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Alexander Marson Lab: Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits

Zhu R, Dann E, Yan J, Retana JR, Goto R, Guitche RC, Petersen LK, Ota M, Pritchard JK, Marson A
bioRxiv 2025.12.23.696273 (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
251159lentiGuide-Puro-PJY390Cloning backbone for guide RNAs compatible with 10x FLEX
251161lentiGuide-Puro-P2A-EGFP-PJY392Cloning backbone for guide RNAs compatible with 10x FLEX
252529pZR316_Lenti-Ef1a-ZIM3-dCas9-2A-BsdRExpress ZIM3-dCas9 and BSD
254300CROPseq-Puro-P2A-EGFP-PJY463Cloning backbone for guide RNAs compatible with 10x FLEX and CROPseq

Antibodies from Article