We narrowed to 589 results for: hyper

1. pcDNA3.1_ADAR2DD_E488Q_Ago2

   Plasmid

   #205599

   Purpose

   expresses human ADAR2 deaminase domain (E488Q hyperactive mutant) fused with human Ago2 in mammalian cells

   Depositor

   Marc Friedlander

   Article

   Sekar et al Nat Biotechnol. 2023 Sep 21. doi: 10.103

   Insert

   hAgo2 (AGO2 Human)
   

   Tags

   ADAR2DD_E488Q (hyperactive mutant)

   Expression

   Mammalian

   Available Since

   Oct. 2, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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2. scADGFP

   Plasmid

   #114434

   Purpose

   Epilepsy promoter enhanced with Arc elements driving GFP with SV40E polyA

   Depositor

   Edward Perez-Reyes

   Article

   Burke et al Int J Mol Sci. 2023 Sep 23;24(19):14467.

   Insert

   Green fluorescent protein
   

   Use

   AAV

   Tags

   ER export sequence FCYENEV

   Expression

   Mammalian

   Promoter

   Novel synthetic activity-dependent promoter

   Available Since

   Sept. 25, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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3. pcDNA3-FLAG-MTOR-L1460P

   Plasmid

   #69006

   Purpose

   activating MTOR mutation

   Depositor

   David Sabatini

   Article

   Grabiner et al Cancer Discov. 2014 May;4(5):554-63. doi

   Insert

   MTOR-L1460P (MTOR Human)
   

   Tags

   FLAG

   Expression

   Mammalian

   Mutation

   change Leucine 1460 to Proline

   Available Since

   Dec. 17, 2015

   Availability

   Academic Institutions and Nonprofits only

   

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4. pD21-AI-hLDLR

   Plasmid

   #124964

   Purpose

   Express human LDLR under human APOAI promoter

   Depositor

   Kazuhiro Oka

   Article

   Li et al J Genet Syndr Gene Ther. 2011 Sep 28;2:1

   Insert

   human LDLR (LDLR Human)
   

   Use

   Adenoviral

   Promoter

   human APOAI

   Available Since

   Nov. 19, 2019

   Availability

   Academic Institutions and Nonprofits only

   

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5. pRK5-HA-GST-4EBP1-Low GC

   Plasmid

   #69018

   Purpose

   expresses tagged 4EBP1

   Depositor

   David Sabatini

   Article

   Grabiner et al Cancer Discov. 2014 May;4(5):554-63. doi

   Insert

   EIF4EBP1 (EIF4EBP1 Human)
   

   Tags

   GST and HA

   Expression

   Mammalian

   Mutation

   lowGC content, wt is ~70% GC rich. Still, it code…

   Available Since

   Jan. 2, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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6. pRhobin2-SEC61B-IRES-NLS-mTagBFP-2xNLS

   Plasmid

   #239024

   Purpose

   Co-overexpression of Rhobin2-SEC61B fusion protein and NLS-mTagBFP-2xNLS as a nuclear labeling marker

   Depositor

   William DeGrado, Bo Huang

   Article

   Chen et al bioRxiv 2025.06.24.661379

   Insert

   Rhobin2-SEC61B (SEC61B Synthetic, Human)
   

   Tags

   TagBFP

   Expression

   Mammalian

   Promoter

   CMV promoter

   Available Since

   June 26, 2025

   Availability

   Academic Institutions and Nonprofits only

   

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7. CaV1.3e[8a,11,31b,Δ32,42a]

   Plasmid

   #49333

   Purpose

   Repaired Addgene #26576 to agree with the rat ref sequence. Repairs are @: nt 3310 (GTG->GCG) [Val->Ala]; nt 731 (TCA->GGA) [Ser->Gly].

   Depositor

   Diane Lipscombe

   Article

   Xu et al J Neurosci. 2001 Aug 15. 21(16):5944-51.

   Insert

   CACNA1D (Cacna1d Rat)
   

   Expression

   Mammalian

   Mutation

   Contains exons 8a, 11, 31b and 42a.Deletion of ex…

   Promoter

   CMV

   Available Since

   Feb. 14, 2014

   Availability

   Academic Institutions and Nonprofits only

   

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8. pcDNA3-FLAG-MTOR-C1483F

   Plasmid

   #69008

   Purpose

   activating MTOR mutation

   Depositor

   David Sabatini

   Article

   Grabiner et al Cancer Discov. 2014 May;4(5):554-63. doi

   Insert

   MTOR-C1483F (MTOR Human)
   

   Tags

   FLAG

   Expression

   Mammalian

   Mutation

   change Cysteine 1483 to Phenylalanine

   Available Since

   Jan. 26, 2016

   Availability

   Academic Institutions and Nonprofits only

9. MSI2-DCD

   Plasmid

   #166968

   Purpose

   Express the fusion protein of human MSI2 and the catalytic dead domain of Drosophila ADAR

   Depositor

   Michael Kharas

   Article

   Nguyen et al Nat Commun. 2020 Apr 24;11(1):2026. doi:

   Insert

   MSI2-DCD
   

   Use

   Retroviral

   Tags

   MSI2-DCD

   Expression

   Mammalian

   Mutation

   N495S

   Promoter

   MSCV

   Available Since

   March 18, 2021

   Availability

   Academic Institutions and Nonprofits only

   

