Human CRISPRa sgRNA library Calabrese in backbone XPR_502 (P65 HSF), Set A Citations (16)
Originally described in: Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities.Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG Nat Commun. 2018 Dec 21;9(1):5416. doi: 10.1038/s41467-018-07901-8. PubMed Journal
Articles Citing Human CRISPRa sgRNA library Calabrese in backbone XPR_502 (P65 HSF), Set A
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| Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors. Schleicher EM, Dhoonmoon A, Jackson LM, Clements KE, Stump CL, Nicolae CM, Moldovan GL. PLoS Genet. 2020 Nov 2;16(11):e1009176. doi: 10.1371/journal.pgen.1009176. eCollection 2020 Nov. PubMed |
| Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens. Clements KE, Schleicher EM, Thakar T, Hale A, Dhoonmoon A, Tolman NJ, Sharma A, Liang X, Imamura Kawasawa Y, Nicolae CM, Wang HG, De S, Moldovan GL. Nat Commun. 2020 Nov 30;11(1):6118. doi: 10.1038/s41467-020-19961-w. PubMed |
CRISPR activation and interference screens decode stimulation responses in primary human T cells.
Schmidt R, Steinhart Z, Layeghi M, Freimer JW, Bueno R, Nguyen VQ, Blaeschke F, Ye CJ, Marson A.
Science. 2022 Feb 4;375(6580):eabj4008. doi: 10.1126/science.abj4008. Epub 2022 Feb 4.
PubMed
Associated Plasmids |
| Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection. Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schafer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. Nat Genet. 2022 Aug;54(8):1078-1089. doi: 10.1038/s41588-022-01131-x. Epub 2022 Jul 25. PubMed |
| Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction. Fujihara KM, Zhang BZ, Jackson TD, Ogunkola MO, Nijagal B, Milne JV, Sallman DA, Ang CS, Nikolic I, Kearney CJ, Hogg SJ, Cabalag CS, Sutton VR, Watt S, Fujihara AT, Trapani JA, Simpson KJ, Stojanovski D, Leimkuhler S, Haupt S, Phillips WA, Clemons NJ. Sci Adv. 2022 Sep 16;8(37):eabm9427. doi: 10.1126/sciadv.abm9427. Epub 2022 Sep 14. PubMed |
| ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection. Zhu X, Trimarco JD, Williams CA, Barrera A, Reddy TE, Heaton NS. Cell Rep. 2022 Oct 25;41(4):111540. doi: 10.1016/j.celrep.2022.111540. Epub 2022 Oct 5. PubMed |
| Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection. Trimarco JD, Nelson SL, Chaparian RR, Wells AI, Murray NB, Azadi P, Coyne CB, Heaton NS. Nat Commun. 2022 Oct 29;13(1):6456. doi: 10.1038/s41467-022-34111-0. PubMed |
| Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. Loo L, Waller MA, Moreno CL, Cole AJ, Stella AO, Pop OT, Jochum AK, Ali OH, Denes CE, Hamoudi Z, Chung F, Aggarwal A, Low JKK, Patel K, Siddiquee R, Kang T, Mathivanan S, Mackay JP, Jochum W, Flatz L, Hesselson D, Turville S, Neely GG. PLoS Biol. 2023 Feb 9;21(2):e3001967. doi: 10.1371/journal.pbio.3001967. eCollection 2023 Feb. PubMed |
| Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones. Liang D, Feng Y, Zandkarimi F, Wang H, Zhang Z, Kim J, Cai Y, Gu W, Stockwell BR, Jiang X. Cell. 2023 Jun 22;186(13):2748-2764.e22. doi: 10.1016/j.cell.2023.05.003. Epub 2023 Jun 1. PubMed |
| LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma. Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Buchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Florez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP. EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12. PubMed |
| The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities. Ramberger E, Sapozhnikova V, Ng YLD, Dolnik A, Ziehm M, Popp O, Strang E, Kull M, Grunschlager F, Kruger J, Benary M, Muller S, Gao X, Murgai A, Haji M, Schmidt A, Lutz R, Nogai A, Braune J, Laue D, Langer C, Khandanpour C, Bassermann F, Dohner H, Engelhardt M, Straka C, Hundemer M, Beule D, Haas S, Keller U, Einsele H, Bullinger L, Knop S, Mertins P, Kronke J. Nat Cancer. 2024 Aug;5(8):1267-1284. doi: 10.1038/s43018-024-00784-3. Epub 2024 Jun 28. PubMed |
| Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems. Maddineni A, Liang Z, Jambardi S, Roy S, Tycko J, Patil A, Manzano M, Gottwein E. bioRxiv [Preprint]. 2024 Sep 23:2024.09.23.614524. doi: 10.1101/2024.09.23.614524. PubMed |
| Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling. Wurth R, Donato E, Michel LL, Saini M, Becker L, Cheytan T, Doncevic D, Messmer T, Gutjahr E, Weber R, Klein C, Alborzinia H, Yildiz U, Vogel V, Hlevnjak M, Kozyulina P, Neuberth SJ, Schwerd-Kleine P, Jakab S, Pfarr N, Angeles AK, Laut AK, Karpova D, Falcone M, Hardt O, Theek B, Wagner CV, Becker M, Wagner S, Haselmayr M, Schmitt A, Muller-Tidow C, Riethdorf S, Pantel K, Zapatka M, Sultmann H, Herrmann C, Thewes V, Lichter P, Schneeweiss A, Sprick MR, Trumpp A. Nat Cancer. 2025 Jan;6(1):67-85. doi: 10.1038/s43018-024-00882-2. Epub 2025 Jan 3. PubMed |
| dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening. Allen TP, Roennfeldt AE, Reckdharajkumar M, Sullivan AE, Liu M, Quinn RJ, Russell DL, Peet DJ, Whitelaw ML, Bersten DC. Nat Commun. 2025 Apr 7;16(1):3298. doi: 10.1038/s41467-025-58488-w. PubMed |
| Soluble MFGE8 mediates cell entry of Crimean-Congo hemorrhagic fever virus. Ma X, Xu Z-S, Fu Y, Ma Y, Du W-T, Li Q, Zhan R, Tian S, Yang L, Wang Z, Feng F, Gao Z, Wang M, Cao S, Wang Y-Y, Zhang R. mBio. 2025 Oct 8;16(10):e0161725. doi: 10.1128/mbio.01617-25. Epub 2025 Aug 25. PubMed |
| Cytotoxicity of activator expression in CRISPR-based transcriptional activation systems. Liang Z, Maddineni A, Ortega JA, Magdongon CB, Jambardi S, Roy S, Tycko J, Patil A, Manzano M, Bartom ET, Gottwein E. Nat Commun. 2025 Aug 29;16(1):8071. doi: 10.1038/s41467-025-63570-4. PubMed |
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