pTet-O-Ngn2-puro Citations (81)
Originally described in: Rapid single-step induction of functional neurons from human pluripotent stem cells.Zhang Y, Pak C, Han Y, Ahlenius H, Zhang Z, Chanda S, Marro S, Patzke C, Acuna C, Covy J, Xu W, Yang N, Danko T, Chen L, Wernig M, Sudhof TC Neuron. 2013 Jun 5;78(5):785-98. doi: 10.1016/j.neuron.2013.05.029. PubMed Journal
Articles Citing pTet-O-Ngn2-puro
| Articles |
|---|
Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells.
Ho SM, Hartley BJ, Tcw J, Beaumont M, Stafford K, Slesinger PA, Brennand KJ.
Methods. 2015 Nov 25. pii: S1046-2023(15)30159-6. doi: 10.1016/j.ymeth.2015.11.019.
PubMed
Associated Plasmids |
| Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models. Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Muller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ. Mol Psychiatry. 2016 Oct 18. doi: 10.1038/mp.2016.163. PubMed |
| Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ. Curr Protoc Hum Genet. 2017 Jan 11;92:21.8.1-21.8.21. doi: 10.1002/cphg.33. PubMed |
| Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7. doi: 10.1016/j.stem.2016.11.018. Epub 2017 Jan 12. PubMed |
| Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. Aneichyk T, Hendriks WT, Yadav R, Shin D, Gao D, Vaine CA, Collins RL, Domingo A, Currall B, Stortchevoi A, Multhaupt-Buell T, Penney EB, Cruz L, Dhakal J, Brand H, Hanscom C, Antolik C, Dy M, Ragavendran A, Underwood J, Cantsilieris S, Munson KM, Eichler EE, Acuna P, Go C, Jamora RDG, Rosales RL, Church DM, Williams SR, Garcia S, Klein C, Muller U, Wilhelmsen KC, Timmers HTM, Sapir Y, Wainger BJ, Henderson D, Ito N, Weisenfeld N, Jaffe D, Sharma N, Breakefield XO, Ozelius LJ, Bragg DC, Talkowski ME. Cell. 2018 Feb 22;172(5):897-909.e21. doi: 10.1016/j.cell.2018.02.011. PubMed |
| Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JW. Mol Cell. 2018 Apr 19;70(2):211-227.e8. doi: 10.1016/j.molcel.2018.03.012. Epub 2018 Apr 12. PubMed |
| Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Srikanth P, Lagomarsino VN, Pearse RV 2nd, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL. Transl Psychiatry. 2018 Nov 8;8(1):245. doi: 10.1038/s41398-018-0281-9. PubMed |
| Lipidomic Analysis of alpha-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. PubMed |
| A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons. Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP. Sci Rep. 2019 Jun 21;9(1):9000. doi: 10.1038/s41598-019-45265-1. PubMed |
| Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Patzke C, Brockmann MM, Dai J, Gan KJ, Grauel MK, Fenske P, Liu Y, Acuna C, Rosenmund C, Sudhof TC. Cell. 2019 Oct 3;179(2):498-513.e22. doi: 10.1016/j.cell.2019.09.011. PubMed |
| Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons. Winden KD, Sundberg M, Yang C, Wafa SMA, Dwyer S, Chen PF, Buttermore ED, Sahin M. J Neurosci. 2019 Nov 20;39(47):9294-9305. doi: 10.1523/JNEUROSCI.0642-19.2019. Epub 2019 Oct 7. PubMed |
| GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease. Ko HJ, Chiou SJ, Wong YH, Wang YH, Lai Y, Chou CH, Wang C, Loh JK, Lieu AS, Cheng JT, Lin YT, Lu PJ, Fann MJ, Huang CF, Hong YR. J Clin Med. 2019 Oct 21;8(10). pii: jcm8101751. doi: 10.3390/jcm8101751. PubMed |
| Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer's disease using patient iPSC-derived neurons. Wu PC, Fann MJ, Tran TT, Chen SC, Devina T, Cheng IH, Lien CC, Kao LS, Wang SJ, Fuh JL, Tzeng TT, Huang CY, Shiao YJ, Wong YH. Sci Rep. 2019 Dec 17;9(1):19301. doi: 10.1038/s41598-019-55614-9. PubMed |
| Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons. Whipple AJ, Breton-Provencher V, Jacobs HN, Chitta UK, Sur M, Sharp PA. Mol Cell. 2020 Apr 2;78(1):85-95.e8. doi: 10.1016/j.molcel.2020.01.020. Epub 2020 Feb 6. PubMed |
| Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells. Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M. Stem Cell Res. 2020 Oct;48:101945. doi: 10.1016/j.scr.2020.101945. Epub 2020 Aug 3. PubMed |
| Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens. Black JB, McCutcheon SR, Dube S, Barrera A, Klann TS, Rice GA, Adkar SS, Soderling SH, Reddy TE, Gersbach CA. Cell Rep. 2020 Dec 1;33(9):108460. doi: 10.1016/j.celrep.2020.108460. PubMed |
| Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia. Ryan SK, Jordan-Sciutto KL, Anderson SA. STAR Protoc. 2020 Dec 1;1(3):100190. doi: 10.1016/j.xpro.2020.100190. eCollection 2020 Dec 18. PubMed |
Dyshomeostatic modulation of Ca(2+)-activated K(+) channels in a human neuronal model of KCNQ2 encephalopathy.
Simkin D, Marshall KA, Vanoye CG, Desai RR, Bustos BI, Piyevsky BN, Ortega JA, Forrest M, Robertson GL, Penzes P, Laux LC, Lubbe SJ, Millichap JJ, George AL Jr, Kiskinis E.
Elife. 2021 Feb 5;10. pii: 64434. doi: 10.7554/eLife.64434.
PubMed
Associated Plasmids |
| H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model. Haag D, Mack N, Benites Goncalves da Silva P, Statz B, Clark J, Tanabe K, Sharma T, Jager N, Jones DTW, Kawauchi D, Wernig M, Pfister SM. Cancer Cell. 2021 Mar 8;39(3):407-422.e13. doi: 10.1016/j.ccell.2021.01.005. Epub 2021 Feb 4. PubMed |
| NGN2 mmRNA-Based Transcriptional Programming in Microfluidic Guides hiPSCs Toward Neural Fate With Multiple Identities. Tolomeo AM, Laterza C, Grespan E, Michielin F, Canals I, Kokaia Z, Muraca M, Gagliano O, Elvassore N. Front Cell Neurosci. 2021 Feb 12;15:602888. doi: 10.3389/fncel.2021.602888. eCollection 2021. PubMed |
| Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs. Hasan MF, Berdichevsky Y. Commun Biol. 2021 May 17;4(1):587. doi: 10.1038/s42003-021-02104-2. PubMed |
| Human cell transformation by combined lineage conversion and oncogene expression. Sahu B, Pihlajamaa P, Zhang K, Palin K, Ahonen S, Cervera A, Ristimaki A, Aaltonen LA, Hautaniemi S, Taipale J. Oncogene. 2021 Sep;40(36):5533-5547. doi: 10.1038/s41388-021-01940-0. Epub 2021 Jul 23. PubMed |
| Direct Differentiation of Functional Neurons from Human Pluripotent Stem Cells (hPSCs). Hu R, Zhu X, Yang N. Methods Mol Biol. 2021;2352:117-126. doi: 10.1007/978-1-0716-1601-7_8. PubMed |
| Transcription Factor Programming of Human Pluripotent Stem Cells to Functionally Mature Astrocytes for Monocultures and Cocultures with Neurons. Quist E, Ahlenius H, Canals I. Methods Mol Biol. 2021;2352:133-148. doi: 10.1007/978-1-0716-1601-7_10. PubMed |
| Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Lagomarsino VN, Pearse RV 2nd, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, Fancher SB, He A, Merchant JP, Duong DM, Martinez H, Zhou M, Bah F, Vicent MA, Stricker JMS, Xu J, Dammer EB, Levey AI, Chibnik LB, Menon V, Seyfried NT, De Jager PL, Noggle S, Selkoe DJ, Bennett DA, Young-Pearse TL. Neuron. 2021 Nov 3;109(21):3402-3420.e9. doi: 10.1016/j.neuron.2021.08.003. Epub 2021 Sep 1. PubMed |
| A synaptic temperature sensor for body cooling. Kamm GB, Boffi JC, Zuza K, Nencini S, Campos J, Schrenk-Siemens K, Sonntag I, Kabaoglu B, El Hay MYA, Schwarz Y, Tappe-Theodor A, Bruns D, Acuna C, Kuner T, Siemens J. Neuron. 2021 Oct 20;109(20):3283-3297.e11. doi: 10.1016/j.neuron.2021.10.001. PubMed |
| VLDLR and ApoER2 are receptors for multiple alphaviruses. Clark LE, Clark SA, Lin C, Liu J, Coscia A, Nabel KG, Yang P, Neel DV, Lee H, Brusic V, Stryapunina I, Plante KS, Ahmed AA, Catteruccia F, Young-Pearse TL, Chiu IM, Llopis PM, Weaver SC, Abraham J. Nature. 2022 Feb;602(7897):475-480. doi: 10.1038/s41586-021-04326-0. Epub 2021 Dec 20. PubMed |
| APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons. Wu CI, Vinton EA, Pearse RV 2nd, Heo K, Aylward AJ, Hsieh YC, Bi Y, Adeleye S, Fancher S, Duong DM, Seyfried NT, Schwarz TL, Young-Pearse TL. Mol Psychiatry. 2022 Apr;27(4):1970-1989. doi: 10.1038/s41380-022-01454-5. Epub 2022 Feb 23. PubMed |
| Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium. Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Takemoto Y, Hatanaka F, Yoshida K, Prieto J, Sahu SK, Takahashi Y, Reddy P, O'Keefe DD, Rodriguez Esteban C, Knoepfler PS, Nunez Delicado E, Castells A, Campistol JM, Kato R, Nakagawa H, Izpisua Belmonte JC. Front Cell Dev Biol. 2022 Mar 4;10:786031. doi: 10.3389/fcell.2022.786031. eCollection 2022. PubMed |
| Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs. Sanchez-Priego C, Hu R, Boshans LL, Lalli M, Janas JA, Williams SE, Dong Z, Yang N. Cell Rep. 2022 May 31;39(9):110877. doi: 10.1016/j.celrep.2022.110877. PubMed |
| YAP inhibits ERalpha and ER(+) breast cancer growth by disrupting a TEAD-ERalpha signaling axis. Li X, Zhuo S, Zhuang T, Cho YS, Wu G, Liu Y, Mu K, Zhang K, Su P, Yang Y, Zhang CC, Zhu J, Jiang J. Nat Commun. 2022 Jun 2;13(1):3075. doi: 10.1038/s41467-022-30831-5. PubMed |
| Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, Caldwell KA, Selkoe D. NPJ Parkinsons Dis. 2022 Jun 9;8(1):74. doi: 10.1038/s41531-022-00335-6. PubMed |
| Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder. Lim ET, Chan Y, Dawes P, Guo X, Erdin S, Tai DJC, Liu S, Reichert JM, Burns MJ, Chan YK, Chiang JJ, Meyer K, Zhang X, Walsh CA, Yankner BA, Raychaudhuri S, Hirschhorn JN, Gusella JF, Talkowski ME, Church GM. Nat Commun. 2022 Jun 10;13(1):3243. doi: 10.1038/s41467-022-30968-3. PubMed |
| Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1. Mabe NW, Huang M, Dalton GN, Alexe G, Schaefer DA, Geraghty AC, Robichaud AL, Conway AS, Khalid D, Mader MM, Belk JA, Ross KN, Sheffer M, Linde MH, Ly N, Yao W, Rotiroti MC, Smith BAH, Wernig M, Bertozzi CR, Monje M, Mitsiades CS, Majeti R, Satpathy AT, Stegmaier K, Majzner RG. Nat Cancer. 2022 Aug;3(8):976-993. doi: 10.1038/s43018-022-00405-x. Epub 2022 Jul 11. PubMed |
Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming.
