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Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer.
Lin JJ, Choudhury NJ, Yoda S, Zhu VW, Johnson TW, Sakhtemani R, Dagogo-Jack I, Digumarthy SR, Lee C, Do A, Peterson J, Prutisto-Chang K, Malik W, Hubbeling HG, Langenbucher A, Schoenfeld AJ, Falcon CJ, Temel JS, Sequist LV, Yeap BY, Lennerz JK, Shaw AT, Lawrence MS, Ou SI, Hata AN, Drilon A, Gainor JF
Clin Cancer Res. 2021 May 15;27(10):2899-2909. doi: 10.1158/1078-0432.CCR-21-0032. Epub 2021 Mar 8. PubMed Article

Plasmids from Article

ID Plasmid Purpose
183813pLenti-CD74-ROS1 nonmutantExpress CD74-ROS1 fusion (C6;R34) in mammalian cells
183814pLenti-CD74-ROS1 G2032RExpress CD74-ROS1 fusion (C6;R34) harboring ROS1 G2032R mutation in mammalian cells
183815pLenti-CD74-ROS1 L2000VExpress CD74-ROS1 fusion (C6;R34) harboring ROS1 L2000V mutation in mammalian cells
183816pLenti-CD74-ROS1 L2086FExpress CD74-ROS1 fusion (C6;R34) harboring ROS1 L2086F mutation in mammalian cells
183818pLenti-CD74-ROS1 S1986F/L2000VExpress CD74-ROS1 fusion (C6;R34) harboring ROS1 S1986F/L2000V mutation in mammalian cells
183819pLenti-CD74-ROS1 S1986F/L2086FExpress CD74-ROS1 fusion (C6;R34) harboring ROS1 S1986F/L2086F mutation in mammalian cells
183820pLenti-CD74-ROS1 G2032R/L2086FExpress CD74-ROS1 fusion (C6;R34) harboring ROS1 G2032R/L2086F mutation in mammalian cells
183821pLenti-CD74-ROS1 S1986F/G2032RExpress CD74-ROS1 fusion (C6;R34) harboring ROS1 S1986F/G2032R mutation in mammalian cells
183822pLenti-CD74-ROS1 S1986F/G2032R/L2086FExpress CD74-ROS1 fusion (C6;R34) harboring ROS1 S1986F/G2032R/L2086F mutation in mammalian cells

Antibodies from Article