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  1. Allen Institute for Brain Science AAV Enhancer Collection

    Type
    Collection
    ...Rimorin C, Rocha D, Ruiz A, Sanchez REA, Sedeno-Cortes A, Sevigny JP, Shapovalova N, Shulga L, Sigler ...populations in the following regions: Isocortex Hippocampal formation Cortical subplate Striatum Pallidum Hypothalamus...CT Isocortex 230801 pAAV-AiE2575m-minBG-iCre(R297T)-BGHpA AiP20139 AiE2575m Cre Layer 6_CT Isocortex 214601... 6b Isocortex 220729 pAAV-AiE2586m-minBG-iCre(R297T)-BGHpA AiP2136 AiE2586m Cre Layer 6b Isocortex 230554... 6b Isocortex 220728 pAAV-AiE2587m-minBG-iCre(R297T)-BGHpA AiP2068 AiE2587m Cre Layer 6b Isocortex 163505...WPRE3-BGHpA AiP2105 AiE2638m SYFP2 Layer 2-3_IT Isocortex 230803 pAAV-AiE2638m-minBG-iCre(R297T)-BGHpA AiP20142... AiP20142 AiE2638m Cre Layer 2-3_IT Isocortex 214583 pAAV-AiE2543m-minBG-SYFP2-WPRE3-BGHpA AiP1924 AiE2543m...

  2. Deciphering the Mysteries of Behavior with Viral Vectors

    Type
    Blog Post
    ...to the reward circuit, and the medial prefrontal cortex (mPFC) are involved. Neurons from the mPFC project... BDNF levels within the hippocampus and frontal cortex during depression, yet there have also been contradictory...involved in depression is the medial prefrontal cortex (mPFC). In 2019, the Duman lab investigated this... "Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.".... "Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant... Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction. Front Cell Neurosci. ...

  3. Important Considerations When Using AAVs

    Type
    Blog Post
    ...striatum, hippocampus and cortex) within the mouse brain (4). An example from the cortex is outlined in the ...Hippocampus AAV9>AAV5>AAV8>AAV1>AAV6>AAV2 Auditory Cortex AAV9>AAV8>AAV6>AAV5>AAV1>AAV2 This preferential...the table below. Cell Type Cortex Optimal Serotype Oligodendrocytes AAV8 > AAV2 & AAV6 Microglia ...

  4. Using AAV for Neuronal Tracing

    Type
    Blog Post
    ...communication between the hippocampus and the prefrontal cortex brain regions is involved in the formation of episodic...neurons projects axons directly to the prefrontal cortex, but also indirectly via synapses to neurons in...transfer of herpes virus from peripheral nerves to cortex and brainstem. Science 243, 89–91. PubMed PMID:...8 and 9 in marmoset, mouse and macaque cerebral cortex, Neurosci Res 93, 144-157. PubMed PMID: 25240284...

  5. Light Sheet Fluorescence Microscopy

    Type
    Blog Post
    ... Cuneate tract, dCST= dorsal cortico spinal tract, vCST= ventral cortico spinal tract, dc= decussation... first segments of the spinal cord showing the cortico spinal tract, CST, spinal cord and cranial nerve...

  6. Viral Vectors 101: AAV Variables That Matter

    Type
    Blog Post
    ...adeno-associated viral vector-mediated transduction of the corticospinal tract: Comparison of four promoters. Gene Therapy...8 and 9 in marmoset, mouse and macaque cerebral cortex. Neuroscience Research, 93, 144–157. https://doi.org...Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense ...

  7. Hot Plasmids - October 2022

    Type
    Blog Post
    ...optogenetic silencer in experiments with mouse cortical neurons, far out-performing previous attempts ...selective for K+ over other Na+ and other cations. B) Cortical slice of HcKCR1-EYFP and tdTomato expressed layer...

  8. Addgene's Top 10 Blog Posts of 2015

    Type
    Blog Post
    ...CRISPR 101: Homology Directed Repair Addgenie Chari Cortez explains some of the basic science behind homology...your next experiment? In this post, Addgenie Chari Cortez guides us through some common controls and why ...

  10. Viral Vectors 101: Systemic Capsids

    Type
    Blog Post
    ...brain, but at low doses a regional bias towards the cortex and thalamus emerges. AAV-PHP.eC effectively transduces....2022.07.010 Graybuck, L. T., Daigle, T. L., Sedeño-Cortés, A. E., Walker, M., Kalmbach, B., Lenz, G. H., ...subclass-selective expression from mouse to primate neocortex. Cell Reports, 34(13). https://doi.org/10.1016...

  11. New Viral Vectors - Spring 2025

    Type
    Blog Post
    ...E6 regulatory element, which targets it to VIP cortical interneurons. Take a look to see if these new ...

  20. Working with Nuclear Receptors

    Type
    Blog Post
    ...are receptors for endocrine steroids (i.e., corticosteroids, progesterone, androgens, and estrogens), fat-soluble...
Showing: 1 - 20 of 46 results