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pLV-dCas9-p300-P2A-PuroR Citations (9)

Originally described in: CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.
Klann TS, Black JB, Chellappan M, Safi A, Song L, Hilton IB, Crawford GE, Reddy TE, Gersbach CA Nat Biotechnol. 2017 Apr 3. doi: 10.1038/nbt.3853.
PubMed Journal

Articles Citing pLV-dCas9-p300-P2A-PuroR

Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing. Klann TS, Crawford GE, Reddy TE, Gersbach CA. Methods Mol Biol. 2018;1767:447-480. doi: 10.1007/978-1-4939-7774-1_25. PubMed
Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31. Ray-Jones H, Duffus K, McGovern A, Martin P, Shi C, Hankinson J, Gough O, Yarwood A, Morris AP, Adamson A, Taylor C, Ding J, Gaddi VP, Fu Y, Gaffney P, Orozco G, Warren RB, Eyre S. BMC Biol. 2020 May 4;18(1):47. doi: 10.1186/s12915-020-00779-3. PubMed
KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain. Lipinski M, Munoz-Viana R, Del Blanco B, Marquez-Galera A, Medrano-Relinque J, Carames JM, Szczepankiewicz AA, Fernandez-Albert J, Navarron CM, Olivares R, Wilczynski GM, Canals S, Lopez-Atalaya JP, Barco A. Nat Commun. 2020 May 22;11(1):2588. doi: 10.1038/s41467-020-16246-0. PubMed
Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis. Yang J, McGovern A, Martin P, Duffus K, Ge X, Zarrineh P, Morris AP, Adamson A, Fraser P, Rattray M, Eyre S. Nat Commun. 2020 Sep 2;11(1):4402. doi: 10.1038/s41467-020-18180-7. PubMed
Epigenome editing of the CFTR-locus for treatment of cystic fibrosis. Kabadi AM, Machlin L, Dalal N, Lee RE, McDowell I, Shah NN, Drowley L, Randell SH, Reddy TE. J Cyst Fibros. 2021 May 25. pii: S1569-1993(21)00118-1. doi: 10.1016/j.jcf.2021.04.008. PubMed
Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators. Beyersdorf JP, Bawage S, Iglesias N, Peck HE, Hobbs RA, Wroe JA, Zurla C, Gersbach CA, Santangelo PJ. ACS Nano. 2022 Mar 31. doi: 10.1021/acsnano.1c10631. PubMed
Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure. Bohnsack JP, Zhang H, Wandling GM, He D, Kyzar EJ, Lasek AW, Pandey SC. Sci Adv. 2022 May 6;8(18):eabn2748. doi: 10.1126/sciadv.abn2748. Epub 2022 May 4. PubMed
Comparative analysis of dCas9-VP64 variants and multiplexed guide RNAs mediating CRISPR activation. Omachi K, Miner JH. PLoS One. 2022 Jun 28;17(6):e0270008. doi: 10.1371/journal.pone.0270008. eCollection 2022. PubMed

Associated Plasmids

Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions. Wang K, Escobar M, Li J, Mahata B, Goell J, Shah S, Cluck M, Hilton IB. Nucleic Acids Res. 2022 Aug 12;50(14):7842-7855. doi: 10.1093/nar/gkac582. PubMed

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