New Optogenetic Tools for Cytoskeleton and Membrane Control
Type
Blog Post
Published
Sept. 28, 2023, 1:15 p.m.
...). These Opto-RhoGEFs provide a reversible and non-invasive way to activate a RhoGTPase by recruiting ...
Figure 2: Opto-RhoGEFs to control Rho GTPase activity. A) Schematic of Opto-RhoGEF design and activity...useful for a wide variety of experiments.
Opto-RhoGEFs manipulate cell morphology and adhesion
But what...GTPase/GEF pair (Ridley, 2016). Taking control of a RhoGEF is a great way to stimulate and study these physical...optogenetic switches for the GEFs ITSN1, TIAM1, or p63RhoGEF (which activate the Rho GTPases Cdc42, Rac1, and...4.0 license.
Mahlandt et al. used these Opto-RhoGEFs to study cell junction integrity in the vascular... processes in cells and tissues. And, this Opto-RhoGEF design could be extended to other GTPases.
The ...