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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.
Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM
Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
69006pcDNA3-FLAG-MTOR-L1460Pactivating MTOR mutation
69008pcDNA3-FLAG-MTOR-C1483Factivating MTOR mutation
69009pcDNA3-FLAG-MTOR-E1799Kactivating MTOR mutation
69010pcDNA3-FLAG-MTOR-F1888Lactivating MTOR mutation
69011pcDNA3-FLAG-MTOR-T1977Ractivating MTOR mutation
69012pcDNA3-FLAG-MTOR-V2006Iactivating MTOR mutation
69013pcDNA3-FLAG-MTOR-S2215Yactivating MTOR mutation
69014pcDNA3-FLAG-MTOR-I2500Factivating MTOR mutation
69015pcDNA3-FLAG-MTOR-R2505Pactivating MTOR mutation
69017pcDNA3-FLAG-MTOR-D2512Hactivating MTOR mutation
69018pRK5-HA-GST-4EBP1-Low GCexpresses tagged 4EBP1

Antibodies from Article