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Learn about evaluating DNA quality with Spectophotometry using a Nanodrop

July 1, 2025, 1:15 p.m.

Prime editing is a search-and-replace CRISPR editing method that offers versatility and precision in genome editing. We cover common prime editing tools.

Aug. 11, 2026, 1:15 p.m.

Curious about the history of C-myc, one of the most common antibody tags? Learn all about it here!

Jan. 19, 2023, 2:15 p.m.

Learn how you can use HDR and CRISPR to make a knock-in cell line for your research.

Dec. 22, 2022, 2:15 p.m.

We describe the different classes of optogenetic tools available and what levels of control they give you in your experimental setup.

June 27, 2023, 1:15 p.m.

An overview of cytosine and adenine base transition editors, which make precise changes in DNA bases without causing double-strand breaks.

Feb. 13, 2025, 2:15 p.m.

Learn what non-model organisms are, why scientists use them, and what they can teach us.

July 21, 2026, 1:15 p.m.

Learn about the advantages of using AAV as a delivery method for CRISPR screens.

Feb. 4, 2025, 2:15 p.m.

Learn about the best-in-class collection of AAV enhancers developed by the Allen Institute for Brain Science!

Sept. 9, 2025, 1:15 p.m.

X-CHIME, a series of CRISPR tools developed and deposited by Arlene Sharpe's lab, allows for germline knockouts in immune cells in mice.

Jan. 16, 2024, 6:13 p.m.

This post describes the development of sentinel plants, which change color to alert humans when they detect certain molecules in their environment.

March 3, 2026, 2:14 p.m.

Looking to use adenoviral vectors in your research? This post introduces you to the adenovius!

Oct. 3, 2023, 1:15 p.m.

Scientists at Beam Therapeutics have found a way to improve editing in primary human cells using evolved adenine base editors called ABE8.

May 7, 2020, 1:15 p.m.

Addgene's interviews Chris Voigt of MIT about the intersection of CRISPR and synthetic biology and his new work building circuits with CRISPRs.

April 22, 2015, 2:06 p.m.

Learn more about non-homologous end joining (NHEJ) and how it relates to genome engineering technologies such as CRISPR/Cas9.

April 16, 2015, 3:45 p.m.

CRISPR-Cas9 technology appears in numerous publications, including its use for genome editing in monkeys and x-ray crystallography of Cas9's 3-D shape.

March 11, 2014, 5:55 p.m.

Ready to produce rAAV in your own lab? This 101 post can help!

July 16, 2024, 1:15 p.m.

The tumor microenvironment is the cellular milieu that surrounds a tumor and contains immune cells, blood vessels, cells, and signaling molecules. What goes on in the cancer microenvironment affects and is affected and can either promote or repress tumor growth.

Jan. 31, 2019, 1:32 p.m.

Learn how AAVs can be used to trace neuronal connections.

Aug. 9, 2018, 1:04 p.m.

With the limitations of qRT-PCR based COVID-19 testing, scientists develop CRISPR-based diagnostic tools for COVID-19.

May 5, 2020, 1:15 p.m.