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A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs.
Melero-Fernandez de Mera RM, Li LL, Popinigis A, Cisek K, Tuittila M, Yadav L, Serva A, Courtney MJ
Nat Commun. 2017 May 12;8:15017. doi: 10.1038/ncomms15017.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
89738pKCAG-mCherry-OptoJNKiExpression of light-regulated JNK inhibitor, wild-type photosensor, inhibitor JIP11
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89739pmCherry-NES-OptoJNKiExpression of light-regulated JNK inhibitor, mCherry-tagged, localised to cytoplasm, wild-type photosensor, inhibitor JIP11
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89740pmCherry-3xNLS-OptoJNKiExpression of light-regulated JNK inhibitor, mCherry-tagged, localised to nucleus, wild-type photosensor, inhibitor JIP11
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89741pKCAG-H2BmCherry-OptoJNKiExpression of light-regulated JNK inhibitor, mCherry-tagged, localised to chromatin with H2B, wild-type photosensor, inhibitor JIP11
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89742pmCherry-3xNLS-OptoJNKi-lsmExpression of light-regulated JNK inhibitor, mCherry-tagged, localised to nucleus, lit-state mutant photosensor (AsLov2Ja.I539E), inhibitor JIP11
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89743pmCherry-3xNLS-OptoJNKi-dsmExpression of light-regulated JNK inhibitor, mCherry-tagged, localised to nucleus, dark-state mutant photosensor (AsLov2Ja.C450A), inhibitor JIP11
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89744pLuc-OptoJNKiExpression of light-regulated JNK inhibitor, firefly luciferase-fused, wild-type photosensor, inhibitor JIP11
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89745pLuc-OptoJNKi-dsmExpression of light-regulated JNK inhibitor, firefly luciferase-fused, dark-state mutant photosensor (AsLov2Ja.C450A), inhibitor JIP11
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89746pLuc-OptoJNKi-lsmExpression of light-regulated JNK inhibitor, firefly luciferase-fused, lit-state mutant photosensor (AsLov2Ja.I539E), inhibitor JIP11
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89747pLuc-Optop38i-lsmExpression of light-regulated p38 inhibitor, firefly luciferase-fused, lit-state mutant photosensor (AsLov2Ja.I539E), inhibitor MK3BD3-13F
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89748pLuc-Optop38i-dsmExpression of light-regulated p38 inhibitor, firefly luciferase-fused, dark-state mutant photosensor (AsLov2Ja.C450A), inhibitor MK3BD3-13F
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89749pYpet-Optop38iExpression of light-regulated p38 inhibitor, Ypet-fused, wild-type photosensor, inhibitor MK3BD3-13F
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