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1477 pcDNA3 flag HA Akt1 Citations (22)

Originally described in: A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens.
Hsieh AC, Bo R, Manola J, Vazquez F, Bare O, Khvorova A, Scaringe S, Sellers WR Nucleic Acids Res. 2004 . 32(3):893-901.
PubMed Journal

Articles Citing 1477 pcDNA3 flag HA Akt1

The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells. Dormond O, Madsen JC, Briscoe DM. J Biol Chem. 2007 Aug 10. 282(32):23679-86. PubMed
Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Martin VA, Wang WH, Lipchik AM, Parker LL, He Y, Zhang S, Zhang ZY, Geahlen RL. Cell Signal. 2012 May;24(5):1064-73. doi: 10.1016/j.cellsig.2012.01.001. Epub 2012 Jan 11. PubMed
Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD Jr, Suh H, Couillard-Despres S, Aigner L, Gage FH, Jessberger S. J Neurosci. 2012 Mar 7;32(10):3376-87. doi: 10.1523/JNEUROSCI.4248-11.2012. PubMed
HSP27 modulates survival signaling networks in cells treated with curcumin and TRAIL. Kim J, Kim SY, Kang S, Yoon HR, Sun BK, Kang D, Kim JH, Song JJ. Cell Signal. 2012 Jul;24(7):1444-52. doi: 10.1016/j.cellsig.2012.03.009. Epub 2012 Mar 15. PubMed
Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells. Shearn CT, Reigan P, Petersen DR. Free Radic Biol Med. 2012 Jul 1;53(1):1-11. doi: 10.1016/j.freeradbiomed.2012.04.021. Epub 2012 May 1. PubMed
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling. Wang S, Huang X, Sun D, Xin X, Pan Q, Peng S, Liang Z, Luo C, Yang Y, Jiang H, Huang M, Chai W, Ding J, Geng M. PLoS One. 2012;7(5):e37427. doi: 10.1371/journal.pone.0037427. Epub 2012 May 22. PubMed
The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBalpha isoform signaling. Sully K, Akinduro O, Philpott MP, Naeem AS, Harwood CA, Reeve VE, O'Shaughnessy RF, Byrne C. Oncogene. 2013 Jul 4;32(27):3254-62. doi: 10.1038/onc.2012.338. Epub 2012 Aug 13. PubMed
Coordinated targeting of the EGFR signaling axis by microRNA-27a*. Wu X, Bhayani MK, Dodge CT, Nicoloso MS, Chen Y, Yan X, Adachi M, Thomas L, Galer CE, Jiffar T, Pickering CR, Kupferman ME, Myers JN, Calin GA, Lai SY. Oncotarget. 2013 Sep;4(9):1388-98. PubMed
Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities. Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU. Biochem Biophys Res Commun. 2013 Oct 18;440(2):277-82. doi: 10.1016/j.bbrc.2013.09.077. Epub 2013 Sep 23. PubMed
Mutant AKT1-E17K is oncogenic in lung epithelial cells. De Marco C, Malanga D, Rinaldo N, De Vita F, Scrima M, Lovisa S, Fabris L, Carriero MV, Franco R, Rizzuto A, Baldassarre G, Viglietto G. Oncotarget. 2015 May 25. PubMed
Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells. Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML. Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22. PubMed
SIRT1 at the crossroads of AKT1 and ERbeta in malignant pleural mesothelioma cells. Pinton G, Zonca S, Manente AG, Cavaletto M, Borroni E, Daga A, Jithesh PV, Fennell D, Nilsson S, Moro L. Oncotarget. 2016 Mar 22;7(12):14366-79. doi: 10.18632/oncotarget.7321. PubMed
Insufficient activation of Akt upon reperfusion because of its novel modification by reduced PP2A-B55alpha contributes to enlargement of infarct size by chronic kidney disease. Tobisawa T, Yano T, Tanno M, Miki T, Kuno A, Kimura Y, Ishikawa S, Kouzu H, Nishizawa K, Yoshida H, Miura T. Basic Res Cardiol. 2017 May;112(3):31. doi: 10.1007/s00395-017-0621-6. Epub 2017 Apr 18. PubMed
RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex. Fei L, Ma Y, Zhang M, Liu X, Luo Y, Wang C, Zhang H, Zhang W, Han Y. Oncotarget. 2017 Jun 20;8(25):40501-40513. doi: 10.18632/oncotarget.17120. PubMed
Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP. Valentino E, Bellazzo A, Di Minin G, Sicari D, Apollonio M, Scognamiglio G, Di Bonito M, Botti G, Del Sal G, Collavin L. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7623-7628. doi: 10.1073/pnas.1700996114. Epub 2017 Jun 30. PubMed
Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA. Cell. 2018 Aug 9;174(4):897-907.e14. doi: 10.1016/j.cell.2018.07.003. Epub 2018 Aug 2. PubMed
Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis. Yue X, Wu F, Li Y, Liu J, Boateng M, Mandava K, Zhang C, Feng Z, Gao J, Hu W. Cell Cycle. 2020 Jun;19(11):1338-1351. doi: 10.1080/15384101.2020.1749790. Epub 2020 Apr 10. PubMed
Akt phosphorylation regulated by IKKepsilon in response to low shear stress leads to endothelial inflammation via activating IRF3. Zhu L, Yang H, Chao Y, Gu Y, Zhang J, Wang F, Yu W, Ye P, Chu P, Kong X, Chen S. Cell Signal. 2021 Apr;80:109900. doi: 10.1016/j.cellsig.2020.109900. Epub 2020 Dec 25. PubMed
A growth-factor-activated lysosomal K(+) channel regulates Parkinson's pathology. Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. Nature. 2021 Mar;591(7850):431-437. doi: 10.1038/s41586-021-03185-z. Epub 2021 Jan 27. PubMed
The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt. Tooley AS, Kazyken D, Bodur C, Gonzalez IE, Fingar DC. J Biol Chem. 2021 Aug;297(2):100942. doi: 10.1016/j.jbc.2021.100942. Epub 2021 Jul 8. PubMed
A role for AKT1 in nonsense-mediated mRNA decay. Palma M, Leroy C, Salome-Desnoulez S, Werkmeister E, Kong R, Mongy M, Le Hir H, Lejeune F. Nucleic Acids Res. 2021 Nov 8;49(19):11022-11037. doi: 10.1093/nar/gkab882. PubMed
RUNDC3A regulates SNAP25-mediated chemotherapy resistance by binding AKT in gastric neuroendocrine carcinoma (GNEC). Chen P, Wang W, Wong SW, Li J, Wu Q, Zhang SD, Lin Y, Kwok HF. Cell Death Discov. 2022 Jun 25;8(1):296. doi: 10.1038/s41420-022-01084-4. PubMed

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