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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC Nature. 2008 Mar 13;452(7184):230-3. doi: 10.1038/nature06734.