Deaminet 2026: Breakthroughs in Base Editing, Deaminase Biology, and Therapeutic Translation
Type
Blog Post
Published
March 10, 2026, 1:14 p.m.
... comprehensive off-target assessments, and IND-enabling studies.
PERT: A disease-agnostic prime editing...convert an endogenous tRNA into a suppressor tRNA, enabling readthrough of nonsense mutations without lifelong...barrier for pan-mutation editing strategies by enabling large sequence integration without triggering ... and is currently in Phase 1b/2a trials, with published clinical data showing durable production of functional...tumors to immune-responsive ones and potentially enabling new immunotherapy combinations.
Taken together... an important reminder that the same chemistry enabling precise genome editing can profoundly reshape ...presented at Deaminet 2026 are advancing through IND-enabling studies using editing tools developed only a few...