We narrowed to 227 results for: mel
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TypeBlog PostPublishedJune 27, 2018, 1:16 p.m....regard and is even able to reverse transcribe the extremely long, highly structured HCV genome (~9.6 kb of...engineered from heavy-chain only antibodies found in camelids. They possess many advantages over conventional...
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Safe Port in a Storm...How Addgene is Weathering the Pandemic
TypeBlog PostPublishedSept. 17, 2020, 1:15 p.m.... with 80% of the team working remotely. We’re extremely proud of the work we’ve done to support COVID-...the spring and early summer months. We are also extremely grateful to the grant officers at Fast Grants.... -
Creating accessible biology activities in schools with BioBits
TypeBlog PostPublishedAug. 2, 2018, 12:56 p.m....certain chemicals into fragrances that they can smell, or enzymes that can create hydrogels that they ...textbooks with real world results that they can see, smell, and touch. Along the way, we hope they’ll also ... -
Learning Technical Skills at a Lab Central Workshop
TypeBlog PostPublishedFeb. 20, 2018, 2:30 p.m....who was working with cell culture and who was extremely helpful since she was familiar with library generation...resource for the research community, so it is extremely important for us as a company to constantly update... -
Improving Transduction Efficiency with Exosome AAVs
TypeBlog PostPublishedMarch 14, 2019, 1:54 p.m....IX in liver in a mouse model of Haemophilia B (Meliani et al., 2017). Exo-AAV9 was successfully shown ...PMID: 22314290. PubMed Central PMCID: PMC3345986. Meliani, Amine, et al. "Enhanced liver gene transfer and... -
Addgene-Seeding Labs plasmid grant round 3: microbial drug resistance and biofilms, antidiabetic plant components, visualizing brain injury - and a glowing robot fish
TypeBlog PostPublishedNov. 27, 2018, 2 p.m....compounds with antidiabetic properties that can ameliorate diabetics nephropathy, one of the major pathophysiological...pathophysiological complications of diabetes mellitus. Recombinant human proteins that play a role in insulin... -
Predicting Adverse Reactions to Monoclonal Antibody Drugs
TypeBlog PostPublishedFeb. 13, 2024, 2:15 p.m....From Manufacturing to Preclinical Studies. In J. Bluemel, S. Korte, E. Schenck, & G. F. Weinbauer (Eds.)...doi.org/10.1016/B978-0-12-417144-2.00027-5van Brummelen, E. M., Ros, W., Wolbink, G., Beijnen, J. H., ... -
R Bodies: Membrane-Rupturing Microscopic Tools
TypeBlog PostPublishedApril 14, 2016, 2:30 p.m....Jessica Polka, a Postdoctoral Research Fellow with Pamela Silver. Most types of biological motion (whether...Jessica Polka is a Postdoctoral Research Fellow with Pamela Silver in the department of Systems Biology at ... -
Viral Vectors 101: Viral Applications
TypeBlog PostPublishedApril 13, 2023, 1:15 p.m....in the limelight. The FDA approved the first oncolytic viral therapy in 2015 to treat melanoma, and many... -
Developing a cold tolerant E. coli using specialized chaperones
TypeBlog PostPublishedJan. 28, 2020, 2:35 p.m.... corrosive pH ranges, crushing pressures, near-melting temperatures, tons of radiation, or freezing cold...operational time for a given process. These are extremely useful benefits for any food processing industry... -
Addgene: The First Twenty Years
TypeBlog PostPublishedDec. 19, 2024, 2:15 p.m....websites, Facebook and Gmail, were launched. And Melina Fan, a cell biology graduate student, was frustrated... A blast from the past: Cofounder and CSO Melina Fan setting up Addgene's very first in-house NGS... -
Working with Nuclear Receptors
TypeBlog PostPublishedJuly 15, 2014, 4:03 p.m....be required by one or more NRs for efficient and timely activation or repression of gene expression (see...the research literature and acquiring them in a timely manner. Addgene represents an excellent solution... -
Viral Vectors 101: Calcium Sensors
TypeBlog PostPublishedAug. 10, 2023, 1 p.m....mitochondria), the Cameleon-based FRET sensor D1ER, and GCaMPER. Bonus: There are also Cameleon-based FRET sensors... -
Adapting Toehold Switches to Detect Zika Virus
TypeBlog PostPublishedAug. 30, 2016, 2:30 p.m....publication timeline I think we can speak for all the authors on the paper when we say the timeline to develop... -
Reaching out to China: Canton Nucleic Acids Forum (CNAF) 2015
TypeBlog PostPublishedDec. 1, 2015, 3:30 p.m....by Nobel Laureate (and Addgene depositor) Craig Mello. Taking his groundbreaking work in RNAi one step...involved in preventing silencing of self-genes. Dr. Mello presented a hypothesis that these pathways are involved... -
Polymerase Chain Reaction Overview and Applications
TypeBlog PostPublishedAug. 10, 2021, 1:15 p.m....molecular cloning, sequencing, and genotyping. It’s extremely useful but is not as quantitative as other methods...multiple primers all in one PCR reaction. This is an extremely useful PCR method that can help save time and ... -
Mobile-CRISPRi: Bringing CRISPRi to Diverse Bacteria
TypeBlog PostPublishedApril 4, 2019, 12:53 p.m....plasmids, and lack the ability to synthesize diaminopimelic acid (DAP), a component of the cell wall. Once...Central PMCID: PMC5180612. Libby, Elizabeth A., and Pamela A. Silver. "Harnessing undomesticated life." Nature... -
Experimenting with New Careers while in Grad School
TypeBlog PostPublishedFeb. 25, 2016, 3:30 p.m....This post was contributed by guest blogger Melanie Fox, founder and executive director of Central Indiana...fully take advantage of my graduate experience. Melanie Fox is currently the founder and executive director... -
Plasmids 101: Secondary Nanobody Toolbox
TypeBlog PostPublishedFeb. 27, 2018, 2:04 p.m....antibody (HCab), which are unique to camels, llamas, alpacas and other camelids. In terms of structure, HCabs... -
SciComm: Taking Science to Elementary and Middle Schools
TypeBlog PostPublishedJuly 9, 2019, 12:52 p.m....does, and how one becomes a scientist. I gave a timeline of my science life, starting back to Mr. Kelley...engaging examples of how understanding genetics is so timely.” Genome engineering, and many other technologies...