Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected]. Learn more


HA Raptor Citations (21)

Originally described in: mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM Cell 2002 Jul 26;110(2):163-75.
PubMed Journal

Articles Citing HA Raptor

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Dunlop EA, Dodd KM, Seymour LA, Tee AR. Cell Signal. 2009 Mar 9. ():. PubMed
A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Cully M, Genevet A, Warne P, Treins C, Liu T, Bastien J, Baum B, Tapon N, Leevers SJ, Downward J. Mol Cell Biol. 2010 Jan;30(2):481-95. doi: 10.1128/MCB.00688-09. Epub 2009 Nov 16. PubMed
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. Soliman GA, Acosta-Jaquez HA, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC. J Biol Chem. 2010 Mar 12. 285(11):7866-79. PubMed
ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Dunlop EA, Hunt DK, Acosta-Jaquez HA, Fingar DC, Tee AR. Autophagy. 2011 Jul;7(7):737-47. Epub 2011 Jul 1. PubMed
mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC. Mol Cell Biol. 2011 Jul;31(14):2787-801. doi: 10.1128/MCB.05437-11. Epub 2011 May 16. PubMed
Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons. Urbanska M, Gozdz A, Swiech LJ, Jaworski J. J Biol Chem. 2012 Aug 31;287(36):30240-56. doi: 10.1074/jbc.M112.374405. Epub 2012 Jul 18. PubMed
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Su KH, Cao J, Tang Z, Dai S, He Y, Sampson SB, Benjamin IJ, Dai C. Nat Cell Biol. 2016 May;18(5):527-39. doi: 10.1038/ncb3335. Epub 2016 Apr 4. PubMed
Recurrent mutations in the MTOR regulator RRAGC in follicular lymphoma. Ying ZX, Jin M, Peterson LF, Bernard D, Saiya-Cork K, Yildiz M, Wang S, Kaminski M, Chang A, Klionsky DJ, Malek S. Clin Cancer Res. 2016 Jun 7. pii: clincanres.0609.2016. PubMed
Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death. Martin R, Desponds C, Eren RO, Quadroni M, Thome M, Fasel N. Cell Death Discov. 2016 Apr 18;2:16024. doi: 10.1038/cddiscovery.2016.24. eCollection 2016. PubMed
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MA, Baumeister R, Hansen M, Thedieck K. Autophagy. 2017 Mar 4;13(3):486-505. doi: 10.1080/15548627.2016.1263781. Epub 2017 Jan 19. PubMed
MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1. Brown MC, Gromeier M. Cell Rep. 2017 Feb 7;18(6):1444-1457. doi: 10.1016/j.celrep.2017.01.023. PubMed
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. Mol Cell. 2017 Jul 6;67(1):128-138.e7. doi: 10.1016/j.molcel.2017.05.030. Epub 2017 Jun 22. PubMed
Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit. Meade N, Furey C, Li H, Verma R, Chai Q, Rollins MG, DiGiuseppe S, Naghavi MH, Walsh D. Cell. 2018 Aug 23;174(5):1143-1157.e17. doi: 10.1016/j.cell.2018.06.053. Epub 2018 Aug 2. PubMed
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Son SM, Park SJ, Lee H, Siddiqi F, Lee JE, Menzies FM, Rubinsztein DC. Cell Metab. 2019 Jan 8;29(1):192-201.e7. doi: 10.1016/j.cmet.2018.08.013. Epub 2018 Sep 6. PubMed

Associated Plasmids

Headcase and Unkempt Regulate Tissue Growth and Cell Cycle Progression in Response to Nutrient Restriction. Li N, Liu Q, Xiong Y, Yu J. Cell Rep. 2019 Jan 15;26(3):733-747.e3. doi: 10.1016/j.celrep.2018.12.086. PubMed
TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877. Antonia RJ, Castillo J, Herring LE, Serafin DS, Liu P, Graves LM, Baldwin AS, Hagan RS. Sci Rep. 2019 Sep 17;9(1):13470. doi: 10.1038/s41598-019-49707-8. PubMed
Endogenous T cells prevent tumor immune escape following adoptive T cell therapy. Walsh SR, Simovic B, Chen L, Bastin D, Nguyen A, Stephenson K, Mandur TS, Bramson JL, Lichty BD, Wan Y. J Clin Invest. 2019 Dec 2;129(12):5400-5410. doi: 10.1172/JCI126199. PubMed
Leucine regulates autophagy via acetylation of the mTORC1 component raptor. Son SM, Park SJ, Stamatakou E, Vicinanza M, Menzies FM, Rubinsztein DC. Nat Commun. 2020 Jun 19;11(1):3148. doi: 10.1038/s41467-020-16886-2. PubMed
mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation. Majeed ST, Batool A, Majeed R, Bhat NN, Zargar MA, Andrabi KI. Cell Cycle. 2021 May;20(9):839-854. doi: 10.1080/15384101.2021.1901038. Epub 2021 May 3. PubMed
An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Nuchel J, Tauber M, Nolte JL, Morgelin M, Turk C, Eckes B, Demetriades C, Plomann M. Mol Cell. 2021 Aug 19;81(16):3275-3293.e12. doi: 10.1016/j.molcel.2021.06.017. Epub 2021 Jul 9. PubMed
Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation. Li TY, Wang Q, Gao AW, Li X, Sun Y, Mottis A, Shong M, Auwerx J. Cell Discov. 2023 Sep 7;9(1):92. doi: 10.1038/s41421-023-00589-1. PubMed

If you have published an article using this material, please email us at [email protected] to have your article added to this page.