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  1. Deciphering the Mysteries of Behavior with Viral Vectors

    Type
    Blog Post
    Published
    Sept. 17, 2019, 12:40 p.m.
    ...to the reward circuit, and the medial prefrontal cortex (mPFC) are involved. Neurons from the mPFC project... BDNF levels within the hippocampus and frontal cortex during depression, yet there have also been contradictory...involved in depression is the medial prefrontal cortex (mPFC). In 2019, the Duman lab investigated this... "Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.".... "Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant... Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction. Front Cell Neurosci. ...

  2. Important Considerations When Using AAVs

    Type
    Blog Post
    Published
    June 13, 2017, 2:30 p.m.
    ...striatum, hippocampus and cortex) within the mouse brain (4). An example from the cortex is outlined in the ...Hippocampus AAV9>AAV5>AAV8>AAV1>AAV6>AAV2 Auditory Cortex AAV9>AAV8>AAV6>AAV5>AAV1>AAV2 This preferential...the table below. Cell Type Cortex Optimal Serotype Oligodendrocytes AAV8 > AAV2 & AAV6 Microglia ...

  3. Using AAV for Neuronal Tracing

    Type
    Blog Post
    Published
    Aug. 9, 2018, 1:04 p.m.
    ...communication between the hippocampus and the prefrontal cortex brain regions is involved in the formation of episodic...neurons projects axons directly to the prefrontal cortex, but also indirectly via synapses to neurons in...transfer of herpes virus from peripheral nerves to cortex and brainstem. Science 243, 89–91. PubMed PMID:...8 and 9 in marmoset, mouse and macaque cerebral cortex, Neurosci Res 93, 144-157. PubMed PMID: 25240284...

  4. Light Sheet Fluorescence Microscopy

    Type
    Blog Post
    Published
    July 16, 2015, 2:30 p.m.
    ... Cuneate tract, dCST= dorsal cortico spinal tract, vCST= ventral cortico spinal tract, dc= decussation... first segments of the spinal cord showing the cortico spinal tract, CST, spinal cord and cranial nerve...

  5. Viral Vectors 101: AAV Variables That Matter

    Type
    Blog Post
    Published
    June 1, 2023, 1:15 p.m.
    ...adeno-associated viral vector-mediated transduction of the corticospinal tract: Comparison of four promoters. Gene Therapy...8 and 9 in marmoset, mouse and macaque cerebral cortex. Neuroscience Research, 93, 144–157. https://doi.org...Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense ...

  6. Hot Plasmids - October 2022

    Type
    Blog Post
    Published
    Oct. 6, 2022, 1:15 p.m.
    ...optogenetic silencer in experiments with mouse cortical neurons, far out-performing previous attempts ...selective for K+ over other Na+ and other cations. B) Cortical slice of HcKCR1-EYFP and tdTomato expressed layer...

  7. Addgene's Top 10 Blog Posts of 2015

    Type
    Blog Post
    Published
    Dec. 7, 2015, 6 p.m.
    ...CRISPR 101: Homology Directed Repair Addgenie Chari Cortez explains some of the basic science behind homology...your next experiment? In this post, Addgenie Chari Cortez guides us through some common controls and why ...

  9. Viral Vectors 101: Systemic Capsids

    Type
    Blog Post
    Published
    Oct. 12, 2023, 1:15 p.m.
    ...brain, but at low doses a regional bias towards the cortex and thalamus emerges. AAV-PHP.eC effectively transduces....2022.07.010 Graybuck, L. T., Daigle, T. L., Sedeño-Cortés, A. E., Walker, M., Kalmbach, B., Lenz, G. H., ...subclass-selective expression from mouse to primate neocortex. Cell Reports, 34(13). https://doi.org/10.1016...

  10. New Viral Vectors - Spring 2025

    Type
    Blog Post
    Published
    April 29, 2025, 1:30 p.m.
    ...E6 regulatory element, which targets it to VIP cortical interneurons. Take a look to see if these new ...

  19. Working with Nuclear Receptors

    Type
    Blog Post
    Published
    July 15, 2014, 4:03 p.m.
    ...are receptors for endocrine steroids (i.e., corticosteroids, progesterone, androgens, and estrogens), fat-soluble...
Showing: 1 - 20 of 32 results