We narrowed to 911 results for: CAN

...reflecting on a question of impact that only you can answer: How would you like to measure yours? More...

...recently that desired genome-editing events by HDR can be generated more efficiently by (1) improving editing...template containing blocking and intended mutations can be equally mixed with another ssODN template that...

... amino acids, can also be packaged into AAV. NmeCas9 has the added advantage that it can be turned off...

...synthetic biology techniques in biology research as can already be seen with things like DNA synthesis, Golden...

... sure scientists all over the world know that we can help with plasmid sharing! Judging by how many prizes...

...they need for their research, show labs how they can benefit from depositing their constructs to the repository...

...alter the type of nucleic acid sequences that Cas9 can target." As further proof of just how big and mainstream...there's a pretty good reason for that. Lately, significant advances in the understanding and application...microbiome alone. (Seriously, is there anything CRISPRs can't do?) Structural details All this, and scientists...

...sequences, for instance, the enzymes are activated and can cleave fluorescent probes of dsDNA and RNA in trans...cutting ssDNA but not dsDNA Cas14 is not a good candidate for a new genome-editing tool but it could be ...the quick and efficient diagnoses of infections, cancer, and other diseases. References 1. Harrington,...

...similar events show how meaningful science outreach can be, both for scientists and the public. For students...three broad concepts: the genetic basis of disease, cancer, and viral infections. An interactive lunch with...

...It’s well known that exercise can help fight stress and depression, and now researchers have reported... key because, unlike kynurenine, kynurenic acid can’t cross the blood-brain barrier. By lowering circulating...

...Luminescent molecules are very useful tools because we can easily detect and measure the light they emit. Proteins...

... differentiating surfactant producing cells that can be used to better understand the biology of certain...

...toolkit for Burkholderia, a genus of bacteria that can cause disease in humans. Expression of this system...

...DNA to you, we'd save you days of time so that you can begin your cloning experiment right away. And without...multiple plasmids in one cell, it might be that you can't stably maintain them in the cell. This blog post...

...Tracer Library Has Been Used in Cancer Lineage Tracing Read How CRISPR Can Be Used in Genome-Wide Screening...When cancers are treated with drugs designed to hit them right where it hurts, the effects are often ...is that, in a relatively short amount of time, cancers become resistant to drugs, particularly targeted... yet have a comprehensive understanding of how cancers become resistant, an emerging theme is that they...differentiation.” https://www.addgene.org/kits/sabatini-wood-cancer-pathway-orfs/ Finding signaling pathways involved...signaling pathways that are frequently implicated in cancer cell proliferation, survival, differentiation, ... usable for pooled screens. Applications of the cancer pathways ORFs kit Wood and his colleagues developed...

... the Scale: NSF's Career Life-Balance Initiative Can Scientists Maintain a Good Work-Life Balance? Read...

...working at Addgene. We’re a small non-profit, so we can only provide free food on special occasions. However...

...fold higher expression levels compared to AAV9. You can now target these cells with AAV-CAG-GFP packaged ...

...space in the viral genome so that a gene of interest can be packaged into the virus instead.  Next let’s take...

...vector containing a gRNA. These transduced stem cells can be implanted in irradiated recipients to create mice...phosphatases, PTPN1 and PTPN2, which are of interest as cancer immunotherapy targets but are embryonic lethal,...interested in improving CD8+ T cell responses to cancer.     References and resources References LaFleur...