Autoregulatory control of mitochondrial glutathione homeostasis.
Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, Molina H, Allwein B, Kenny TC, Possemato RL, Zhao L, Hite RK, Vinogradova EV, Mansy SS, Birsoy K
Science. 2023 Nov 17;382(6672):820-828. doi: 10.1126/science.adf4154. Epub 2023 Nov 2.
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 257536 | pMXs-3xFLAG-SLC25A39 | SLC25A39 reporter and mutant overexpression |
| 257537 | pMXs-3xFLAG-SLC25A39(delta42-106) | SLC25A39 reporter and mutant overexpression |
| 257538 | pMXs-3xFLAG-SLC25A39(delta72-86) | SLC25A39 reporter and mutant overexpression |
| 257539 | pMXs-3xFLAG-SLC25A39(C74S) | SLC25A39 reporter and mutant overexpression |
| 257540 | pMXs-3xFLAG-SLC25A39(C78S) | SLC25A39 reporter and mutant overexpression |
| 257541 | pMXs-3xFLAG-SLC25A39(C88S) | SLC25A39 reporter and mutant overexpression |
| 257542 | pMXs-3xFLAG-SLC25A39(C94S) | SLC25A39 reporter and mutant overexpression |
| 257543 | pMXs-3xFLAG-SLC25A39(C74/88S) | SLC25A39 reporter and mutant overexpression |
| 257544 | pMXs-3xFLAG-SLC25A39(C74/94S) | SLC25A39 reporter and mutant overexpression |
| 257545 | pMXs-3xFLAG-SLC25A39(C78/88S) | SLC25A39 reporter and mutant overexpression |
| 257546 | pMXs-3xFLAG-SLC25A39(C78/94S) | SLC25A39 reporter and mutant overexpression |
| 257547 | pMXs-3xFLAG-SLC25A39(C88/94S) | SLC25A39 reporter and mutant overexpression |
| 257548 | pMXs-3xFLAG-SLC25A39(C74/78/88/94S) | SLC25A39 reporter and mutant overexpression |
| 257549 | pMXs-3xFLAG-SLC25A39-P2A-RFP | SLC25A39 reporter and mutant overexpression |
| 257550 | pMXs-MitoCHAC1-blast | Depleting mitochondrial GSH |
| 257551 | pMXs-3xFLAG-SLC25A11 | SLC25A39 and SLC25A11 chimeric constructs |
| 257553 | pMXs-3xFLAG-SLC25A11(+SLC25A39aa42-106, C78/88S) | SLC25A39 and SLC25A11 chimeric constructs |
| 257554 | pMXs-3xFLAG-SLC25A11(+Anc.SLC25A39aa42-106) | SLC25A39 and SLC25A11 chimeric constructs |
| 257555 | pMXs-3xFLAG-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257556 | pMXs-3xFLAG-SLC25A39(aa42-106)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257557 | pMXs-3xFLAG-SLC25A39(aa52-106)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257558 | pMXs-3xFLAG-SLC25A39(aa62-106)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257559 | pMXs-3xFLAG-SLC25A39(aa72-106)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257560 | pMXs-3xFLAG-SLC25A39(aa82-106)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257561 | pMXs-3xFLAG-SLC25A39(aa92-106)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257562 | pMXs-3xFLAG-SLC25A39(aa42-96)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257563 | pMXs-3xFLAG-SLC25A39(aa42-86)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257564 | pMXs-3xFLAG-SLC25A39(aa42-76)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257565 | pMXs-3xFLAG-SLC25A39(aa42-66)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257566 | pMXs-3xFLAG-SLC25A39(aa42-56)-GFP-P2A-GFP-HA | SLC25A39 truncation reporter for stability |
| 257567 | pMXs-AFG3L2(E408Q)-HA-IRES-puro | AFG3L2 trapping mutation |
| 257568 | pLV-SLC25A28-blast | Encoding Mitoferrin-2 |
| 257569 | pLV-SLC25A28-puro | Encoding Mitoferrin-2 |
| 257570 | pLV-SLC25A37-blast | Encoding Mitoferrin-1 |
| 257571 | pLV-SLC25A37-puro | Encoding Mitoferrin-1 |
| 257572 | pLentiV2-Opti-sgAFG3L2.1-puro | sgRNA targeting AFG3L2 |
| 257573 | pLentiV2-Opti-sgAFG3L2.2-puro | sgRNA targeting AFG3L2 |
| 257574 | pLentiV2-Opti-sgSPG7.1-puro | sgRNA targeting SPG7 |
| 257575 | pLentiV2-Opti-sgSPG7.2-puro | sgRNA targeting SPG7 |
| 257577 | pLentiV2-Opti-sgISCU.1-puro | sgRNA targeting ISCU |
| 257578 | pLentiV2-Opti-sgISCU.2-puro | sgRNA targeting ISCU |
| 257579 | pLentiV2-Opti-sgGLRX5.1-puro | sgRNA targeting GLRX5 |
| 257580 | pLentiV2-Opti-sgGLRX5.2-puro | sgRNA targeting GLRX5 |
| 257581 | pLentiV2-Opti-sgHSCB.1-puro | sgRNA targeting HSCB |
| 257582 | pLentiV2-Opti-sgHSCB.2-puro | sgRNA targeting HSCB |
| 257583 | pLentiV2-Opti-sgABCB7.1-puro | sgRNA targeting ABCB7 |
| 257584 | pLentiV2-Opti-sgABCB7.2-puro | sgRNA targeting ABCB7 |
| 257585 | pLentiV2-Opti-sgFECH.1-puro | sgRNA targeting FECH |
| 257586 | pLentiV2-Opti-sgFECH.2-puro | sgRNA targeting FECH |
| 257587 | pLentiV2-Opti-sgNFU1.1-puro | sgRNA targeting NFU1 |
| 257588 | pLentiV2-Opti-sgNFU1.2-puro | sgRNA targeting NFU1 |
| 257589 | pLentiV2-Opti-sgCHCHD4.1-puro | sgRNA targeting CHCHD4 |
| 257590 | pLentiV2-Opti-sgCHCHD4.2-puro | sgRNA targeting CHCHD4 |
| 257591 | pLKO-shABCB7.1-puro | Expresses shRNA targeting ABCB7 |
| 257592 | pLKO-shABCB7.2-puro | Expresses shRNA targeting ABCB7 |
| 257594 | PEA1-SLC25A39(C88C) | Prime editing for SLC25A39 |
| 257595 | PEA1-SLC25A39(C88S) | Prime editing for SLC25A39 |
| 257596 | PEA1-SLC25A39(C94C) | Prime editing for SLC25A39 |
| 257597 | PEA1-SLC25A39(C94S) | Prime editing for SLC25A39 |