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Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

Li Z, Gakovic M, Ragimbeau J, Eloranta ML, Ronnblom L, Michel F, Pellegrini S
J Immunol. 2013 Mar 1;190(5):2335-44. doi: 10.4049/jimmunol.1203118. Epub 2013 Jan 28. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
139350pRC/CMV-TYK2P1104A-VSVExpression of the TYK2-P1104A variant, rs34536443
139351pRC/CMV-TYK2VF/PA-VSVExpression of the double mutant of TYK2-V678F-P1104A
139357pRC/CMV-JAK1K908E-VSVExpression of kinase-dead JAK1-K908E protein
139358pRC/CMV-JAK1P1084A-VSVExpression of the catalytically impaired JAK1-P1084A mutant (corresponding to TYK2-P1104A)

Antibodies from Article