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We narrowed to 816 results for: ache

Showing: 601 - 620 of 816 results

  2. Deciphering the Mysteries of Behavior with Viral Vectors

    Type
    Blog Post
    Published
    Sept. 17, 2019, 12:40 p.m.
    ...and might open new ways for a novel therapeutic approach against drug addiction. Anxiety tests Rodents...found that downregulating expression of miR124a achieved a similar improvement in the forced swim test....

  4. Lab to Office Culture Shock

    Type
    Blog Post
    Published
    Feb. 5, 2019, 1:04 p.m.
    ...to office will likely happen eventually. If you approach that transition dreading the change, the adjustment...adjustment period will be that much longer. If you approach the transition embracing the opportunity for growth...

  5. CRISPR-mediated Plant Base Editors

    Type
    Blog Post
    Published
    Jan. 3, 2019, 1:35 p.m.
    ...efficient base rewriting in the genome became achievable in 2016 when two independent groups (Komor et...is either repaired by cellular mismatch repair machinery making an original C-G pair converted to T-A or...

  6. To Codon Optimize or Not: That is the Question

    Type
    Blog Post
    Published
    Nov. 12, 2020, 2:15 p.m.
    ...is codon optimization? Codon optimization is an approach in gene engineering to improve gene expression... several codons that encode the same amino acid. Each organism, however, may preferentially use one codon...

  7. Hot Plasmids - August 2020

    Type
    Blog Post
    Published
    Aug. 18, 2020, 1:15 p.m.
    ... have created a yeast-based directed evolution approach with some notable improvements. Directed evolution...specific guide RNA (gRNA) sequences. But these approaches rely on continual expression of both dCas9 and...

  8. Finding nucleic acids with SHERLOCK and DETECTR

    Type
    Blog Post
    Published
    April 16, 2020, 1 p.m.
    ...combined with different fluorescent reporters for each enzyme. In addition, Csm6, a CRISPR type-III effector...Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya RP, Livny J, Regev A, Koonin EV, Hung DT, Sabeti...

  9. Antibodies 101: Immunoprecipitation

    Type
    Blog Post
    Published
    Dec. 7, 2021, 2:15 p.m.
    ...measure the target. However, the two different approaches allow for optimized strategies for differing ...specificity of anti-epitope antibodies make this approach appealing, but the disadvantages must be carefully...

  10. Viral Vectors 101: Pseudotyping

    Type
    Blog Post
    Published
    April 20, 2021, 2:30 p.m.
    ...withstand ultracentrifugation which helps scientists achieve a high titer (reviewed in Joglekar and Sandoval... can bind and transduce many cell types before reaching the target cells. VSV-G is also toxic at high ...

  11. Transferable Skills Guide: Career Planning Resources

    Type
    Blog Post
    Published
    Nov. 14, 2017, 2 p.m.
    ...re likely to find current job openings. A good approach is to do this first for companies at which you...originally called about, you can keep in touch and reach back out when you are looking to change positions...

  12. 5 Reasons to Use Reddit for Science Communication

    Type
    Blog Post
    Published
    Oct. 20, 2016, 2:30 p.m.
    ... filtered out inflammatory questions, and even coached us on how to write our AMA submission to avoid ...etc. database. Still have questions? I am easy to reach and happy to help. Additional Resources on the ...

  13. Tips for CRISPR Gene Editing in Mice

    Type
    Blog Post
    Published
    June 28, 2016, 10:59 a.m.
    ...cells was being explored and it allowed control over each individual component of the system. However, it ...details on what exactly has been inserted or deleted. Each lab will use a slightly different method to genotype...

  14. Plasmids 101: Control Plasmids

    Type
    Blog Post
    Published
    April 9, 2015, 3:29 p.m.
    ...because the purified plasmid, cells, and media used in each of the wells are not independent: they were derived...consuming and ultimately more important. Ideally, each biological replicate should use fresh media, test...

  15. Data Freedom: The Expansion of Data Sharing in Research Publications

    Type
    Blog Post
    Published
    Aug. 5, 2014, 6:51 p.m.
    ...interpretation of the experiment would require access to each individual video. To PLOS’s credit, the organization...three-fold. Firstly, we rely on many other labs to teach us how to do experiments and understand their data...

  16. Plasmids 101: The Promoter Region – Let's Go!

    Type
    Blog Post
    Published
    April 3, 2014, 8:05 p.m.
    ...however, eukaryotes have muliple polymerases which are each responsible for a specific subset of RNAs. To gain... in your host organism. Because transcription machinery differs between cell types or organisms, promoters...

  17. Harnessing Bacterial Toxins for Allelic Exchange

    Type
    Blog Post
    Published
    Aug. 15, 2019, 12:30 p.m.
    ...recombination events, but because these events are rare, each requires selection. These two steps are (Figure...medicine and clinical infectious diseases at the Massachusetts General Hospital where he is now an attending...

  18. Five Popular Model Organisms, Part 2

    Type
    Blog Post
    Published
    Sept. 29, 2020, 1:15 p.m.
    ... makes it a perfect candidate for introductory teaching and research environments (Idalia & Bernardo, ...scientists around the world worked to characterize each gene’s function. Some key genetics research with...

  19. Hot Biosensors 2022: Year-End Roundup

    Type
    Blog Post
    Published
    Dec. 6, 2022, 2:15 p.m.
    ...getting dark and wintry with the end of year approaching. We’re always looking for something to brighten...screening platform developed here is also a promising approach for developing sensors for other targets. Figure...
Showing: 601 - 620 of 816 results