We narrowed to 904 results for: CAN

...alter the type of nucleic acid sequences that Cas9 can target." As further proof of just how big and mainstream...there's a pretty good reason for that. Lately, significant advances in the understanding and application...microbiome alone. (Seriously, is there anything CRISPRs can't do?) Structural details All this, and scientists...

...sequences, for instance, the enzymes are activated and can cleave fluorescent probes of dsDNA and RNA in trans...cutting ssDNA but not dsDNA Cas14 is not a good candidate for a new genome-editing tool but it could be ...the quick and efficient diagnoses of infections, cancer, and other diseases. References 1. Harrington,...

...similar events show how meaningful science outreach can be, both for scientists and the public. For students...three broad concepts: the genetic basis of disease, cancer, and viral infections. An interactive lunch with...

...It’s well known that exercise can help fight stress and depression, and now researchers have reported... key because, unlike kynurenine, kynurenic acid can’t cross the blood-brain barrier. By lowering circulating...

...Luminescent molecules are very useful tools because we can easily detect and measure the light they emit. Proteins...

... differentiating surfactant producing cells that can be used to better understand the biology of certain...

...DNA to you, we'd save you days of time so that you can begin your cloning experiment right away. And without...multiple plasmids in one cell, it might be that you can't stably maintain them in the cell. This blog post...

...toolkit for Burkholderia, a genus of bacteria that can cause disease in humans. Expression of this system...

...Tracer Library Has Been Used in Cancer Lineage Tracing Read How CRISPR Can Be Used in Genome-Wide Screening...When cancers are treated with drugs designed to hit them right where it hurts, the effects are often ...is that, in a relatively short amount of time, cancers become resistant to drugs, particularly targeted... yet have a comprehensive understanding of how cancers become resistant, an emerging theme is that they...differentiation.” https://www.addgene.org/kits/sabatini-wood-cancer-pathway-orfs/ Finding signaling pathways involved...signaling pathways that are frequently implicated in cancer cell proliferation, survival, differentiation, ... usable for pooled screens. Applications of the cancer pathways ORFs kit Wood and his colleagues developed...

... the Scale: NSF's Career Life-Balance Initiative Can Scientists Maintain a Good Work-Life Balance? Read...

...working at Addgene. We’re a small non-profit, so we can only provide free food on special occasions. However...

...space in the viral genome so that a gene of interest can be packaged into the virus instead.  Next let’s take...

...vector containing a gRNA. These transduced stem cells can be implanted in irradiated recipients to create mice...phosphatases, PTPN1 and PTPN2, which are of interest as cancer immunotherapy targets but are embryonic lethal,...interested in improving CD8+ T cell responses to cancer.     References and resources References LaFleur...

...fold higher expression levels compared to AAV9. You can now target these cells with AAV-CAG-GFP packaged ...

...run or risk minor electrocution.  These days you can buy small gel boxes, but none as small as the baby...to throw out chipped or imperfect equipment.  We can’t safely recycle these materials either.  Test tubes...

...questions.   Advice for success in academia How can we shape our time in academia to maximize productivity...

...possible with conventional FPs. In addition, PA FPs can improve the achievable signal-to-background ratio...resolution images in vivo. “One of the reasons we can’t localize one cell at a depth of one centimeter with...

...products is desired, as multiple selection markers can ensure that all desired tags have been integrated...

...project the expression of isolated bacterial proteins can be achieved using a bacterial expression system such...expression of nutritionally and therapeutically significant proteins. In this project she aims to create ...essential, which means that the body requires them but cannot produce them. By using yeast integration vectors...

...term "nonprofit" is a bit misleading. Nonprofits can generate revenue (as Addgene does through materials...service organization like the Red Cross or the American Cancer Society, or maybe you think about a local food...do with their revenue. A nonprofit organization cannot distribute profits to private individuals through...