Bergmann T, Liu Y, Skov J, Mogus L, Lee J, Pfisterer U, Handfield LF, Asenjo-Martinez A, Lisa-Vargas I, Seemann SE, Lee JTH, Patikas N, Kornum BR, Denham M, Hyttel P, Witter MP, Gorodkin J, Pers TH, Hemberg M, Khodosevich K, Hall VJ.
Front Cell Dev Biol. 2022 Aug 15;10:976549. doi: 10.3389/fcell.2022.976549. eCollection 2022.
PubMed
Associated Plasmids |
| Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models. Susco SG, Ghosh S, Mazzucato P, Angelini G, Beccard A, Barrera V, Berryer MH, Messana A, Lam D, Hazelbaker DZ, Barrett LE. Cell Rep. 2022 Sep 6;40(10):111312. doi: 10.1016/j.celrep.2022.111312. PubMed |
| In vitro neurons learn and exhibit sentience when embodied in a simulated game-world. Kagan BJ, Kitchen AC, Tran NT, Habibollahi F, Khajehnejad M, Parker BJ, Bhat A, Rollo B, Razi A, Friston KJ. Neuron. 2022 Dec 7;110(23):3952-3969.e8. doi: 10.1016/j.neuron.2022.09.001. Epub 2022 Oct 12. PubMed |
| CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons. McSweeney D, Gabriel R, Jin K, Pang ZP, Aronow B, Pak C. iScience. 2022 Sep 23;25(10):105187. doi: 10.1016/j.isci.2022.105187. eCollection 2022 Oct 21. PubMed |
| Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation. Janas JA, Zhang L, Luu JH, Demeter J, Meng L, Marro SG, Mall M, Mooney NA, Schaukowitch K, Ng YH, Yang N, Huang Y, Neumayer G, Gozani O, Elias JE, Jackson PK, Wernig M. Mol Cell. 2022 Dec 15;82(24):4627-4646.e14. doi: 10.1016/j.molcel.2022.11.002. Epub 2022 Nov 22. PubMed |
| YAP antagonizes TEAD-mediated AR signaling and prostate cancer growth. Li X, Zhuo S, Cho YS, Liu Y, Yang Y, Zhu J, Jiang J. EMBO J. 2023 Feb 15;42(4):e112184. doi: 10.15252/embj.2022112184. Epub 2023 Jan 2. PubMed |
| Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons. Alvarez Z, Ortega JA, Sato K, Sasselli IR, Kolberg-Edelbrock AN, Qiu R, Marshall KA, Nguyen TP, Smith CS, Quinlan KA, Papakis V, Syrgiannis Z, Sather NA, Musumeci C, Engel E, Stupp SI, Kiskinis E. Cell Stem Cell. 2023 Feb 2;30(2):219-238.e14. doi: 10.1016/j.stem.2022.12.010. Epub 2023 Jan 12. PubMed |
| Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression. Savchuk S, Gentry K, Wang W, Carleton E, Yalcin B, Liu Y, Pavarino EC, LaBelle J, Toland AM, Woo PJ, Qu F, Filbin MG, Krasnow MA, Sabatini BL, Sage J, Monje M, Venkatesh HS. bioRxiv. 2023 Jan 20:2023.01.19.524430. doi: 10.1101/2023.01.19.524430. Preprint. PubMed |
| Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease. Merchant JP, Zhu K, Henrion MYR, Zaidi SSA, Lau B, Moein S, Alamprese ML, Pearse RV 2nd, Bennett DA, Ertekin-Taner N, Young-Pearse TL, Chang R. Commun Biol. 2023 May 15;6(1):503. doi: 10.1038/s42003-023-04791-5. PubMed |
| Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects. Ayers KL, Eggers S, Rollo BN, Smith KR, Davidson NM, Siddall NA, Zhao L, Bowles J, Weiss K, Zanni G, Burglen L, Ben-Shachar S, Rosensaft J, Raas-Rothschild A, Jorgensen A, Schittenhelm RB, Huang C, Robevska G, van den Bergen J, Casagranda F, Cyza J, Pachernegg S, Wright DK, Bahlo M, Oshlack A, O'Brien TJ, Kwan P, Koopman P, Hime GR, Girard N, Hoffmann C, Shilon Y, Zung A, Bertini E, Milh M, Ben Rhouma B, Belguith N, Bashamboo A, McElreavey K, Banne E, Weintrob N, BenZeev B, Sinclair AH. Nat Commun. 2023 Jun 9;14(1):3403. doi: 10.1038/s41467-023-39040-0. PubMed |
| High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia. Saffari A, Brechmann B, Boeger C, Saber WA, Jumo H, Whye D, Wood D, Wahlster L, Alecu J, Ziegler M, Scheffold M, Winden K, Hubbs J, Buttermore E, Barrett L, Borner G, Davies A, Sahin M, Ebrahimi-Fakhari D. Res Sq. 2023 Jun 12:rs.3.rs-3036166. doi: 10.21203/rs.3.rs-3036166/v1. Preprint. PubMed |
| Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons. Sheta R, Teixeira M, Idi W, Oueslati A. STAR Protoc. 2023 Jul 28;4(3):102486. doi: 10.1016/j.xpro.2023.102486. PubMed |
| The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies. Liou RH, Chen SW, Cheng HC, Wu PC, Chang YF, Wang AG, Fann MJ, Wong YH. Cell Mol Life Sci. 2023 Aug 4;80(8):239. doi: 10.1007/s00018-023-04890-w. PubMed |
| FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells. Park SHE, Kulkarni A, Konopka G. PLoS Biol. 2023 Aug 4;21(8):e3001852. doi: 10.1371/journal.pbio.3001852. eCollection 2023 Aug. PubMed |
| Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression. Liu Y, Wang J, Sudhof TC, Wernig M. Nat Protoc. 2023 Oct;18(10):2954-2974. doi: 10.1038/s41596-023-00863-2. Epub 2023 Aug 18. PubMed |
| Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1. Lee H, Aylward AJ, Pearse RV 2nd, Lish AM, Hsieh YC, Augur ZM, Benoit CR, Chou V, Knupp A, Pan C, Goberdhan S, Duong DM, Seyfried NT, Bennett DA, Taga MF, Huynh K, Arnold M, Meikle PJ, De Jager PL, Menon V, Young JE, Young-Pearse TL. Cell Rep. 2023 Aug 29;42(8):112994. doi: 10.1016/j.celrep.2023.112994. Epub 2023 Aug 22. PubMed |
| Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths. Vainorius G, Novatchkova M, Michlits G, Baar JC, Raupach C, Lee J, Yelagandula R, Wernig M, Elling U. Nat Commun. 2023 Sep 2;14(1):5341. doi: 10.1038/s41467-023-40803-y. PubMed |
| Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons. Zhang S, Zhang H, Forrest MP, Zhou Y, Sun X, Bagchi VA, Kozlova A, Santos MD, Piguel NH, Dionisio LE, Sanders AR, Pang ZP, He X, Penzes P, Duan J. Cell Genom. 2023 Aug 28;3(9):100399. doi: 10.1016/j.xgen.2023.100399. eCollection 2023 Sep 13. PubMed |
| Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation. Meng L. Cell Death Discov. 2023 Oct 20;9(1):384. doi: 10.1038/s41420-023-01639-z. PubMed |
| Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing. Nguyen LD, Wei Z, Silva MC, Barberan-Soler S, Zhang J, Rabinovsky R, Muratore CR, Stricker JMS, Hortman C, Young-Pearse TL, Haggarty SJ, Krichevsky AM. Nat Commun. 2023 Nov 21;14(1):7575. doi: 10.1038/s41467-023-43293-0. PubMed |
