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pAAVS1-NDi-CRISPRi (Gen2)

Plasmid

#73498

Purpose

Dox-inducible CRISPR interference (CRISPRi) knock in construct into the AAVS1 locus

Depositor

Bruce Conklin

Article

Mandegar et al Cell Stem Cell. 2016 Apr 7;18(4):541-53.

Inserts

dCas9-KRAB
rtTA

Use

CRISPR

Tags

HA, KRAB, and NLS

Expression

Mammalian

Mutation

D10A, H840A (catalytically deactivated Cas9)

Promoter

CAG and TRE3G

Available Since

Dec. 7, 2016

Availability

Academic Institutions and Nonprofits only

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pET-NLS-Cas9-6xHis

Plasmid

#62934

Purpose

Expression of NLS-Cas9-6xHis in bacterial cells

Depositor

David Liu

Article

Zuris et al Nat Biotechnol. 2015 Jan;33(1):73-80. do

Insert

NLS-Cas9-6xHis

Tags

6xHis tag and NLS

Expression

Bacterial

Promoter

T7

Available Since

May 11, 2015

Availability

Academic Institutions and Nonprofits only

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pMS77

Plasmid

#215681

Purpose

Cas9 + guide plasmid targeting ChrIII split hygromycinR landing pad

Depositor

Patrick Phillips

Article

Moerdyk-Schauwecker et al MicroPubl Biol. 2024 Jan 29;2024:10.1791

Insert

eef-1A.1p::Cas9 + U6p::GTCCAGCGGCAGATCGGCGG

Use

CRISPR

Expression

Worm

Available Since

March 21, 2024

Availability

Academic Institutions and Nonprofits only

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pLenti6.3 GCN1-3xFlag_IRES-iRFP

Plasmid

#198388

Purpose

GCN1 expression

Depositor

Jack Taunton

Article

Oltion et al Cell. 2023 Jan 19;186(2):346-362.e17. do

Insert

GCN1 (GCN1 Human)

Use

Lentiviral

Tags

3xFlag

Expression

Mammalian

Promoter

CMV

Available Since

June 27, 2023

Availability

Academic Institutions and Nonprofits only

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PiggyBac CAG eGFP-PolQ-FLAG P2A-BLAST

Plasmid

#249811

Purpose

Expresses the PolQ (polymerase theta) protein fused with N-terminal eGFP and C-terminal FLAG tag

Depositor

Raphael Ceccaldi

Article

Gelot et al Nature. 2023 Sep;621(7978):415-422. doi:

Insert

Polymerase Theta (POLQ Human)

Tags

FLAG and eGFP

Expression

Mammalian

Promoter

CAG

Available Since

March 6, 2026

Availability

Academic Institutions and Nonprofits only

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MEK1-DD-V5

Plasmid

#217298

Purpose

Lentivirus vector for expression of MEK1 S218D/S222D

Depositor

Channing Der

Insert

MAP2K1 (MAP2K1 Human)

Use

Lentiviral

Tags

V5

Mutation

S218D/S222D

Available Since

July 31, 2024

Availability

Academic Institutions and Nonprofits only

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pNatB (pACYCduet-naa20-naa25)

Plasmid

#53613

Purpose

Allows expression of the fission yeast NatB complex - chloramphenicol marker

Depositor

Dan Mulvihill

Article

Johnson et al PLoS One. 2010 Dec 23;5(12):e15801. doi:

Inserts

naa20 (naa20 Fission Yeast)
naa25 (naa25 Fission Yeast)

Expression

Bacterial

Promoter

T7

Available Since

June 20, 2014

Availability

Academic Institutions and Nonprofits only

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AiP14945 - pAAV-AiE0410m-minBG-iCre(R297T)-3XmiR126TS-BGHpA

Plasmid

#254824

Purpose

Encodes an AAV that expresses Cre specifically in oligodendrocytes

Depositor

Allen Institute for Brain Science, Boaz Levi, Jonathan Ting

Article

Mich et al eLife 14:RP108640

Insert

iCre

Use

AAV

Mutation

R297T for less recombinase activity which yields …

Available Since

May 20, 2026

Availability

Academic Institutions and Nonprofits only

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pIVT-p53DD

Plasmid

#232751

Purpose

IVT template for making modRNA encoding p53DD, a mutant p53 that lacks DNA binding ability

Depositor

Kate Galloway

Article

Blanch-Asensio et al Nat Biomed Eng. 2026 Apr 30. doi: 10.103

Insert

p53DD

Use

In vitro transcription

Mutation

deletion of DNA binding domain

Available Since

March 17, 2025

Availability

Academic Institutions and Nonprofits only

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AsCas12a-6xNLS-E174R/S542R (pRG232)

Plasmid

#149723

Purpose

Lentiviral expression plasmid of AsCas12a-6xNLS-E174R/S542R with puromycin resistance gene

Depositor

Junwei Shi

Article

Gier et al Nat Commun. 2020 Jul 13;11(1):3455. doi:

Type

Empty backbone

Use

CRISPR and Lentiviral

Expression

Mammalian

Promoter

EFS

Available Since

June 3, 2020

Availability

Academic Institutions and Nonprofits only

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