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The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization.
Lawe DC, Patki V, Heller-Harrison R, Lambright D, Corvera S J Biol Chem. 2000 Feb 4;275(5):3699-705.