| An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds. Zhao C, Rollo B, Shahid Javaid M, Huang Z, He W, Xu H, Kwan P, Zhang C. J Adv Res. 2024 Oct;64:249-262. doi: 10.1016/j.jare.2023.11.022. Epub 2023 Nov 22. PubMed |
| Generation of a stably transfected mouse embryonic stem cell line for inducible differentiation to excitatory neurons. Gu J, Rollo B, Berecki G, Petrou S, Kwan P, Sumer H, Cromer B. Exp Cell Res. 2024 Feb 1;435(1):113902. doi: 10.1016/j.yexcr.2023.113902. Epub 2023 Dec 24. PubMed |
| Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function SCN2A Developmental and Epileptic Encephalopathy. Mao M, Mattei C, Rollo B, Byars S, Cuddy C, Berecki G, Heighway J, Pachernegg S, Menheniott T, Apted D, Jia L, Dalby K, Nemiroff A, Mullen S, Reid CA, Maljevic S, Petrou S. J Neurosci. 2024 Feb 21;44(8):e0692232023. doi: 10.1523/JNEUROSCI.0692-23.2023. PubMed |
| High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia. Saffari A, Brechmann B, Boger C, Saber WA, Jumo H, Whye D, Wood D, Wahlster L, Alecu JE, Ziegler M, Scheffold M, Winden K, Hubbs J, Buttermore ED, Barrett L, Borner GHH, Davies AK, Ebrahimi-Fakhari D, Sahin M. Nat Commun. 2024 Jan 17;15(1):584. doi: 10.1038/s41467-023-44264-1. PubMed |
| Protocol for neurogenin-2-mediated induction of human stem cell-derived neural progenitor cells. Guss EJ, Sathe L, Dai A, Derebenskiy T, Vega AR, Eggan K, Wells MF. STAR Protoc. 2024 Mar 15;5(1):102878. doi: 10.1016/j.xpro.2024.102878. Epub 2024 Feb 8. PubMed |
| ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO. Chatterjee D, D'Brant LY, Hiller BM, Marmion DJ, Sandoval IM, Luk KC, Manfredsson FP, Messer A, Kordower JH, Butler DC. Res Sq [Preprint]. 2024 Mar 28:rs.3.rs-4088206. doi: 10.21203/rs.3.rs-4088206/v1. PubMed |
| KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons. Guerra San Juan I, Brunner J, Eggan K, Toonen RF, Verhage M. bioRxiv [Preprint]. 2024 Sep 11:2024.09.06.611684. doi: 10.1101/2024.09.06.611684. PubMed |
| KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons. Guerra San Juan I, Brunner JW, Eggan K, Toonen RF, Verhage M. Neurobiol Dis. 2025 Jan;204:106759. doi: 10.1016/j.nbd.2024.106759. Epub 2024 Dec 5. PubMed |
| Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late-Onset Alzheimer's Disease. Lee H, Pearse RV 2nd, Lish AM, Pan C, Augur ZM, Terzioglu G, Gaur P, Liao M, Fujita M, Tio ES, Duong DM, Felsky D, Seyfried NT, Menon V, Bennett DA, De Jager PL, Young-Pearse TL. Glia. 2025 Jun;73(6):1166-1187. doi: 10.1002/glia.24677. Epub 2025 Feb 3. PubMed |
| The Hippo pathway effector YAP inhibits NF-kappaB signaling and ccRCC growth by opposing ZHX2. Li X, Cho YS, Han Y, Zhou M, Liu Y, Yang Y, Zhuo S, Jiang J. J Biol Chem. 2025 May;301(5):108430. doi: 10.1016/j.jbc.2025.108430. Epub 2025 Mar 20. PubMed |
