We narrowed to 222 results for: Mac

...disease front. Viruses survive by hijacking the machinery of the cells they infect. Once they enter a cell...delivered to the cell. The cell then uses its own machinery to replicate the viral genome and proteins. This...

...studies showed that iTOP functions through macropinocytosis. D’Astolfo et al. tested iTOP in a series...Protein Delivery Techniques: Introduction of macromolecules into cultured mammalian cells by osmotic lysis...

... our purposes? In search of simple biological machines R bodies can repeatedly extend and contract...using R bodies: simple, force-generating protein machines that can extend and retract over many microns ...

... which is then read by a detector panel in the machine. Fluorophores are light sensitive, so antibodies...idea to make sure that laser is available in your machine before you make your purchase. Picking a single...

...recombineering, bacteria express phage recombination machinery, which facilitates easy genetic modification by...electrocompetent cells in which the phage recombination machinery is induced using L-arabinose. These cells can ...

...instead use a preexisting, conserved cellular machinery to process gRNAs. Hijacking tRNA processing to...plants. Yang was intrigued by the tRNA processing machinery present in almost every living organism. Precursor...

...that trigger the activation of dendritic cells, macrophages, T cells, and the recruitment of neutrophils....understand so that we could possibly develop pharmaceutical interventions that would inhibit IL-36 release...

...unless autophagy is induced. Then non-selective macroautophagy of the cytosol leads to accumulation of Pho8Δ60.... E. (2015). Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single...

...proteins assemble into functional multi-subunit macromolecular complexes, but a serendipitous discovery led... amino acid. Clearly, the development of a pharmacological intervention that rescues the function of even...

... activity. They interact with transcriptional machinery to modify local gene expression, confounding any...genome and directly interacting with transcription machinery.   Well, I’ve got some good news: complete...

...Guided by dCas9, VP64 recruits transcriptional machinery to specific sequences, causing targeted gene regulation...of interest, this allows more transcriptional machinery to be recruited per targeted gene. Performance...

...were active in mouse retinas were injected into macaques and postmortem human retinas. About 25% of these... library for retinal cell expression in mouse, macaque, and man. Lab Anim 48, 264 (2019). https://doi....

... in order to turn Twitter into a paper-finding-machine. There are four general types of accounts you can...Scholar analyzes publications and figures using machine learning to extract important features such as ...

...inherited the genomic edit but not the editing machinery. Together, these advances have the potential to.... Example applications include large-scale pharmacological profiling or interrogation of context-dependent...

...partially because they contain some of the necessary machinery to make these viruses. The cells are also easy...they require cloning specific AAV or lentiviral machinery into a baculovirus plasmid. Production of baculovirus...

...Kusumika (Kushi) Mukherjee, editor of Trends in Pharmacological Sciences, a Cell Press reviews journal. Stem...Kushi) Mukherjee is the Editor of Trends in Pharmacological Sciences, a Cell Press reviews journal. She...

...range of proteins including antibodies and pharmaceuticals, specifically interleukins. Yeast expression...components of the transcription and translation machinery. These include ribosomes, RNA polymerase, tRNAs...

...for in vivo delivery of advanced genome editing machinery such as CRISPR-Cas. Figure 1: Schematic...transduced to target cells. Within target cells, Cas9 machinery is transiently expressed and binds to target DNA...

...to run larger panels: five laser spectral flow machines have 64 detectors, allowing for the use of up ...be distinguished using spectral flow since the machine uses the full spectral signature, not just a narrow...

...-colored protein from the jellyfish Cassiopea xamachana (Blanquet and Phelan, 1987). Eight years later...protein from the mangrove jellyfish Cassiopea xamachana. Marine Biology 94:423–430 . https://doi.org/10.1007...

...behavior of cancer cells, attacking the cellular machinery necessary for division. This approach also kills...variety of cancers, Ras proteins have stumped the pharmaceutical industry for years. They have proven very difficult...

...that you use the same solution for blanking your machine!  Finally, many NanoDrop systems now provide full-spectrum...are no substitute for sound techniques, routine machine maintenance, and critical interpretation of the...

...Edelhoch method. Int J Biol Macromol. 2015;77:260-5. doi: 10.1016/j.ijbiomac.2015.03.027. Epub 2015 Mar...

