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We describe the different modular cloning kits available for different applications and organisms to help you find the kit that's right for your experiment.

Baby KJ was treated for his devastating genetic disorder with CRISPR base editing. This post describes the prior advances that made his cure possible.

Cpf1, a newly discovered Cas9 homolog, is smaller than Cas9, can target different sequences, and may more efficiently generate targeted mutations.

Browse Addgene's collection of plasmids for the generation and study of stem cells, from iPSC generation to directed differentiation.

Yeast genome modification plasmids have been developed for tagging yeast genes with fluorescent proteins, epitope tags, and more. Various systems are described to help you choose which to use for your research.

Learn how site specific recombinases like Cre-lox and FLP-FRT can be combined for complex control over gene expression in neuroscience experiments and more.

Learn about the process to select the optimal serotype, promoter, and titer for your AAV experiment.

Addgene's microbiology resources: Find plasmids for your microbe of interest, including bacteria, viruses, protozoa, fungi, and more.

Curious about systemic capsids? Looking for one to test in your experimental system? This 101 is an introduction to systemic capsids uses and types!

Ready to let your tags do the work for you? Learn about self-labelling protein tags and how they can give you flexibility in your experimental approach!

Learn about evaluating DNA quality with Spectophotometry using a Nanodrop

Prime editing is a search-and-replace CRISPR editing method that offers versatility and precision in genome editing. We cover common prime editing tools.

Curious about the history of C-myc, one of the most common antibody tags? Learn all about it here!

Learn how you can use HDR and CRISPR to make a knock-in cell line for your research.

We describe the different classes of optogenetic tools available and what levels of control they give you in your experimental setup.

Fourteen years after Cas9, CRISPR has moved beyond DNA cutting. Read Addgene's recap of CRISPR Frontiers 2026, covering programmable gene insertion, RNA-sensing cell killing, and next-gen base and prime editors.

An overview of cytosine and adenine base transition editors, which make precise changes in DNA bases without causing double-strand breaks.

The Allen Institute for Cell Science has deposited plasmids to generate fluorescently tagged proteins of key cellular structures in human cell lines.

Learn what non-model organisms are, why scientists use them, and what they can teach us.

Learn about the advantages of using AAV as a delivery method for CRISPR screens.