...Neurodegeneration Research Collection. This page is regularly updated with useful materials for research into Alzheimer...editor PE7 Antibodies to facilitate SARS-CoV-2 research New viral vector preps of Voltron2 voltage sensors...motif to stabilize the 3’ end of the pegRNA. As research has just begun with PE7, it will be exciting to...38570691. Antibodies to facilitate SARS-CoV-2 research   By Ashley Waldron Ready-to-use recombinant antibodies... the Addgene repository of tools for SAR-CoV-2 research. Two new antibodies, Anti-SARS-CoV-2 Nucleocapsid...immune cells is critical for central nervous system research; however, microglia are notoriously resistant ...provides a simple yet valuable tool for microglia research and broader therapeutic applications.  Find microglia-targeting...

...ensuring that our services help accelerate your research. We know you don’t have time to be waiting on ...dedicated support team that can help you through any search, ordering, technical, or quality control issues...can browse through our various FAQ categories or search through the entire FAQ collection. You’ll find ... you are on our site. Simply click on the icon, search for answers, and choose a result. By clicking on...feedback. This is Addgene after all, and making your research easier always comes first. Resources on the Addgene... Visit the Help Center Find Plasmids for Your Research Become a Member of the Addgene Community  ... Bryan Archambault...

... for their function. With the right research reagents, researchers can measure this conformational change...Innovation (IPI), a Boston-based, nonprofit protein research institute, partnered with Addgene to make our ...therefore interrupt integrin function — providing researchers new tools to identify integrin presence, study...ligand-binding functions, all key to basic biomedical research and drug development. Integrin structure and conformational...elucidating the role of tension, however, the researchers realized they needed specific tools to interpret... working with Addgene to accelerate biomedical research by distributing antibodies developed by IPI. Our...process behind the scenes to the new antibodies and research coming out of the lab.  References and resources...

...called “Teaching Your Research.” This course has participants take their research from the bench to the... level course based on their research interests. “So for me, I researched G-proteins at the time. This...program takes what you know about it [your area of research], and teaches you how to design a course, how ...off: “I spent about 6 months just editing and searching for a job and I stumbled upon eScience by luck...happenstance. It was on Indeed or one of the job search sites. It's  a rare trek these days to go in cold...

...including Addgene, positively affect scientific research. As Maria Castro of University of Michigan says... as the technology disseminates throughout the research community. These popular plasmids are categorized...distributed this year, serves to congratulate researchers who have at least one plasmid deposited at Addgene...generously shared their reagents freely with the research community. Sharing is caring We’re thrilled that...time for our depositors to continue conducting research. Said Blue Flame awardee Sophien Kamoun of the... we’re also proud to help connect scientific researchers from far corners of the world. “It’s easy to ...eliminate geographical restrictions in life science research." Claim Your Award If you have one or more blue...

... this position because I want to help make the research enterprise work better and because I really like...back on. While doing and presenting undergraduate research at BU, I realized that I’m energized by talking...difficulties behind great discoveries by tackling a research project and getting a PhD myself. To continue ...graduate student group, Science in the News. While research experience is key to my current position, I think...Kentucky where I spent a couple of days talking to researchers about their work, picking up plasmid deposits...ways Addgene can improve in its mission to make research easier. I’m hoping my story demonstrates that ...mine, that help support academia but the skills researchers gain doing PhDs (i.e. technical writing, teaching...

...fans of all forms of research sharing and with Open Data Day 2020 coming up on March 7th, what better way...resource. Instead of painstakingly searching for experimental details in research articles, scientists can use...experiments using a specific AAV tool. They can search the database by certain features like serotype,...the dedicated community of data-contributing researchers who use AAV tools. This word cloud (using...open data resource and accelerating reproducible research. Share your data on AAV data hub! Related resources...

...scientists have been coming to the Addgene website in search of plasmids. Now, scientists are beginning to see...classification This inquiry started when Neil Thompson, a research scientist at MIT’s Computer Science and Artificial... MIT labs in the Synthetic Biology Engineering Research Consortium. That is how Aditya Kunjapur, a MIT... gene sequences as natural or synthetic, the researchers looked at intrinsic properties (GC content or...85% correlates with synthetic sequences. The researchers then used their classifier to identify synthetic...lab-of-origin of engineered DNA This isn’t the only time researchers have used Addgene as a large data set. Alec A...Addgene.org Check out Addgene's synthetic biology page Search for a plasmid Find Addgene's most popular plasmids...

...promote reproducibility, Addgene will have unique Research Resource Identifiers (RRIDs) for each antibody...connects colleagues and is invested in improving research infrastructure, from our educational materials...funded by a generous grant from the NIH’s Brain Research Through Advancing Innovative Neurotechnologies...continue to add more antibodies, for neuroscience research and other disciplines, over time. The resource...Resources As part of our commitment to supporting your research, Addgene is creating an array of educational materials... that you will find useful antibodies for your research. Please consider sharing your experiences with...Reproducibility: Standardize antibodies used in research. Nature 518:27–29. https://doi.org/10.1038/518027a...

...year. While we love academic research, we hope we can help all researchers achieve happiness in their careers... on a diverse array of topics pertinent to the research community, two eBooks (Management for Scientists... science and the plasmids, technologies, and researchers behind them. As part of our thanks to you for...and CRISPR 101 series. These posts aim to give researchers the background they need to get started using... bring about the next revolution in biological research. We’re incredibly happy to see that one of our...deletions, and translocations. It also provides researchers with many different ways to control gene expression...