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10. pLKO.1P CISD1_1

    Plasmid

    #160773

    Purpose

    Suppress CISD1

    Depositor

    Richard Possemato

    Article

    Sviderskiy et al Mol Cell. 2020 Oct 28. pii: S1097-2765(2

    Insert

    shCISD1_1
    

    Use

    Lentiviral

    Available Since

    Oct. 29, 2020

    Availability

    Academic Institutions and Nonprofits only

    

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11. pLKO.1P CISD1_2

    Plasmid

    #160774

    Purpose

    Suppress CISD1

    Depositor

    Richard Possemato

    Article

    Sviderskiy et al Mol Cell. 2020 Oct 28. pii: S1097-2765(2

    Insert

    shCISD1_2
    

    Use

    Lentiviral

    Available Since

    Oct. 29, 2020

    Availability

    Academic Institutions and Nonprofits only

    

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12. Pinducer20-BSD-scFv-sfGFP-DNMT3A1

    Plasmid

    #115780

    Purpose

    targeted DNA methylation tool

    Depositor

    Margaret Goodell

    Article

    Su et al Genome Biol. 2018 Aug 10;19(1):108. doi:

    Insert

    scFv-sfGFP-DNMT3A1 (DNMT3A Human)
    

    Expression

    Mammalian

    Promoter

    TRE

    Available Since

    Oct. 11, 2018

    Availability

    Academic Institutions and Nonprofits only

    

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13. MYH11-gRNA1

    Plasmid

    #132587

    Purpose

    gRNA used for knockin NanoLuc and tdTomado (separated by 2A) into MYH11 allele (MYH11-NanoLuc-2A-tdTomato vector) )

    Depositor

    James Thomson

    Article

    Zhang et al Stem Cell Reports. 2019 Jun 11;12(6):126

    Insert

    MYH11-gRNA1
    

    Expression

    Bacterial

    Available Since

    Oct. 8, 2019

    Availability

    Academic Institutions and Nonprofits only

    

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14. pLB038 - PHS1∆P

    Plasmid

    #136285

    Purpose

    entry vector for GreenGate cloning method, C module, open reading frame of phosphatase-inactive PROPYZAMIDE-HYPERSENSITIVE 1 (PHS1) (PHS1DP)

    Depositor

    Alexis Maizel

    Article

    Vilches Barro et al Curr Biol. 2019 Aug 5;29(15):2443-2454.e

    Insert

    PHS1∆P
    

    Expression

    Bacterial

    Available Since

    Feb. 3, 2020

    Availability

    Academic Institutions and Nonprofits only

    

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15. pcDNA3-FLAG-MTOR-T1977R

    Plasmid

    #69011

    Purpose

    activating MTOR mutation

    Depositor

    David Sabatini

    Article

    Grabiner et al Cancer Discov. 2014 May;4(5):554-63. doi

    Insert

    MTOR-T1977R (MTOR Human)
    

    Tags

    FLAG

    Expression

    Mammalian

    Mutation

    change Threonine 1977 to Arginine

    Available Since

    Dec. 15, 2015

    Availability

    Academic Institutions and Nonprofits only

16. pcDNA3-FLAG-MTOR-F1888L

    Plasmid

    #69010

    Purpose

    activating MTOR mutation

    Depositor

    David Sabatini

    Article

    Grabiner et al Cancer Discov. 2014 May;4(5):554-63. doi

    Insert

    MTOR-F1888L (MTOR Human)
    

    Tags

    FLAG

    Expression

    Mammalian

    Mutation

    change Phenylalanine 1888 to Leucine

    Available Since

    Jan. 20, 2016

    Availability

    Academic Institutions and Nonprofits only

17. pLKO.1P POLE1_1

    Plasmid

    #160762

    Purpose

    Suppress POLE1

    Depositor

    Richard Possemato

    Article

    Sviderskiy et al Mol Cell. 2020 Oct 28. pii: S1097-2765(2

    Insert

    shPOLE1_1
    

    Use

    Lentiviral

    Available Since

    Oct. 28, 2020

    Availability

    Academic Institutions and Nonprofits only

    

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18. pD21-hgAPOAI

    Plasmid

    #124962

    Purpose

    Express ApoAI in the liver

    Depositor

    Kazuhiro Oka

    Article

    Belalcazar et al Circulation. 2003 Jun 3;107(21):2726-32.

    Insert

    human APOAI gene (LPA Human)
    

    Use

    Adenoviral

    Promoter

    human APOAI

    Available Since

    July 19, 2019

    Availability

    Academic Institutions and Nonprofits only

    

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19. pLKO.1P POLD1_2

    Plasmid

    #160792

    Purpose

    Suppress POLD1

    Depositor

    Richard Possemato

    Article

    Sviderskiy et al Mol Cell. 2020 Oct 28. pii: S1097-2765(2

    Insert

    shPOLD1_2
    

    Use

    Lentiviral

    Available Since

    Oct. 29, 2020

    Availability

    Academic Institutions and Nonprofits only

    

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20. pLKO.1P POLE1_2

    Plasmid

    #160764

    Purpose

    Suppress POLE1

    Depositor

    Richard Possemato

    Article

    Sviderskiy et al Mol Cell. 2020 Oct 28. pii: S1097-2765(2

    Insert

    shPOLE1_2
    

    Use

    Lentiviral

    Available Since

    Jan. 20, 2021

    Availability

    Academic Institutions and Nonprofits only

    

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