CDK10 loss primes tumor cells for transcriptional vulnerability and sensitizes to CDK12/13 inhibition.
Islam S, Tarumoto Y, Takano M, Sugino S, Nishibuchi G, Mizutani A, Yamakawa H, Morishita D, Yusa K
Cell Death Dis. 2026 Jun 11;17(1):737. doi: 10.1038/s41419-026-08973-x.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 246510 | pKLV2-EF1a-neoT2AFlagStop-W | Letiviral vector to express cDNA under the control of human EF1a promoter with G418 resistant gene |
| 246511 | pKLV2-EF1a-neoT2AFlagCDK10wt-W | Lentiviral vector expressing human Flag-tagged gRNA-resistant human CDK10 |
| 246512 | pKLV2-EF1a-neoT2AFlagCDK10me3-W | Lentiviral vector expressing human Flag-tagged gRNA-resistant mutant human CDK10 (D181N) |
| 246513 | pKLV2-U6gRNA5(CDK10_v3_6-1)-PGKpuroBFP-W | Lentiviral vector expressing gCDK10_v3_6-1 |
| 246514 | pKLV2-U6gRNA5(CDK10_v3_6-3)-PGKpuroBFP-W | Lentiviral vector expressing gCDK10_v3_6-3 |
| 246515 | pKLV2-U6gRNA5(FAM58A_v3_6-1)-PGKpuroBFP-W | Lentiviral vector expressing gFAM58A_v3_6-1 |
| 246516 | pKLV2-U6gRNA5(FAM58A_v3_6-5)-PGKpuroBFP-W | Lentiviral vector expressing gFAM58A_v3_6-5 |
| 246517 | pKLV2-U6gRNA5(HNRNPA2B1_v3_6-3)-PGKpuroBFP-W | Lentiviral vector expressing gHNRNPA2B1_v3_6-3 |
| 246518 | pKLV2-U6gRNA5(HNRNPA2B1_v3_6-4)-PGKpuroBFP-W | Lentiviral vector expressing gHNRNPA2B1_v3_6-4 |
| 246519 | pKLV2-U6gRNA5(SCAF4_v3_6-1)-PGKpuroBFP-W | Lentiviral vector expressing gSCAF4_v3_6-1 |
| 246520 | pKLV2-U6gRNA5(SCAF4_v3_6-6)-PGKpuroBFP-W | Lentiviral vector expressing gSCAF4_v3_6-6 |
| 246521 | pKLV2-U6gRNA5(TTC14_v3_7-4)-PGKpuroBFP-W | Lentiviral vector expressing gTTC14_v3_7-4 |
| 246522 | pKLV2-U6gRNA5(TTC14_v3_7-5)-PGKpuroBFP-W | Lentiviral vector expressing gTTC14_v3_7-5 |