...represent different research areas, target readers, methodologies, or qualities of research our adjustment ...influence the direction of scientific research. View her research on her SSRN Author page: https://ssrn.com... Management. His research focuses on a range of topics including biotech and research tools, computing...Biochemistry & Molecular Biology, and Biochemical Research Methods. We also pulled the big interdisciplinary...

...agreement that states the terms of use for a tangible research material that is shared between two parties. There... for organizations to make policy decisions on research use agreements. The UBMTA, which is the MTA most...well-understood and accepted by the majority of research institutes.  Pro tip! In most academic and nonprofit...Transfer department is responsible for managing research use agreements like MTAs.  Addgene does a lot ...plasmids at Addgene are shared under the UBMTA, researchers additionally have the option of distributing ...which allows the plasmids to be distributed for research use only to industry-based scientists. Some organizations...OpenMTA, which allows plasmids to be used for both research and commercial purposes. It’s important to note...

...he helps researchers in a variety of fields develop RNAi screens to answer their own research questions...guide and promote Addgene in its mission to make research easier. Addgene is excited to announce that we...ended... it was actually something bordering on research, rather than 'here’s the protocol, get a result...later realizing that he wanted to continue doing research, Doench went on to apply to graduate school at...incredible place.” Doench has spent most of his research career working on miRNAs and RNAi. He first heard...specificity in the miRNA regulatory process. This early research is still relevant to his work at the Broad Institute...

...wondering “What is this PI looking for in a new researcher?,” “How do I convince the PI to choose me?” We...about awesome science. Important factors in the search for a lab Studies show that job satisfaction (especially...graduate student or postdoc. Although the chosen research field is important, the end goal during this time...tasks like a scientist. Of course, the specific research field should be interesting; however, this should...biotech, this is one case where the topic of your research can make your transition easier – choose a lab...Posts in this Blog Series: Advice for Choosing a Research Project 9 Tips to Achieve Success in Academia... search for a lab...

...mission is to Accelerate research and discovery by improving access to useful research materials and information...Can Use the Viral Service in Your Research Using Virus in Your Research - A Primer for Beginners Resources...lab from MIT and Alla Karpova’s lab from Janelia Research Campus have provided valuable insight into AAV...focus on assisting scientists and accelerating research and discovery, while also pushing us to challenge...Visit Our Viral Vector Pages Find Virus for Your Research ...

...selecting which particular AAVs to use for your research. Below I’ll provide some tips that will help you...think about how to get started with AAVs. Since my research is rooted in the CNS, my focus will be mostly ...tolerated, then axonal transport is fine and a researcher should aim to inject a larger amount of vector...kB [9]).     4. The Future What new types of research may be enabled by the use of AAVs? 1) Combined...potential problem in many experiments, a group of researchers has identified this feature of AAVs as a new ... to study neural control. Surprisingly, little research has compared and contrasted optogenetic and chemogenetic... the most appropriate vehicle for this type of research, as they are safe to use in vivo. 3) The use ...

...Gary McDowell, executive director of Future of Research. On December 1st 2016, many postdocs working more...reversing these decisions entirely. At Future of Research, we had been collecting data and documenting the...blogpost and more recently in a paper published in F1000Research on November 2016. Due to the nature of the postdoc...was granted nationwide. Again, we at Future of Research believe that, while the mandate has been removed...what their institution is doing from Future of Research over social media, not from their institution)... currently the Executive Director of Future of Research. He is interested in advocating for and with junior... him on Twitter @BiophysicalFrog and Future of Research @FORsymp.   Additional Resources on the Addgene...

...materials, Sonali Roy, a postdoctoral researcher at the Noble Research Institute, co-instructed the ASPB ...organized a panel to discuss reproducibility issues in research. But he realized that it wasn’t enough to discuss... that running interactive workshops to train researchers on tools and best practices could be an actionable... practices being adopted by a wider group of researchers. Generating material to empower others to practice... the materials in one place and better serve researchers at all levels of the scientific community. Lessons...interactive workshops that train and provide researchers with tools and best practices could be an actionable...

...by guest blogger Fredrik Wermeling, leader of a research group at the Centrum for Molecular Medicine (CMM... different gRNAs. It has been suggested that researchers should use ~400X more cells than gRNAs in a screen...are addressing a well-defined, hypothesis driven research question. Examples of custom CRISPR screens Differentially...analyses like RNAseq are getting lower and lower, the research community is generating a massive amount of descriptive...such data. These targeted screens can allow a researcher to test which of the differentially expressed...embedded. These were kindly donated by six different research constellations: Doench/Root (2), Zhang (3), Wu...screen! Final note I am very grateful to the researchers letting us use their reference libraries thereby...

...longer than we’ve been studying it and, now, researchers are exploring ways to bolster and modulate our...protein blocking. Other molecular targets under research include TIM-3, LAG-3, STAT-3, EGFR, CD20 and CD73...to activate them are a few methodologies being researched. Apoptotic and necroptotic tumor cells have also...engineering have played a huge role. For instance, researchers are genetically altering tumor cells and immune... treatments enter the clinic, physicians and researchers are learning much about how treatment regimens... made more effective. Some important factors researchers are beginning to focus on include: Cell heterogeneity... important questions in this exciting field of research. One of the most important: How will cancers evolve...