We narrowed to 215 results for: Mac
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TypeBlog PostPublishedMarch 24, 2020, 1:15 p.m....0005-2744(74)90240-x Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ (1979) Isolation of biologically...
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Human Germline Editing Using CRISPR
TypeBlog PostPublishedAug. 10, 2017, 2:19 p.m....circumvent this problem, they co-injected CRISPR machinery with sperm into M phase oocytes, thus allowing... -
Lighting Up Cell Signaling with Photoswitchable Kinases
TypeBlog PostPublishedJuly 25, 2017, 1:20 p.m....provide greater spatiotemporal resolution than pharmacological or genetic approaches, but only a few such ... -
Giving gRNAs a Facelift - Synthetic and Beyond
TypeBlog PostPublishedOct. 20, 2022, 1:15 p.m....samples. RNA is inherently less stable than most macromolecules used in scientific research such as DNA or ... -
Viral Vectors 101: An Introduction to AAV
TypeBlog PostPublishedMay 30, 2023, 1:15 p.m....expression AAVs have to infect cells, hijack host cell machinery, and synthesize a second strand of DNA before ... -
All in a Twist: dsRNA
TypeBlog PostPublishedFeb. 2, 2023, 2:15 p.m....foreign dsRNA activates the innate immune response machinery of the host. This pathway has been clinically... -
Tagging Optogenetics and Chemogenetics Receptors: Fluorescent Proteins and Other Options
TypeBlog PostPublishedMay 11, 2021, 1:15 p.m....10.1073/pnas.0700293104 Field J, Nikawa J, Broek D, MacDonald B, Rodgers L, Wilson IA, Lerner RA, Wigler M (... -
Working with Nuclear Receptors
TypeBlog PostPublishedJuly 15, 2014, 4:03 p.m....physiological states such as adipogenesis and macrophage activation. Our mass spectrometry-affinity purification... -
CRISPR 101: Targeting Non-Coding RNAs with CRISPR/Cas9
TypeBlog PostPublishedNov. 14, 2024, 2:15 p.m.... sgRNA to temporarily block the transcription machinery of a target gene or DNA that codes for ncRNA. ... -
How to Prepare for an Industry Interview
TypeBlog PostPublishedJuly 9, 2020, 1:15 p.m....ago. I just recently started working in the pharmaceuticals industry after earning my Master’s in 2016 ... -
Popular Retroviral Vectors and Their Uses in Scientific Research
TypeBlog PostPublishedJuly 24, 2018, 12:51 p.m....can express siRNAs to direct the cellular RNAi machinery to silence target genes. This empty MuLV vector... -
Educational Planarian Tools for Teaching Developmental Biology Techniques
TypeBlog PostPublishedMay 24, 2018, 1:20 p.m.... through physical blocking of the translation machinery. In the Sánchez lab protocol, dsRNAs are delivered... -
Split-BioID: An Improved Method for Studying Protein-Protein Interactions
TypeBlog PostPublishedMay 1, 2018, 1:57 p.m....PMCID: 3308701. Find the BioID Plasmids Here! Macneill, S., & Varnaitė, R. (2016). Meet the neighbors... -
CRISPR in the Clinic
TypeBlog PostPublishedNov. 2, 2023, 1:15 p.m....for these diseases was sponsored by Vertex Pharmaceuticals and CRISPR Therapeutics. Data shared from these... -
A Look Back at One Year of Plasmid Sharing for COVID-19 Research
TypeBlog PostPublishedJuly 12, 2021, 1:15 p.m....Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt ... -
Tips for Technical Support Calls
TypeBlog PostPublishedSept. 20, 2016, 2:39 p.m.... delicate balance of knowledge, patience, and diplomacy, and that balancing act is made much easier if... -
Adapting Toehold Switches to Detect Zika Virus
TypeBlog PostPublishedAug. 30, 2016, 2:30 p.m....Assistant professor in the Leslie Dan Faculty of Pharmacy at the University of Toronto. His research is ... -
Plasmids 101: Terminators and PolyA signals
TypeBlog PostPublishedMarch 31, 2016, 2:30 p.m.... newly synthesized RNA from the transcription machinery. Terminators are found downstream of the gene ... -
Reaching out to China: Canton Nucleic Acids Forum (CNAF) 2015
TypeBlog PostPublishedDec. 1, 2015, 3:30 p.m....replication of RNA in the absence of evolved enzymatic machinery (i.e. RNA replication with no proteins). The chemistry... -
The Materials Science of Optogenetics Experiments
TypeBlog PostPublishedSept. 17, 2015, 2:30 p.m....Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. Cell 162.3 (2015): 662-674...