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Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity.

Sheppard HE, Dall'Agnese A, Park WD, Shamim MH, Dubrulle J, Johnson HL, Stossi F, Cogswell P, Sommer J, Levy J, Sharifnia T, Wawer MJ, Nabet B, Gray NS, Clemons PA, Schreiber SL, Workman P, Young RA, Lin CY
Cell Rep Med. 2021 Jan 19;2(1):100188. doi: 10.1016/j.xcrm.2020.100188. eCollection 2021 Jan 19. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
181734Phage-PGK-Flag-HA-FKBP-T(WT)for lentiviral expression of brachyury ORF in mammalian cells
181735Phage-PGK-Flag-HA-FKBP-T(G177D)for lentiviral expression of brachyury ORF in mammalian cells

Antibodies from Article