| CLU alleviates Alzheimer's disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density. Lish AM, Grogan EFL, Benoit CR, Pearse RV 2nd, Heuer SE, Luquez T, Orme GA, Galle PC, Milinkeviciute G, Green KN, Alexander KD, Fancher SB, Stern AM, Fujita M, Bennett DA, Seyfried NT, De Jager PL, Menon V, Young-Pearse TL. Neuron. 2025 Jun 18;113(12):1925-1946.e11. doi: 10.1016/j.neuron.2025.03.034. Epub 2025 Apr 30. PubMed |
| Experimental evidence that readily diffusible forms of Abeta from Alzheimer's disease brain have seeding activity. Song S, Liu Q, Chen R, Chen P, Tao M, Li S, Guo L, Zhu X, Liu Y, Liu L, Sasaguri H, Saito T, Saido TC, Walsh DM, Zhang Z, Hong W. Acta Neuropathol Commun. 2025 May 24;13(1):112. doi: 10.1186/s40478-025-02032-w. PubMed |
| Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation. Meli M, Swiderski K, Gu J, Rollo B, Bartlett B, Caldow MK, Lynch GS, Kwan P, Sumer H, Cromer B. Biomolecules. 2025 Apr 29;15(5):637. doi: 10.3390/biom15050637. PubMed |
| Generation of iPSC Lines with Tagged alpha-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders. Zetterdahl OG, Crowe JA, Reyhani S, Gura MA, Labastida-Botey O, Girard AS, Froese DS, Ahlenius H, Canals I. eNeuro. 2025 Jun 23;12(6):ENEURO.0093-25.2025. doi: 10.1523/ENEURO.0093-25.2025. Print 2025 Jun. PubMed |
| Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, alpha-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice. Nuber S, Hsiang H, Keewan E, Moors TE, Reitz SJ, Tiwari A, Ho GP, Su E, Hahn W, Adom MA, Pathak R, Blizzard M, Kim S, Ko HS, Zhang X, Svenningsson P, Selkoe DJ, Fanning S. JCI Insight. 2025 Jun 3;10(13):e188413. doi: 10.1172/jci.insight.188413. eCollection 2025 Jul 8. PubMed |
| The ADCY1-mediated cAMP signaling pathway mediates functional effects of montelukast treatment in brain organoids. Xu Z, Yan H, Wang B, Wang H, Xia Y, Wan J, Jiang J, Zeng L, Tang B, Meng Q. Cell Mol Life Sci. 2025 Jun 5;82(1):224. doi: 10.1007/s00018-025-05764-z. PubMed |
| Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures. Lish AM, Ashour N, Pearse RV 2nd, Galle PC, Orme GA, Heuer SE, Benoit CR, Alexander KD, Grogan EFL, Terzioglu G, Scarpa A, Stern AM, Seyfried N, Menon V, Young-Pearse TL. Cell Rep. 2025 Jun 24;44(6):115777. doi: 10.1016/j.celrep.2025.115777. Epub 2025 Jun 3. PubMed |
| An improved immunoassay detects Abeta oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels. Yang T, Xu YR, Jin S, Ramalingam N, Bellier JP, Lish AM, Ostaszewski BL, Young-Pearse T, Liu L, Yang HS, Chhatwal JP, Lawton TL, Selkoe DJ. Alzheimers Res Ther. 2025 Jul 12;17(1):153. doi: 10.1186/s13195-025-01802-x. PubMed |
| Lysosomal Protease-Mediated APP Degradation is pH-Dependent, Mutation-Sensitive, and Facilitates Tau Proteolysis. Ackley C, Liau Z, Arya S, Antee T, Knudsen GM, Lane-Donovan C, Sampognaro PJ, Kao AW. Res Sq [Preprint]. 2025 Jul 10:rs.3.rs-6978813. doi: 10.21203/rs.3.rs-6978813/v1. PubMed |
