal BH, Repasky EA, Lee KP, Olejniczak SH. Cell Mol Immunol. 2024 Mar;21(3):260-274. doi: 10.1038/s41423-024-01124-2. Epub 2024 Jan 18. PubMed
HIF2alpha inhibits glutaminase clustering in mitochondria to sustain growth of clear cell renal cell carcinoma. Zhao W, Demczyszyn SM, Coffey NJ, Jiang Y, Kim B, Bowers S, Bowman C, Noji MC, Jang C, Simon MC, Arany Z, Kim B. JCI Insight. 2025 Oct 30;10(23):e182711. doi: 10.1172/jci.insight.182711. eCollection 2025 Dec 8. PubMed

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