Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.
Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8. Epub 2007 Mar 2.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 45547 | pcDNA5/FRT-HA-hM3D(Gq) | Expresses hM3D (Gq) neuronal activator |
| 45548 | pcDNA5/FRT-HA-hM4D(Gi) | Expresses hM4D (Gi) neuronal inhibitor |
| 45549 | pcDNA5/FRT-HA-rM3D(Gs) | Expresses rM3D (Gs) neuronal activator |