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Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling.
Loganathan SK, Schleicher K, Malik A, Quevedo R, Langille E, Teng K, Oh RH, Rathod B, Tsai R, Samavarchi-Tehrani P, Pugh TJ, Gingras AC, Schramek D
Science. 2020 Mar 13;367(6483):1264-1269. doi: 10.1126/science.aax0902. PubMed Article

Plasmids from Article

ID Plasmid Purpose
158030pLKO-Cre stuffer v3lenti-viral construct with Cre recombinase and U6 driven sgRNA casette (20bp sgRNA can be cloned by digesting the stuffer 1.8kb with BsmBI). NO Cas9
158032pLKO-Cre stuffer v4lenti-viral construct with Cre recombinase and U6 driven sgRNA casette with modified tracrRNA (20bp sgRNA can be cloned by digesting the stuffer 1.8kb with BsmBI). NO Cas9
158033pCRISPR-Cre stuffer v4lenti-viral construct with Cas9, Cre recombinase and U6 driven sgRNA casette with modified tracr RNA (20bp sgRNA can be cloned by digesting the stuffer 1.8kb with BsmBI)
158034pLKO-Cre sgAdam10 v3lenti-viral construct with Cre recombinase and U6 driven sgRNA against mouse Adam10
158035pLKO-Cre sgRipk4 v3lenti-viral construct with Cre recombinase and U6 driven sgRNA against mouse Ripk4
158036pLKO-Cre sgUroD v4lenti-viral construct with Cre recombinase and U6 driven sgRNA against mouse UroD
158038pLKO-Cre sgItgb5 v3lenti-viral construct with Cre recombinase and U6 driven sgRNA against mouse Itgb5
158046pLKO-CreERT2 stuffer v3lenti-viral construct with tamoxifen inducible Cre recombinase and U6 driven sgRNA casette (20bp sgRNA can be cloned by digesting the stuffer 1.8kb with BsmBI). NO Cas9
158047pLKO-CreERT2 sgAdam10 v3lenti-viral construct with tamoxifen inducible Cre recombinase and U6 driven sgRNA against mouse Adam10. NO Cas9
158048pLKO-CreERT2 sgRipk4 v3lenti-viral construct with tamoxifen inducible Cre recombinase and U6 driven sgRNA against mouse Ripk4. NO Cas9
158049PLX306 iCre tetO NICD rtTAlenti-viral construct with Cre recombinase and doxycycline inducible expression of mouse Notch intracellular domain
158050PLX306 iCre tetO tomato rtTAlenti-viral construct with Cre recombinase and doxycycline inducible expression of tdTomato
158602pLKO-Cre sgAmotl2 v3lenti-viral construct with Cas9, Cre recombinbase and U6 driven sgRNA against mouse Amotl2

Antibodies from Article