We narrowed to 3 results for: BE4max

1. CRISPR 101: Cytosine and Adenine Base Editors

   Type

   Blog Post

   Published

   Feb. 13, 2025, 2:15 p.m.

   ...localization signals and codon usage BE4 to create BE4max and AncBE4max with a 4.2-6-fold improvement in editing...adenine base editing When the Liu lab created BE4max and AncBE4max mentioned above, they also made an adenine...decreases indel frequency. Koblan et al., 2018 BE4max, ArcBe4max, ABEmax   Improved nuclear localization and... more flexible sequence preferences, evoAPOBEC1-BE4max, which is significantly more effective at editing...off-target editing Thuronyi et al., 2019 evoAPOBEC1-BE4max   Improved editing of Cs preceded by Gs Richter...SpRY Cas9, available fused to ABEmax(7.10) or to BE4max   Evolved SpCas9 with NRN or NYN PAM site Chen...

2. What's New in CRISPR - March 2020

   Type

   Blog Post

   Published

   March 10, 2020, 1:15 p.m.

   ...deamination. They generated these editors using the BE4max architecture. The new editors reported in this ...average on-target DNA-editing levels relative to BE4max.  Read the paper in Nature Biotechnology Find ...

3. CRISPR 101: Cytosine Transversion Editors

   Type

   Blog Post

   Published

   March 25, 2025, 1:15 p.m.

   ...UNG) from E. coli. The resulting construct, eUNG-BE4max(R33A)ΔUGI, was given the pithier name CGBE1, for....2% of studied sequences) (Huang et al., 2024). BE4max, a CBE, generated similar deletions at a lower ...