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We narrowed to 529 results for: ARL

Showing: 241 - 260 of 529 results
  1. Transferable Skills Guide: Time Management

    Type
    Blog Post
    Published
    Dec. 5, 2017, 1:52 p.m.
    ...how much time you can possibly handle doing a particularly annoying task and then dedicating that much ...dinner plans at 6 pm, you had better get started early enough to finish everything you need to do by 6 ...
  2. SARS-CoV-2/COVID-19 Detection Methods Based on CRISPR/Cas

    Type
    Blog Post
    Published
    May 5, 2020, 1:15 p.m.
    ...distancing. With countries like South Korea, one of the earlier epicenters of the outbreak ultimately flattening... is a one-pot, one-temperature reaction, and is nearly single-molecule sensitive. In the case of HIV-1...
  3. Filming Science Videos in the Age of Social Distancing

    Type
    Blog Post
    Published
    May 20, 2021, 1:15 p.m.
    ...other videos. For starters, I hadn’t anticipated nearly every webcam recording only 1280x720 resolution... to labs that need them. The lab re-opened very early in the pandemic with some incredibly strict safety...
  4. Fluorescent Proteins 101: When GFP lets you down

    Type
    Blog Post
    Published
    Aug. 23, 2018, 12:05 p.m.
    ...the use of bright red fluorescent proteins (e.g. mScarlet) or infrared fluorescent proteins (Chernov et ...interfere with the function of the protein. This is clearly the case when proteins undergo post-translational...
  5. Five Popular Model Organisms, Part 2

    Type
    Blog Post
    Published
    Sept. 29, 2020, 1:15 p.m.
    ...conducted a large scale sequencing and concluded that nearly all disease-linked human genes have counterparts...the most popular model amphibians in science with early research providing insight into some of the most...
  6. 3 Tips to Improve HDR Efficiency for CRISPR Editing in Human Cells

    Type
    Blog Post
    Published
    Sept. 5, 2017, 1:58 p.m.
    ... undergoing two rounds of gene-editing enables scarless introduction of an intended mutation while taking...4. Kwart, Dylan, et al. "Precise and efficient scarless genome editing in stem cells using CORRECT." Nature...
  7. Site Directed Mutagenesis by PCR

    Type
    Blog Post
    Published
    Aug. 2, 2016, 2:30 p.m.
    ...into the parental plasmid (or other). This is particularly relevant in cases where a large plasmid with...introduce a point mutation in a large construct. Particularly, if a pair of unique restriction site is located...
  8. Using Phosphoserine to Study Protein Phosphorylation

    Type
    Blog Post
    Published
    June 23, 2016, 2:30 p.m.
    ...using the same expression plasmid. This is a particularly important control when creating a phosphoserine-incorporation...Institute for Research in Madison, Wisconsin. She is particularly interested in the intersection of cell signaling...
  9. Evolution of Lab Techniques

    Type
    Blog Post
    Published
    June 21, 2016, 2:30 p.m.
    ...cars become more technologically advanced leaving earlier versions obsolete, the techniques we use in lab...researchers at a time when sequencing was still in the early days of development. Today, researchers use both...
  10. How to Negotiate a Successful Lab Start Up Budget

    Type
    Blog Post
    Published
    Sept. 1, 2015, 2:30 p.m.
    ...this way, if you know what you need. Most often, early career scientists aren’t trained to have these types...based on financial values. All too often, we see early investigators making unnecessary short term sacrifices...
  11. Exploring Applications of the Bioluminescent HiBiT Tag

    Type
    Blog Post
    Published
    Oct. 2, 2025, 1:15 p.m.
    ... R175H mutation to match a frequent mutation in early-onset GC and one with a mutation at R273H to match...Distinct TP53 Mutation Site-Linked Chemosensitivity in Early- and Late-Onset Gastric Cancer. Cancer Medicine,...
  12. CRISPR 101: Off-Target Effects

    Type
    Blog Post
    Published
    Feb. 8, 2024, 2:15 p.m.
    ...unanticipated sites. While off-target effects are nearly impossible to eliminate, it’s essential to understand...appropriate method for an activator or repressor Cas. Similarly, Cas ChIP-Seq would also identify all DNA binding...
  13. Viral Vectors 101: AAV Variables That Matter

    Type
    Blog Post
    Published
    June 1, 2023, 1:15 p.m.
    ...different system (Issa et al., 2023). This can be particularly burdensome in the brain where many different...such as chicken-beta-actin or CAG can drive strong early gene expression, but can become methylated over ...
  14. Generating Mouse Models Using CRISPR/Cas9

    Type
    Blog Post
    Published
    July 12, 2016, 2:30 p.m.
    ...specific changes into the mouse genome. With these early technologies, a researcher would first introduce... is a molecular biologist with Biogen and is particularly interested in applying CRISPR for mouse genome...
  15. A History of Genome Engineering in Popular Culture

    Type
    Blog Post
    Published
    Feb. 25, 2020, 2:15 p.m.
    ...to recognize DNA sequences is not ideal. For the early generation gene editors, new amino acid recognition...engineering of novel base editor proteins. She is particularly interested in combining the realms of art and...
  16. Antibodies 101: Validation

    Type
    Blog Post
    Published
    March 24, 2022, 1:15 p.m.
    ... does not mean that is all it will bind to - particularly when you start using complex samples such as... the antibody webpages. These outlets can be particularly useful for sharing negative data. Negative data...
  17. A Guide to Getting Started in Undergrad Research

    Type
    Blog Post
    Published
    June 8, 2021, 1:15 p.m.
    ...waivers. One of the blog posts that helped me quite early on was Christine Liu’s “How to Become a Scientist...on the Addgene blog Check out our resources for early career researchers Get advice for applying for jobs...
  18. How to Design Your gRNA for CRISPR Genome Editing

    Type
    Blog Post
    Published
    Sept. 24, 2020, 1:15 p.m.
    ...requires a nearby PAM, although these are still early days for this technology, and the user may need ... P-Y, Daley G, Church G (2013) Optimization of scarless human stem cell genome editing. Nucleic Acids ...
  19. Plasmids 101: Modular Cloning Applications and Kits

    Type
    Blog Post
    Published
    May 14, 2024, 1:15 p.m.
    ...bacteria or cell-free systems. The approach is particularly useful for producing drug precursors, biofuels...works in both mammalian systems and Drosophila. Similarly, the Multi-Kingdom (MK) Golden Gate system was...
Showing: 241 - 260 of 529 results