Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected]. Learn more


pcDNA5/FRT-HA-hM3D(Gq) Citations (10)

Originally described in: Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.
Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8. Epub 2007 Mar 2.
PubMed Journal

Articles Citing pcDNA5/FRT-HA-hM3D(Gq)

Activation of transient receptor potential vanilloid 1 by lipoxygenase metabolites depends on PKC phosphorylation. Kumar R, Hazan A, Geron M, Steinberg R, Livni L, Matzner H, Priel A. FASEB J. 2016 Dec 16. pii: fj.201601132R. PubMed
Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior. Bocchi R, Egervari K, Carol-Perdiguer L, Viale B, Quairiaux C, De Roo M, Boitard M, Oskouie S, Salmon P, Kiss JZ. Nat Commun. 2017 Oct 27;8(1):1158. doi: 10.1038/s41467-017-01046-w. PubMed

Associated Plasmids

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner. Mitew S, Gobius I, Fenlon LR, McDougall SJ, Hawkes D, Xing YL, Bujalka H, Gundlach AL, Richards LJ, Kilpatrick TJ, Merson TD, Emery B. Nat Commun. 2018 Jan 22;9(1):306. doi: 10.1038/s41467-017-02719-2. PubMed
Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex. Vitali I, Fievre S, Telley L, Oberst P, Bariselli S, Frangeul L, Baumann N, McMahon JJ, Klingler E, Bocchi R, Kiss JZ, Bellone C, Silver DL, Jabaudon D. Cell. 2018 Aug 23;174(5):1264-1276.e15. doi: 10.1016/j.cell.2018.06.036. Epub 2018 Jul 26. PubMed
Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits. Zhou QG, Nemes AD, Lee D, Ro EJ, Zhang J, Nowacki AS, Dymecki SM, Najm IM, Suh H. J Clin Invest. 2019 Jan 2;129(1):310-323. doi: 10.1172/JCI95731. Epub 2018 Dec 3. PubMed
DREADD-based synthetic control of chondrocyte calcium signaling in vitro. McDonough RC, Shoga JS, Price C. J Orthop Res. 2019 Jul;37(7):1518-1529. doi: 10.1002/jor.24285. Epub 2019 Mar 28. PubMed
GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception. Cohen E, Kumar R, Zinger T, Priel A, Treinin M. Front Pharmacol. 2020 Jan 17;10:1567. doi: 10.3389/fphar.2019.01567. eCollection 2019. PubMed
Monitoring TRPC7 Conformational Changes by BRET Following GPCR Activation. Petigny C, Dumont AA, Giguere H, Collette A, Holleran BJ, Iftinca M, Altier C, Besserer-Offroy E, Auger-Messier M, Leduc R. Int J Mol Sci. 2022 Feb 24;23(5). pii: ijms23052502. doi: 10.3390/ijms23052502. PubMed
Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch. Kanehisa K, Koga K, Maejima S, Shiraishi Y, Asai K, Shiratori-Hayashi M, Xiao MF, Sakamoto H, Worley PF, Tsuda M. Nat Commun. 2022 May 2;13(1):2367. doi: 10.1038/s41467-022-30089-x. PubMed
Two-step structural changes in M3 muscarinic receptor activation rely on the coupled G(q) protein cycle. Kim YS, Yeon JH, Ko W, Suh BC. Nat Commun. 2023 Mar 8;14(1):1276. doi: 10.1038/s41467-023-36911-4. PubMed

If you have published an article using this material, please email us at [email protected] to have your article added to this page.