We narrowed to 34 results for: CORT
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TypeBlog PostPublishedSept. 17, 2019, 12:40 p.m....to the reward circuit, and the medial prefrontal cortex (mPFC) are involved. Neurons from the mPFC project... BDNF levels within the hippocampus and frontal cortex during depression, yet there have also been contradictory...involved in depression is the medial prefrontal cortex (mPFC). In 2019, the Duman lab investigated this... "Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.".... "Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant... Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction. Front Cell Neurosci. ...
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Hot Plasmids: Spring 2025
TypeBlog PostPublishedJune 3, 2025, 1:15 p.m....somatosensory cortex (S1) of the mouse brain following retro-orbital AAV injection at 4 weeks. Cortical layers...rapid synaptic events such as in the somatosensory cortex, while iGluSnFR4s produces larger signal-to-noise...loose-seal, cell-attached recordings in primary visual cortex (V1) layer 2/3 (L2/3). B) Fluorescence from axonal...enhancer-AAV vectors targeting specific classes of cortical and striatal interneurons (Furlanis, Dai, Leyva... -
Important Considerations When Using AAVs
TypeBlog PostPublishedJune 13, 2017, 2:30 p.m....striatum, hippocampus and cortex) within the mouse brain (4). An example from the cortex is outlined in the ...Hippocampus AAV9>AAV5>AAV8>AAV1>AAV6>AAV2 Auditory Cortex AAV9>AAV8>AAV6>AAV5>AAV1>AAV2 This preferential...the table below. Cell Type Cortex Optimal Serotype Oligodendrocytes AAV8 > AAV2 & AAV6 Microglia ... -
Using AAV for Neuronal Tracing
TypeBlog PostPublishedAug. 9, 2018, 1:04 p.m....communication between the hippocampus and the prefrontal cortex brain regions is involved in the formation of episodic...neurons projects axons directly to the prefrontal cortex, but also indirectly via synapses to neurons in...transfer of herpes virus from peripheral nerves to cortex and brainstem. Science 243, 89–91. PubMed PMID:...8 and 9 in marmoset, mouse and macaque cerebral cortex, Neurosci Res 93, 144-157. PubMed PMID: 25240284... -
Light Sheet Fluorescence Microscopy
TypeBlog PostPublishedJuly 16, 2015, 2:30 p.m.... Cuneate tract, dCST= dorsal cortico spinal tract, vCST= ventral cortico spinal tract, dc= decussation... first segments of the spinal cord showing the cortico spinal tract, CST, spinal cord and cranial nerve... -
Viral Vectors 101: AAV Variables That Matter
TypeBlog PostPublishedJune 1, 2023, 1:15 p.m....adeno-associated viral vector-mediated transduction of the corticospinal tract: Comparison of four promoters. Gene Therapy...8 and 9 in marmoset, mouse and macaque cerebral cortex. Neuroscience Research, 93, 144–157. https://doi.org...Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense ... -
Hot Plasmids - October 2022
TypeBlog PostPublishedOct. 6, 2022, 1:15 p.m....optogenetic silencer in experiments with mouse cortical neurons, far out-performing previous attempts ...selective for K+ over other Na+ and other cations. B) Cortical slice of HcKCR1-EYFP and tdTomato expressed layer... -
Addgene's Top 10 Blog Posts of 2015
TypeBlog PostPublishedDec. 7, 2015, 6 p.m....CRISPR 101: Homology Directed Repair Addgenie Chari Cortez explains some of the basic science behind homology...your next experiment? In this post, Addgenie Chari Cortez guides us through some common controls and why ... -
Announcing the Winners of the 2021 Michael Davidson and Roger Tsien Commemorative Conference Awards
TypeBlog PostPublishedAug. 5, 2021, 12:15 p.m....indicator coming from the screen to understand mouse cortical and hippocampal neural microcircuits. “In the ...Citrine-tagged voltage indicator expressed in mouse cortex. Image from He Tian. Congrats again to all... -
Viral Vectors 101: Systemic Capsids
TypeBlog PostPublishedOct. 12, 2023, 1:15 p.m....brain, but at low doses a regional bias towards the cortex and thalamus emerges. AAV-PHP.eC effectively transduces....2022.07.010 Graybuck, L. T., Daigle, T. L., Sedeño-Cortés, A. E., Walker, M., Kalmbach, B., Lenz, G. H., ...subclass-selective expression from mouse to primate neocortex. Cell Reports, 34(13). https://doi.org/10.1016... -
New Viral Vectors - Spring 2025
TypeBlog PostPublishedApril 29, 2025, 1:30 p.m....E6 regulatory element, which targets it to VIP cortical interneurons. Take a look to see if these new ... -
Cre-ating New Methods for Site-specific Recombination in Drosophila
TypeBlog PostPublishedMay 12, 2015, 1:32 p.m....Chinese hamster ovary (CHO) cells, as well as in cortical neurons in layer 2/3 of the mouse brain. Rubin... -
Addgene-Seeding Labs plasmid grant round 3: microbial drug resistance and biofilms, antidiabetic plant components, visualizing brain injury - and a glowing robot fish
TypeBlog PostPublishedNov. 27, 2018, 2 p.m....scanning microscope will allow Tsakanova to image cortical neurons and study changes in neural activity after... -
The Importance of High Titer for AAV Transductions
TypeBlog PostPublishedMarch 1, 2018, 2:11 p.m....anterograde transsynaptic tagging: mapping corticocollicular input-defined neural pathways for defense ... -
Cas13d: Small RNA-targeting CRISPR enzymes for transcriptome engineering
TypeBlog PostPublishedMay 3, 2018, 1:48 p.m....enhancers. After AAV-mediated delivery to iPS-derived cortical neurons, dCasRx-mediated exon skipping improved... -
OCaMP: A New Calcium Indicator for Neural Imaging
TypeBlog PostPublishedAug. 19, 2025, 1:15 p.m....recordings (lower trace) using OCaMP expressed in mouse cortex. Bottom: Zoomed-in view of traces corresponding... -
Viral Vectors 101: The AAV Retrograde Serotype
TypeBlog PostPublishedApril 27, 2023, 1:15 p.m.... pigs (work you can find in AAV Data Hub!) The cortical pathways to the IC were well transduced by AAVrg... -
Channelrhodopsins with improved light sensitivity for minimally-invasive optogenetics
TypeBlog PostPublishedNov. 3, 2020, 2:15 p.m....methods to the neurons in the right secondary motor cortex (M2). Since M2 is located on the surface of the... -
Supporting Rare Disease Research with the 2020 BeHEARD Awards
TypeBlog PostPublishedSept. 8, 2020, 2 p.m....genetically-encoded biosensors and iPSC-derived cortical neurons from patients with GNB1 mutations, the... -
Teaching an Old DOG New Tricks: Controlling Protein Activity with GFP
TypeBlog PostPublishedNov. 24, 2015, 3:30 p.m....throughout the nervous system, including the motor cortex, cerebellum, and spinal cord. Cre-DOG is also suitable...