...neurons (Drd1) in mPFC is responsible for the antidepressant effect. To specifically activate the Drd1 neurons...neurons, they injected AAV2 particles into a Drd1-Cre transgenic mouse to deliver Cre-dependent expression... upon light stimulation. When they activated the Drd1 neurons 24 hours before the forced swim test, they...Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant...