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A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds.

Kubben N, Brimacombe KR, Donegan M, Li Z, Misteli T
Methods. 2015 Sep 1. pii: S1046-2023(15)30070-0. doi: 10.1016/j.ymeth.2015.08.024. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
118709pLenti CMV TRE3G Neo GFP-Lamin A wildtypeLentiviral TET-ON inducible GFP-Lamin A wildtype
118710pLenti CMV TRE3G Neo GFP-ProgerinLentiviral TET-ON inducible GFP-Progerin
118711pLenti CMV TRE3G Neo GFP-Progerin C661SLentiviral TET-ON inducible GFP-Progerin C661S (Farnesylation mutant)

Antibodies from Article