...RNA that bind to a cell’s DNA, telling the Cas machinery where to cut.      Fig. 2: Heatmap indicating...): 250-252. Carlson J, Henn BM, Al-Hindi DR, Ramachandran S. Counter the weaponization of genetics research...

...Ph.D. candidate at MIT. His research uses applied machine learning and statistical methods for fundamental... interested in using selection, evolution, and machine learning to solve difficult problems in chemistry...

...Aneesh's research interests include proteomics, machine learning, and visualization for big biology. GPS...collaborative database. Aneesh's research interests span machine learning, proteomics, and user interfaces for math...

...bacteria have poor non-homologous end joining machinery, so a CRISPR-induced double-stranded break (DSB...into the bacterial genome, and it carries CRISPR machinery targeting 1) the given resistance gene and 2) ...

...and the viral mRNAs are translated) by cellular machinery. NP encapsidates the negative sense, single-stranded.... These mRNAs are translated by cellular host machinery (as viral mRNAs would be in the course of viral...

...plasmids rely on their host cell's replication machinery in order to replicate—but not always to the same..., as they only require the host's replication machinery for elongation and termination. These types of...

... plasmids to utilize diverse host replication machinery. For instance, the ori typically contains iterons...However, if plasmids have their own replication machinery such as Rep or other initiator proteins, they ...

...these approaches, such as delivery of the editing machinery to the brain, minimizing off-target editing, and...https://doi.org/10.3389/fgene.2019.00625 McGraw CM, Samaco RC, Zoghbi HY (2011) Adult Neural Function Requires...

... consulting? Healthcare consultants advise pharmaceutical companies, biotech start-ups, health insurance...others go on to work with commercial teams at pharmaceutical companies, nonprofit or global health organizations...

...editing and longer genome search times. Using a machine learning approach, the lab proposed multiple sets...CRISPR-Cas9 PAM variants via scalable engineering and machine learning. Nature, 643(8071), 539–550. https://doi.org...

...generally considered first generation DNA sequencing machines (9). Today, similar technologies, sometimes referred...older technologies nanopore-based DNA sequencing machines are relatively small meaning that DNA sequencing...

...Submission to the British Journal of Pharmacology.” British Journal of Pharmacology, vol. 175, no. 3, Wiley, 19...

...building things, lots of math, and maybe heavy machinery. But not all engineering is at a large scale —...stability. Optimizing antibodies for better pharmacokinetics and reduced immunogenicity allows for more...

...involved in plasmid competition or can hijack machinery from other CRISPR systems to carry out various..., L., Kocalar, S., Oshiro, R., Makarova, K. S., Macrae, R. K., Koonin, E. V., & Zhang, F. (2023). Uncovering...

... produces modified dendritic cells (DCs) and macrophages (M1 and M2) that help create welcoming environments...over-express CD47 to escape recognition by circulating macrophages. Tumor cells also downregulate the expression...

...a technique that utilizes phage recombination machinery to promote homologous recombination of linear ...resistance E. coli carrying the phage recombineering machinery are first electroporated with pCas9. Then, pCRISPR...

...observations: Rapamycin is a membrane-permeable pharmacological agent that can rapidly induction heterodimerization...the Roth lab to be activated by otherwise pharmacologically inert drug-like small molecules, allowing ...

... industry, the bioethanol industry, and the pharmaceutical industry, depend on the yeast, Saccharomyces..., including fermented beer and wine, fuels, pharmaceutical ingredients, and recombinant proteins. In order...

...prime editing systems through manipulating MMR machinery. On the fifth day of CRISPR, Addgene gave to me...

...that will keep the lab running like a well-oiled machine. Lab tip #1: Glove trick Putting on lab gloves ...

...everything from Falcon tube trees to giant paper mache Krampus performing routine lab maintenance tasks...

...Gene Therapies 10:17-14:34 : Progress in Treating Macular Degeneration and Other Retinopathies 14:39-25:59...

...Investigator III at Novartis, a multinational pharmaceutical company based in Switzerland. After completing...

... University and his Master of Arts in Law and Diplomacy, with a focus on international technology management...

... Expression in Mammals Recombinase-based State Machines Enable Order-dependent Logic in vivo As always...

...Oxford University and then obtained a PhD in Pharmacology from the University of Cambridge before spending...

...from Addgene! References Kudo, T., Jeknić, S., Macklin, D.N., Akhter, S., Hughey, J.J., Regot, S., & Covert...