| Machine Learning Resolves Functional Phenotypes and Therapeutic Responses in KCNQ2 Developmental Epileptic Encephalopathy iPSC Models. Simkin D, Wafa SMA, Gharib M, Marshall KA, Yang Y, Laux LC, George AL, Kiskinis E. bioRxiv [Preprint]. 2025 Jul 31:2025.07.26.666977. doi: 10.1101/2025.07.26.666977. PubMed |
| Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons. Augur ZM, Fogo GM, Arbery MR, Stern AM, Benoit CR, Hsieh YC, Young-Pearse TL. Acta Neuropathol Commun. 2025 Sep 2;13(1):188. doi: 10.1186/s40478-025-02103-y. PubMed |
| Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis. Savchuk S, Gentry KM, Wang W, Carleton E, Biagi-Junior CAO, Luthria K, Yalcin B, Ni L, Farnsworth HC, Davis RA, Drexler R, Melms JC, Liu Y, Acosta-Alvarez L, Hartmann GG, Pavarino EC, LaBelle J, Woo PJ, Toland AM, Qu F, Kim YS, Filbin MG, Krasnow MA, Ligon KL, Izar B, Sage J, Sabatini BL, Monje M, Venkatesh HS. Nature. 2025 Oct;646(8087):1232-1242. doi: 10.1038/s41586-025-09492-z. Epub 2025 Sep 10. PubMed |
| The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases. Feringa FM, Koppes-den Hertog SJ, Wang LY, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pompner N, Blomberg N, Olivier-Jimenez D, Johansen LE, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward ME, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, Thompson LM, Ori A, Mohammed Y, Giera M, van der Kant R. Nat Metab. 2025 Oct;7(10):2142-2164. doi: 10.1038/s42255-025-01365-z. Epub 2025 Sep 22. PubMed |
| Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis. Augur ZM, Fogo GM, Arbery MR, Hsieh YC, Rao NR, Goyal K, Dexter E, Bennett DA, Savas JN, Stern AM, Young-Pearse TL. Acta Neuropathol. 2025 Oct 14;150(1):43. doi: 10.1007/s00401-025-02947-7. PubMed |
| Protocol for generating a human iPSC-derived tri-culture model to study interactions between neurons, astrocytes, and microglia. Lish AM, Galle PC, Orme GA, Ashour N, Heuer SE, Curle AJ, Muratore CR, Young-Pearse TL. STAR Protoc. 2025 Oct 22;6(4):104152. doi: 10.1016/j.xpro.2025.104152. PubMed |
| SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes differential accumulation of HIF1a and phosphorylated tau. Kettunen P, Ruuska J, Quirin T, Ojha R, Saber SH, Sng JDJ, Morrison S, Al-Mhanawi B, Shaker MR, De Neck S, Kipar A, Paavolainen L, Wolvetang E, Joensuu M, Koistinaho J, Rolova T, Balistreri G. Mol Ther Nucleic Acids. 2025 Sep 30;36(4):102726. doi: 10.1016/j.omtn.2025.102726. eCollection 2025 Dec 9. PubMed |
| Protective ApoE variants support neuronal function by effluxing oxidized phospholipids. Ralhan I, Do AD, Bae JY, Feringa FM, Cai W, Chang J, Chik K, Lee NYJ, Gerry CJ, van der Kant R, Jackson J, Ricq EL, Ioannou MS. Neuron. 2025 Dec 2:S0896-6273(25)00847-5. doi: 10.1016/j.neuron.2025.10.040. PubMed |
If you have published an article using this material, please email us at [email protected] to have your article added to this page.