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Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.

Armbruster BN, Li X, Pausch MH, Herlitze S, Roth BL
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5163-8. Epub 2007 Mar 2. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
45547pcDNA5/FRT-HA-hM3D(Gq)Expresses hM3D (Gq) neuronal activator
45548pcDNA5/FRT-HA-hM4D(Gi)Expresses hM4D (Gi) neuronal inhibitor
45549pcDNA5/FRT-HA-rM3D(Gs)Expresses rM3D (Gs) neuronal activator

Antibodies from Article