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We narrowed to 943 results for: Arch

Showing: 381 - 400 of 943 results
  1. Avoiding the Dark Side of Fluorescent Protein Fusions with mOX FPs

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    Blog Post
    ... in Biomedical Research from Albert Einstein College of Medicine. Her doctoral research was conducted ...Figure 1). When behaving properly, FPs enable researchers to investigate the localization and dynamics ...co-mentorship Blossom Damania and Jack Griffith, her research focuses on the replication machinery of Kaposi...secretory pathway."Biochemical and biophysical research communications 430.3 (2013): 1114-1119. Pubmed...
  2. mTOR Pathway

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    Collection
    ... Cancer Research mTOR Pathway mTOR Pathway You May Also Like: Cancer...
  3. The Advances Behind The World's First Personalized CRISPR Treatment

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    Blog Post
    ...transplant — creating intense time pressure for the research team. Ultimately, the lifesaving effort was only...possible because of a massive collaboration between research hospitals, universities, private companies, and...invention of base editing doesn’t necessarily mean researchers can fix any problematic C or A mutations in the...higher risk of off-target editing and longer genome search times. Using a machine learning approach, the lab...of a collaborative community focused on CRISPR research, and we’re grateful for every scientist who uses...
  4. Multicolor Animals: Using Fluorescent Proteins to Understand Single Cell Behavior

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    Blog Post
    ...exist for a variety of species, cell types, and research applications. Labeling neurons with Brainbow The... used alongside common, existing tools for fly research that use Flp recombination. In addition to the...small population size of CFP++ cells permitted researchers to longitudinally map the turnover of Langerhans...such as the brain, transparent so that the 3D architecture of a fluorescent neuron is visible. Chemical...more details, check out this blog post from the researchers who developed Tetbow. Conclusion Stochastic multicolor...
  5. CRISPR 101: Epigenetics and Editing the Epigenome

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    Blog Post
    ...expression or silencing. To alter DNA modifications, researchers used blunt tools like histone deacetylases, but...epigenetic modifications at a user-specified locus. Researchers showed that TALE-TET1 constructs, which fused...transcription at CpG regions of various promoters. Other researchers additionally fused a TAL effector to LSD1 histone...and dCas9-based epigenome editing. Nucleic Acids Research 47:e23–e23. https://doi.org/10.1093/nar/gky1286...system for targeted DNA methylation. Nucleic Acids Research 44:5615–5628 . https://doi.org/10.1093/nar/gkw159...
  6. PiggyBac-ing Through the Genome Editing Field

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    Blog Post
    ... selection marker such as thymidine kinase, a researcher may subsequently kill off any cells that still...later restores the target sequence. This allows researchers to avoid making unnecessary base pair changes...powerful technology that may be used for a variety of research applications, including making transgenic cell...molecular and cellular biology and brings 10 years of research experience with stem cells to Transposagen's cell...Mathew applies his specialized knowledge to help researchers identify the right technologies and strategies...
  7. Introducing Addgene's Microbiology Pages

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    Blog Post
    ...on the right-hand side of the search page to narrow your keyword search to one of these organisms. Help...plasmid kits and other resources for microbial research. Kits, guides, plasmids, and more We have Plasmid...resources that we created filters just for them on our search page. Use the Expression and Insert Species filters...
  8. Plasmid Grant to Aid Cervical Cancer Screening in Ghana

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    Blog Post
    ...continuation of our efforts to provide resources to researchers in developing countries or that work in under-funded...continued opportunity to get plasmids to the researchers who need them the most. Check back here to learn...more about future awardees and their inspiring research. Additional Resources on the Addgene Blog Learn...Resources Learn About Our Grants to Rare Disease Research Resources on Addgene.org Check out our Cancer...
  9. Celebrating One Million Plasmids Shared!

