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CRISPR Plasmids: Epigenetics


To make targeted epigenetic modifications, researchers have fused catalytically dead dCas9 to epigenetic modifiers. Design your gRNA to target a specific promoter or enhancer for your gene of interest.

Available modifications include:

  • histone acetylation by p300
  • histone demethylation by LSD1
  • cytosine methylation by DNMT3A or MQ1
  • cytosine demethylation by Tet1

These modifications persist over time and are potentially heritable in dividing cells. CRISPR Activate and Interfere technologies also indirectly modify local chromatin state.

CRISPR epigenetics schematic

Browse, sort, or search the tables below for CRISPR plasmids for epigenetic modification in mammalian or plant systems.

Mammalian

Plasmid Gene/Insert Promoter Selectable Marker PI Publication

Plant

Plasmid Gene/Insert Promoter Selectable Marker PI Publication


Do you have suggestions for other plasmids that should be added to this list?

Fill out our Suggest a Plasmid form or e-mail [email protected] to help us improve this resource!