We narrowed to 899 results for: CAN
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TypeBlog PostPublishedJuly 7, 2017, 1:32 p.m.... differentiating surfactant producing cells that can be used to better understand the biology of certain...
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Fluorescent Proteins 101: History of Fluorescent Proteins
TypeBlog PostPublishedAug. 7, 2017, 1:58 p.m....Luminescent molecules are very useful tools because we can easily detect and measure the light they emit. Proteins... -
What's New in CRISPR - December 2019
TypeBlog PostPublishedDec. 17, 2019, 2:37 p.m....toolkit for Burkholderia, a genus of bacteria that can cause disease in humans. Expression of this system... -
Modulate the Activity of 17 Signaling Pathways with One Kit!
TypeBlog PostPublishedMarch 22, 2016, 2:30 p.m....Tracer Library Has Been Used in Cancer Lineage Tracing Read How CRISPR Can Be Used in Genome-Wide Screening...When cancers are treated with drugs designed to hit them right where it hurts, the effects are often ...is that, in a relatively short amount of time, cancers become resistant to drugs, particularly targeted... yet have a comprehensive understanding of how cancers become resistant, an emerging theme is that they...differentiation.” https://www.addgene.org/kits/sabatini-wood-cancer-pathway-orfs/ Finding signaling pathways involved...signaling pathways that are frequently implicated in cancer cell proliferation, survival, differentiation, ... usable for pooled screens. Applications of the cancer pathways ORFs kit Wood and his colleagues developed... -
Celebrating Accomplishments in the Lab
TypeBlog PostPublishedMay 8, 2014, 3:07 p.m.... the Scale: NSF's Career Life-Balance Initiative Can Scientists Maintain a Good Work-Life Balance? Read... -
From our Table to Yours: An Inside Look at Lunch at Addgene
TypeBlog PostPublishedNov. 27, 2013, 2:54 p.m....working at Addgene. We’re a small non-profit, so we can only provide free food on special occasions. However... -
Viral Vectors 101: Parts of the AAV Packaging Plasmid
TypeBlog PostPublishedDec. 3, 2020, 2:15 p.m....space in the viral genome so that a gene of interest can be packaged into the virus instead. Next let’s take... -
X-CHIME: Context Dependent Germline Knockout in Immune Cells
TypeBlog PostPublishedJan. 16, 2024, 6:13 p.m....vector containing a gRNA. These transduced stem cells can be implanted in irradiated recipients to create mice...phosphatases, PTPN1 and PTPN2, which are of interest as cancer immunotherapy targets but are embryonic lethal,...interested in improving CD8+ T cell responses to cancer. References and resources References LaFleur... -
New Viral Vectors - Fall 2024
TypeBlog PostPublishedOct. 3, 2024, 1:15 p.m....fold higher expression levels compared to AAV9. You can now target these cells with AAV-CAG-GFP packaged ... -
The Stingy Scientist: How the Baby Gel Box Was Born
TypeBlog PostPublishedApril 15, 2014, 3:11 p.m....run or risk minor electrocution. These days you can buy small gel boxes, but none as small as the baby...to throw out chipped or imperfect equipment. We can’t safely recycle these materials either. Test tubes... -
9 Tips to Achieve Success in Academia
TypeBlog PostPublishedApril 1, 2014, 5:33 p.m....questions. Advice for success in academia How can we shape our time in academia to maximize productivity... -
In Living Color: The Skinny on In Vivo Imaging Tools
TypeBlog PostPublishedMarch 27, 2014, 5:14 p.m....possible with conventional FPs. In addition, PA FPs can improve the achievable signal-to-background ratio...resolution images in vivo. “One of the reasons we can’t localize one cell at a depth of one centimeter with... -
Tag Your Favorite Yeast Genes with Ease
TypeBlog PostPublishedNov. 19, 2013, 2:37 p.m....products is desired, as multiple selection markers can ensure that all desired tags have been integrated... -
CRISPR Challenges: Standardization and Homology Directed Repair
TypeBlog PostPublishedFeb. 14, 2018, 2:36 p.m....describe how a better understanding of Cas9 biophysics can help enhance HDR. CRISPR 101: Ribonucleoprotein (... -
Addgene's a Nonprofit? Nonprofit Awareness Day 2017
TypeBlog PostPublishedJune 5, 2017, 3:19 p.m....term "nonprofit" is a bit misleading. Nonprofits can generate revenue (as Addgene does through materials...service organization like the Red Cross or the American Cancer Society, or maybe you think about a local food...do with their revenue. A nonprofit organization cannot distribute profits to private individuals through... -
New Viral Vectors - Winter 2025
TypeBlog PostPublishedJan. 28, 2025, noon...serotypes. Not sure what to request? Addgene's Data Hub can help, with over 100 user-submitted viral vector reports...pAAV-EF1α-F-FLEX-mNaChBac-T2A-tdTomato AAV8 Molecular tool Massimo Scanziani New viral prep pAAV_hSyn1-SIO-stGtACR2-FusionRed... -
Running for Rare Disease, Running for FOP, Running for AJ
TypeBlog PostPublishedSept. 15, 2016, 2:30 p.m....Running4Rare are paired with patient partners so that they can help tell their stories. I was paired with a six-...named AJ Gonzales who suffers from Fibrodysplasia ossificans progressiva (AKA FOP). This terrible disease ...always work as efficiently in humans. This is why we cannot stop searching for novel solutions to treat rare... -
Addgene-Seeding Labs Plasmid Grant: Accelerating Science Globally - 5 Scientists, 4 Countries & 3 Continents!
TypeBlog PostPublishedJuly 18, 2017, 12:41 p.m....project the expression of isolated bacterial proteins can be achieved using a bacterial expression system such...expression of nutritionally and therapeutically significant proteins. In this project she aims to create ...essential, which means that the body requires them but cannot produce them. By using yeast integration vectors... -
Addgene @ Keystone: Thoughts on Precision Genome Engineering and Synbio
TypeBlog PostPublishedJan. 15, 2015, 1:50 p.m....challenges of creating biological circuits, and I can only say this science is really, really hard. That... -
Science Careers: Unruly Interests Feed Many Paths
TypeBlog PostPublishedSept. 26, 2017, 12:12 p.m....New Yorker’s “Comma Queen” shows how punctuation can be wildly funny as well as financially critical. ...and jobs. At Science, which is published by the American Association for the Advancement of Science (AAAS...Senior Editor at Science magazine, published by the American Association for the Advancement of Science. She...