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    Blog Post
    ... us to calculate how much time we have saved researchers. In a recent blog post, we looked at how long... plasmid and how much time Addgene has saved researchers. Assuming 5 hours of hands-on time to make each...are always on the lookout for new ways to help researchers facilitate and accelerate scientific discovery...discovery. How can Addgene help accelerate your research? Let us know! ...
  10. Addgene’s Blog Gets a New Look!

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    Blog Post
    ...you’re new to the topic. Or, try the search bar Now, you can search for the articles you want to find without...on the search bar at the top of the screen and type in what you’re looking for. After you search, you’ll...
  11. Antibodies 101: Validation

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    Blog Post
    ...important. Antibodies are a critical component of the researcher toolkit due to their ability to bind to molecular...culprits in the reproducibility crisis of biomedical research (Baker, 2015; Bradbury & Plükthorn, 2015).  To...which represent five experimental strategies researchers can use to show that their antibody performs ...Reproducibility: Standardize antibodies used in research. Nature 518:27–9. https://doi.org/10.1038/518027a...finding and validating suitable antibodies for research. Mabs 8:27–36. https://doi.org/10.1080/19420862.2015.1100787...
  12. Your Top Requested Plasmid in 2015!

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    Blog Post
    ... and cloned by Neville Sanjana. This fantastic research tool has been requested from the repository nearly...over a year and a half, a small sampling of the research it has already been used for includes work probing...plasmids being distributed to and accelerating research in labs all around the world. We thank our many...depositors for making these reagents available to the research community through Addgene and look forward to ...
  13. More Data for You: Find Articles Citing Addgene Plasmids

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    Blog Post
    ...You can also use the "Search Table" box at the upper right of the table to search and filter the list of...here to explore the TetO-FUW-OKSM plasmid page. Or search for your favorite plasmids and see where they've...the article that has used this plasmid. Happy researching! If you need any assistance finding plasmids ...
  14. p53 Pathway

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    Collection
    ... Cancer Research p53 Pathway p53 Pathway You May Also Like: Cancer...
  15. Fluorescent Proteins 101: History of Fluorescent Proteins

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    Blog Post
    ...fluorescent proteins like GFP came to be used as research tools is particularly interesting. Although humans...light and glows green. In the late 1980s, another researcher, Douglas Prasher, got the idea that this new ...of GFP, and began to realize its potential as a research tool. Soon, the number of people studying it grew...proteins with new colors Around the same time, researcher Sergey Lukyanov realized that, although they ...
  16. Why Do I Need an MTA Anyway?

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    Blog Post
    ...Permission to use materials for research or teaching purposes Rights to all research results, modifications,...understand - you’re a busy scientist working hard on research, and you need the right experimental materials... receiving institutions and their respective researchers. Check out the lists below for more details. ...
  17. Celebrating Accomplishments in the Lab

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    Blog Post
    ...Choosing a Research Project Finding and Joining Your Dream Lab Advice for Choosing a Research Project Advice... to build and lead a productive and successful research lab. Once goals are reached, how do science labs...day trip each year and as we do a lot of yeast research, a few of those have been trips to breweries who...
  18. 2023 and 2024: Reflections and Looking Ahead

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    Blog Post
    ...goals of accelerating research and discovery by improving access to useful research materials and information...impact made possible by the sharing of tools for research: discovered and developed by our depositors, used...ways to support a global community where every researcher feels both welcomed and resourced for success...
  19. CRISPR 101: Cytosine Transversion Editors

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    Blog Post
    ...story of base transversion editors starts with researchers in the Keith Joung lab, who were engineering ...editing between bacteria and mammalian cells Researchers in the Xueli Zhang lab were making similar observations...develop more efficient and precise editors. Most researchers agreed on the first part of the likely editing... efficacy varied among target sequences. The researchers hypothesized that the CGBE edit process occurs...experimented with adding different proteins to the CGBE architecture. They conducted a CRISPRi screen to identify...
Showing: 381 - 400 of 943 results